利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

310 条记录 (耗时 0.034 秒)

    Polynucleotides encoding a human chemotactic cytokine I
    3.
    发明授权
    Polynucleotides encoding a human chemotactic cytokine I 失效
    编码人趋化因子I的多核苷酸

    公开(公告)号：US07393943B1

    公开(公告)日：2008-07-01

    申请号：US08761289

    申请日：1996-12-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Polynucleotides encoding human G-protein coupled receptor GPRZ
    4.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor GPRZ 失效
    编码人G蛋白偶联受体GPR2的多核苷酸

    公开(公告)号：US5998164A

    公开(公告)日：1999-12-07

    申请号：US467948

    申请日：1995-06-06

    申请人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/715 ,  C12N15/12 ,  C12N15/62

    CPC分类号： C07K14/7158 ,  C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体或多肽和编码此类多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    DNA encoding human cystatin E
    5.
    发明授权
    DNA encoding human cystatin E 失效
    编码人半胱氨酸蛋白酶抑制剂E的DNA

    公开(公告)号：US5985601A

    公开(公告)日：1999-11-16

    申请号：US461030

    申请日：1995-06-05

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/81 ,  C12N15/12 ,  C12N15/19 ,  C07K14/52 ,  C12N15/63

    CPC分类号： C07K14/8139 ,  A61K38/00

    摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachexia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，恶病质和肌肉消瘦的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Cytostatin I
    6.
    发明授权
    Cytostatin I 失效
    细胞抑素I

    公开(公告)号：US5977309A

    公开(公告)日：1999-11-02

    申请号：US23073

    申请日：1998-02-13

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A human cytostatin I polypeptide an DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.

    摘要翻译： 公开了人细胞培养抑制因子I多肽编码这种多肽的DNA和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。

    Cytostatin I
    7.
    发明授权
    Cytostatin I 失效
    细胞抑素I

    公开(公告)号：US5844081A

    公开(公告)日：1998-12-01

    申请号：US470298

    申请日：1995-06-06

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other metastases.

    摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其他转移的方法。

    Polynucleotides encoding natural killer cell enhancing factor C
    8.
    发明授权
    Polynucleotides encoding natural killer cell enhancing factor C 失效

    公开(公告)号：US5985612A

    公开(公告)日：1999-11-16

    申请号：US467265

    申请日：1995-06-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    Nucleic acid molecules encoding cytostatin I
    9.
    发明授权
    Nucleic acid molecules encoding cytostatin I 失效
    编码细胞抑素I的核酸分子

    公开(公告)号：US06287812B1

    公开(公告)日：2001-09-11

    申请号：US09361737

    申请日：1999-07-28

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： C12N1512

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.

    摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。

    Polynucleotides encoding natural killer cell enhancing factor C
    10.
    发明授权
    Polynucleotides encoding natural killer cell enhancing factor C 失效
    编码天然杀伤细胞增强因子C的多核苷酸

    公开(公告)号：US06255079B1

    公开(公告)日：2001-07-03

    申请号：US08467265

    申请日：1995-06-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    IPC分类号： C07K1452

    CPC分类号： C07K14/52 ,  A61K38/00 ,  Y10S514/885

    摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。