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公开(公告)号:US20090054460A1
公开(公告)日:2009-02-26
申请号:US12008696
申请日:2008-01-11
申请人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号: A61K31/495 , C07D241/04
CPC分类号: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07393852B2
公开(公告)日:2008-07-01
申请号:US10874086
申请日:2004-06-21
申请人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人: Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号: A61K31/54 , A61K31/4965 , C07D241/04 , C07D265/30 , C07D279/12
CPC分类号: C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20090048224A1
公开(公告)日:2009-02-19
申请号:US12205616
申请日:2008-09-05
申请人: Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
发明人: Robert D. Groneberg , Benny C. Askew, JR. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC分类号: A61K31/397 , A61K31/453 , C07D401/02 , C07D405/02 , A61K31/496 , A61K31/4545 , C07D407/02 , A61K31/4025 , A61K31/351 , A61P27/02 , A61P27/06 , A61P11/06 , A61P9/00 , A61P19/02 , A61P25/28 , A61K31/4375 , C07D471/04 , C07D205/04 , A61P3/10 , C07D311/02 , C07D413/02 , A61K31/5377 , A61K31/5415 , C07D279/02 , C07C311/01 , A61K31/18
CPC分类号: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07425631B2
公开(公告)日:2008-09-16
申请号:US10823377
申请日:2004-04-12
申请人: Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
发明人: Robert D. Groneberg , Benny C. Askew, Jr. , Derin C. D'Amico , James Zhan , Andras Toro , Youngboo Kim , David A. Mareska , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Kevin Yang , Aiwen Li , Chester Chenguang Yuan , Kaustav Biswas , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jian Jeffrey Chen , Rana Nomak
IPC分类号: C07D215/04
CPC分类号: C07C311/19 , C07C311/13 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/20 , C07D209/14 , C07D209/16 , C07D209/40 , C07D209/52 , C07D211/38 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/70 , C07D213/42 , C07D213/56 , C07D213/64 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/22 , C07D233/54 , C07D239/74 , C07D271/08 , C07D277/64 , C07D279/02 , C07D285/14 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/14 , C07D307/28 , C07D307/79 , C07D307/81 , C07D311/68 , C07D317/58 , C07D333/20 , C07D333/24 , C07D333/58 , C07D333/62 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/08
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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5.
公开(公告)号:US07662811B2
公开(公告)日:2010-02-16
申请号:US11182216
申请日:2005-07-15
申请人: Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
发明人: Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
IPC分类号: A01N43/00 , A61K31/00 , A61K31/55 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C07D221/10 , C07D221/08 , C07D239/74 , C07D241/08 , C07D243/08 , C07D249/08 , C07D295/135 , C07D311/96 , C07D335/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D491/04
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07199244B2
公开(公告)日:2007-04-03
申请号:US10823372
申请日:2004-04-12
申请人: Robert D. Groneberg , James Zhan , Benny C. Askew, Jr. , Derin C. D'Amico , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Jiawang Zhu , Kevin Yang , Jian Jeffrey Chen , Rana Nomak
发明人: Robert D. Groneberg , James Zhan , Benny C. Askew, Jr. , Derin C. D'Amico , Nianhe Han , Christopher H. Fotsch , Qingyian Liu , Babak Riahi , Jiawang Zhu , Kevin Yang , Jian Jeffrey Chen , Rana Nomak
IPC分类号: C07D211/08 , C07D405/00
CPC分类号: C07D207/48 , C07D211/96 , C07D215/58 , C07D217/22 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。 本发明包括新的化合物,类似物,前药和其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及疼痛,炎症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07414134B2
公开(公告)日:2008-08-19
申请号:US11247050
申请日:2005-10-11
IPC分类号: C07D211/04 , C07D261/08 , C07D249/04 , C07D249/06
CPC分类号: C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译: 本发明包括新颖的化合物及其药学上可接受的衍生物,用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号:US20080249106A1
公开(公告)日:2008-10-09
申请号:US12082076
申请日:2008-04-08
申请人: Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
发明人: Benny C. Askew , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
IPC分类号: A61K31/496 , C07D249/06 , A61K31/4192 , A61K31/454 , C07D401/08 , C07D403/08
CPC分类号: C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要: The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译: 本发明包括新颖的化合物及其药学上可接受的衍生物,用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。
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公开(公告)号:US20110118252A1
公开(公告)日:2011-05-19
申请号:US12945575
申请日:2010-11-12
申请人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号: A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC分类号: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20080312232A1
公开(公告)日:2008-12-18
申请号:US11412302
申请日:2006-04-26
申请人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号: A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC分类号: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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