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公开(公告)号：US10365213B2
公开(公告)日：2019-07-30
申请号：US12997223
申请日：2008-06-11
申请人： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
发明人： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
摘要： Methods and devices use in two-color measurement systems. The methods and devices include methods of making corrections, methods of calculating correction factors, fluorescence scanners, and microarray chips. The said methods and devices enable a user to correct fluorescence intensities for errors caused by the occurrence of FRET and/or cross-talk when two fluorophores are used in two-color fluorescence arrays.
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2.发明申请RELIABLE FLUORESCENCE CORRECTION METHOD FOR TWO-COLOR MEASUREMENT FLUORESCENCE SYSTEM 审中-公开用于两色度测量荧光系统的可靠荧光校正方法公开(公告)号：US20110301062A1
公开(公告)日：2011-12-08
申请号：US12997223
申请日：2008-06-11
申请人： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
发明人： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
CPC分类号： G01N21/278 , G01N21/6452 , G01N2021/6421 , G01N2021/6441
摘要： Methods and devices use in two-color measurement systems. The methods and devices include methods of making corrections, methods of calculating correction factors, fluorescence scanners, and microarray chips. The said methods and devices enable a user to correct fluorescence intensities for errors caused by the occurrence of FRET and /or cross-talk when two fluorophores are used in two-color fluorescence arrays.
摘要翻译： 方法和设备用于双色测量系统。 方法和装置包括进行校正的方法，计算校正因子的方法，荧光扫描仪和微阵列芯片。 所述方法和装置使得用户能够在双色荧光阵列中使用两个荧光团时，校正由FRET和/或串扰的发生引起的误差的荧光强度。
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公开(公告)号：US20080252954A1
公开(公告)日：2008-10-16
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： G02B26/08
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译： 本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。 在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。 本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描
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公开(公告)号：US09445840B2
公开(公告)日：2016-09-20
申请号：US13805322
申请日：2011-06-17
申请人： Chao Han , Guoliang Huang , Jing Cheng
发明人： Chao Han , Guoliang Huang , Jing Cheng
CPC分类号： A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
摘要： An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
摘要翻译： 提供集成的微流体装置及其用途。 微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。 上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。 微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。 集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。
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公开(公告)号：US07615758B2
公开(公告)日：2009-11-10
申请号：US11795660
申请日：2005-06-02
申请人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC分类号： F21V9/16
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译： 本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。 在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。 本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描
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公开(公告)号：US20090101805A1
公开(公告)日：2009-04-23
申请号：US11795652
申请日：2005-06-02
申请人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
IPC分类号： H01J40/14
CPC分类号： G01N35/04 , G01N35/028
摘要： The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
摘要翻译： 本发明提供了用于微阵列高速扫描的扫描平台。 该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。 本发明的平台提供高移动速度，高分辨率和低返回偏差。 结构简单，制造成本低。
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公开(公告)号：US07706419B2
公开(公告)日：2010-04-27
申请号：US11795653
申请日：2005-06-03
申请人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
发明人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
IPC分类号： H01S3/10
CPC分类号： G02B21/002 , G01N21/6452
摘要： The invention provides a novel optical system for use in a microarray scanner, comprising an aperture-containing reflecting mirror comprising an aperture and a reflecting surface. The aperture of the aperture-containing reflecting mirror allows an excitation light to pass through, and the reflecting surface of the aperture-containing reflecting mirror allows emission light from a microarray to be reflected. The optical system may also comprises various other components such as laser generators, beam splitter, reflecting mirrors, excitation and emission light filters, excitation and emission objective lens, pinhole, and detector. The optical system described herein has high efficiency, high sensitivity, low background noise, structurally simple, and high versatility.
摘要翻译： 本发明提供了一种用于微阵列扫描仪的新型光学系统，其包括一个包含孔和反射表面的孔径反射镜。 含孔反射镜的孔径允许激发光通过，并且含孔反射镜的反射表面允许来自微阵列的发射光被反射。 光学系统还可以包括诸如激光发生器，分束器，反射镜，激发和发射滤光器，激发和发射物镜，针孔和检测器的各种其它部件。 本文描述的光学系统具有高效率，高灵敏度，低背景噪声，结构简单和高通用性。
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公开(公告)号：US20090046756A1
公开(公告)日：2009-02-19
申请号：US11795653
申请日：2005-06-03
申请人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
发明人： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
CPC分类号： G02B21/002 , G01N21/6452
摘要： The invention provides a novel optical system for use in a microarray scanner, comprising an aperture-containing reflecting mirror comprising an aperture and a reflecting surface. The aperture of the aperture-containing reflecting mirror allows an excitation light to pass through, and the reflecting surface of the aperture-containing reflecting mirror allows emission light from a microarray to be reflected. The optical system may also comprises various other components such as laser generators, beam splitter, reflecting mirrors, excitation and emission light filters, excitation and emission objective lens, pinhole, and detector. The optical system described herein has high efficiency, high sensitivity, low background noise, structurally simple, and high versatility.
摘要翻译： 本发明提供了一种用于微阵列扫描仪的新型光学系统，其包括一个包含孔和反射表面的孔径反射镜。 含孔反射镜的孔径允许激发光通过，并且含孔反射镜的反射表面允许来自微阵列的发射光被反射。 光学系统还可以包括诸如激光发生器，分束器，反射镜，激发和发射滤光器，激发和发射物镜，针孔和检测器的各种其它部件。 本文描述的光学系统具有高效率，高灵敏度，低背景噪声，结构简单和高通用性。
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公开(公告)号：US20130204076A1
公开(公告)日：2013-08-08
申请号：US13805322
申请日：2011-06-17
申请人： Chao Han , Guoliang Huang , Jing Cheng
发明人： Chao Han , Guoliang Huang , Jing Cheng
IPC分类号： A61B17/43
CPC分类号： A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
摘要： An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
摘要翻译： 提供集成的微流体装置及其用途。 微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。 上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。 微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。 集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。
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公开(公告)号：US07928357B2
公开(公告)日：2011-04-19
申请号：US11795652
申请日：2005-06-02
申请人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
发明人： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
CPC分类号： G01N35/04 , G01N35/028
摘要： The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
摘要翻译： 本发明提供了用于微阵列高速扫描的扫描平台。 该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。 本发明的平台提供高移动速度，高分辨率和低返回偏差。 结构简单，制造成本低。
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