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公开(公告)号：US20220412422A1
公开(公告)日：2022-12-29
申请号：US17679854
申请日：2022-02-24
Applicant: Guoliang Huang , Hussein Nassar , Yangyang Chen , Xianchen Xu
Inventor： Guoliang Huang , Hussein Nassar , Yangyang Chen , Xianchen Xu
Abstract: An elastic wave cloaking lattice-based metamaterial for cloaking an object within a void includes a lattice of connected unit cells arranged to form a void, each unit cell comprising a mass and a plurality of connecting springs, the mass coupled by the plurality of connecting springs to masses in adjacent unit cells, the plurality of connecting springs comprising at least two large springs of a first length and at least two short springs of a second length, the first length greater than the second length, the springs and masses having relational and mechanical characteristics to facilitate elastic wave cloaking in the totality of the lattice. The lattice as a whole has metamaterial properties resulting from the positional relationship and mechanical properties of masses and connecting springs of the unit cells such that the lattice at least partially cloaks an object or material portioned within the void from elastic waves.
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公开(公告)号：US09445840B2
公开(公告)日：2016-09-20
申请号：US13805322
申请日：2011-06-17
Applicant: Chao Han , Guoliang Huang , Jing Cheng
Inventor： Chao Han , Guoliang Huang , Jing Cheng
CPC classification number: A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
Abstract: An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
Abstract translation: 提供集成的微流体装置及其用途。 微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。 上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。 微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。 集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。
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公开(公告)号：US07615758B2
公开(公告)日：2009-11-10
申请号：US11795660
申请日：2005-06-02
Applicant: Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
Inventor： Xianhua Wang , Hui Xu , Jianxin Ye , Yelei Sun , Guoliang Huang , Jing Cheng
IPC: F21V9/16
CPC classification number: G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
Abstract: The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
Abstract translation: 本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。 在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。 本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描
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公开(公告)号：US20090101805A1
公开(公告)日：2009-04-23
申请号：US11795652
申请日：2005-06-02
Applicant: Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
Inventor： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
IPC: H01J40/14
CPC classification number: G01N35/04 , G01N35/028
Abstract: The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
Abstract translation: 本发明提供了用于微阵列高速扫描的扫描平台。 该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。 本发明的平台提供高移动速度，高分辨率和低返回偏差。 结构简单，制造成本低。
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公开(公告)号：US20130204076A1
公开(公告)日：2013-08-08
申请号：US13805322
申请日：2011-06-17
Applicant: Chao Han , Guoliang Huang , Jing Cheng
Inventor： Chao Han , Guoliang Huang , Jing Cheng
IPC: A61B17/43
CPC classification number: A61B17/43 , A61B17/435 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2300/0851 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M47/04
Abstract: An integrated microfluidic device and its usage are provided. The microfluidic device comprises an upper layer (1) and a lower layer (2), wherein the lower layer (2) is bound to the upper layer (1). The upper layer (1) comprises a micro-channel (3) and the lower layer (2) comprises a micro-well (7) array. The micro-channel (3) is in fluidic connection with the micro-well (7) array, and the height of the micro-channel (3) is greater than the diameter of the oocyte (4) flowing through the micro-channel (3). The integrated microfluidic device has many advantages including low cost, high integration, and convenient operation, and has application prospects in reproductive medicine and the research of fertilization and embryo early development.
Abstract translation: 提供集成的微流体装置及其用途。 微流体装置包括上层（1）和下层（2），其中下层（2）与上层（1）结合。 上层（1）包括微通道（3），下层（2）包括微孔（7）阵列。 微通道（3）与微孔（7）阵列流体连接，并且微通道（3）的高度大于流过微通道的卵母细胞（4）的直径（ 3）。 集成微流体装置具有成本低，整合性高，操作方便等优点，在生殖医学和受精胚胎早期发育研究中具有应用前景。
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Patent Agency Ranking
公开(公告)号：US07928357B2
公开(公告)日：2011-04-19
申请号：US11795652
申请日：2005-06-02
Applicant: Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
Inventor： Xianhua Wang , Hui Zhu , Guoliang Huang , Jing Cheng
CPC classification number: G01N35/04 , G01N35/028
Abstract: The invention provides a scanning platform for high speed scanning of microarrays. The platform uses a novel flexible a metal strip/wheel linear driving system to convert rotary movement of motors into linear movement, thereby drives movement of a stage/microarray in the direction of scanning. The platform of the present invention provides high movement speed, high resolution, and low return deviation. It is also simple in structure and low in manufacturing cost.
Abstract translation: 本发明提供了用于微阵列高速扫描的扫描平台。 该平台使用新颖的柔性金属条/轮线性驱动系统将马达的旋转运动转换为直线运动，从而驱动载物台/微阵列沿扫描方向的移动。 本发明的平台提供高移动速度，高分辨率和低返回偏差。 结构简单，制造成本低。
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7.发明申请Dynamic Sampling System and Method for In Vivo Fluorescent Molecular Imaging 审中-公开动态采样系统和体内荧光分子成像方法公开(公告)号：US20090018451A1
公开(公告)日：2009-01-15
申请号：US12053355
申请日：2008-03-21
Applicant: Jing Bai , Xiaolei Song , Gang Hu , Junjie Yao , Zhun Xu , Daifa Wang , Jianchang Ou , Guoliang Huang , Yonghong Zhang
Inventor： Jing Bai , Xiaolei Song , Gang Hu , Junjie Yao , Zhun Xu , Daifa Wang , Jianchang Ou , Guoliang Huang , Yonghong Zhang
IPC: A61B5/00
CPC classification number: G01N21/6456 , A61B5/0073 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B2503/40 , G01N21/6428 , G01N2021/1787
Abstract: A dynamic dada sampling system and method is disclosed for in vivo small animal fluorescence molecular imaging and dual-modality molecular imaging. The system comprises a computer, a rotation stage for animal suspension driven by a motor, and a fluorescence excitation-detection apparatus. The fluorescence excitation-detection apparatus comprises a fluorescence excitation module and a fluorescence detection module. The CCD device of the fluorescence detection module is connected to a computer through an interface controller. The motor is connected to a computer through RS232 interface. The process of dynamic data acquisition is as follows: a fluorescent probe is injected into a small animal in order to target specific cells or tissues; a small animal is vertically hung on a rotation stage after anesthesia; the fluorescence imaging detection module acquires the emitting light continuously. The present invention can provide 360 degree imaging quickly, efficiently, and non-invasively.
Abstract translation: 公开了用于体内小动物荧光分子成像和双重模态分子成像的动态dada采样系统和方法。 该系统包括计算机，由电动机驱动的用于动物悬架的旋转台和荧光激发检测装置。 荧光激发检测装置包括荧光激发模块和荧光检测模块。 荧光检测模块的CCD器件通过接口控制器连接到计算机。 电机通过RS232接口连接到电脑。 动态数据采集过程如下：将荧光探针注射到小动物中以靶向特定细胞或组织; 麻醉后，一只小动物垂直悬挂在旋转台上; 荧光成像检测模块连续获取发光。 本发明可以快速，有效和非侵入地提供360度成像。
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公开(公告)号：US10365213B2
公开(公告)日：2019-07-30
申请号：US12997223
申请日：2008-06-11
Applicant: Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
Inventor： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
Abstract: Methods and devices use in two-color measurement systems. The methods and devices include methods of making corrections, methods of calculating correction factors, fluorescence scanners, and microarray chips. The said methods and devices enable a user to correct fluorescence intensities for errors caused by the occurrence of FRET and/or cross-talk when two fluorophores are used in two-color fluorescence arrays.
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9.发明申请RELIABLE FLUORESCENCE CORRECTION METHOD FOR TWO-COLOR MEASUREMENT FLUORESCENCE SYSTEM 审中-公开用于两色度测量荧光系统的可靠荧光校正方法公开(公告)号：US20110301062A1
公开(公告)日：2011-12-08
申请号：US12997223
申请日：2008-06-11
Applicant: Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
Inventor： Jiang Zhu , Cheng Deng , Guoliang Huang , Shukuan Xu , Jing Cheng
CPC classification number: G01N21/278 , G01N21/6452 , G01N2021/6421 , G01N2021/6441
Abstract: Methods and devices use in two-color measurement systems. The methods and devices include methods of making corrections, methods of calculating correction factors, fluorescence scanners, and microarray chips. The said methods and devices enable a user to correct fluorescence intensities for errors caused by the occurrence of FRET and /or cross-talk when two fluorophores are used in two-color fluorescence arrays.
Abstract translation: 方法和设备用于双色测量系统。 方法和装置包括进行校正的方法，计算校正因子的方法，荧光扫描仪和微阵列芯片。 所述方法和装置使得用户能够在双色荧光阵列中使用两个荧光团时，校正由FRET和/或串扰的发生引起的误差的荧光强度。
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公开(公告)号：US07706419B2
公开(公告)日：2010-04-27
申请号：US11795653
申请日：2005-06-03
Applicant: Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
Inventor： Xianhua Wang , Guoliang Huang , Jing Cheng , Hong Zhang , Taishan Gao
IPC: H01S3/10
CPC classification number: G02B21/002 , G01N21/6452
Abstract: The invention provides a novel optical system for use in a microarray scanner, comprising an aperture-containing reflecting mirror comprising an aperture and a reflecting surface. The aperture of the aperture-containing reflecting mirror allows an excitation light to pass through, and the reflecting surface of the aperture-containing reflecting mirror allows emission light from a microarray to be reflected. The optical system may also comprises various other components such as laser generators, beam splitter, reflecting mirrors, excitation and emission light filters, excitation and emission objective lens, pinhole, and detector. The optical system described herein has high efficiency, high sensitivity, low background noise, structurally simple, and high versatility.
Abstract translation: 本发明提供了一种用于微阵列扫描仪的新型光学系统，其包括一个包含孔和反射表面的孔径反射镜。 含孔反射镜的孔径允许激发光通过，并且含孔反射镜的反射表面允许来自微阵列的发射光被反射。 光学系统还可以包括诸如激光发生器，分束器，反射镜，激发和发射滤光器，激发和发射物镜，针孔和检测器的各种其它部件。 本文描述的光学系统具有高效率，高灵敏度，低背景噪声，结构简单和高通用性。
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