RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR

    公开(公告)号:US20200062847A1

    公开(公告)日:2020-02-27

    申请号:US16488667

    申请日:2017-03-04

    发明人: Ying Zhang

    IPC分类号: C07K16/28

    摘要: Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.

    Localized congestion exposure
    8.
    发明授权
    Localized congestion exposure 有权
    本地化拥堵风险

    公开(公告)号:US08982694B2

    公开(公告)日:2015-03-17

    申请号:US12976067

    申请日:2010-12-22

    摘要: A method for localized congestion exposure within a local loop in a cellular network that is performed by a localized congestion exposure receiver node of the local loop. The method includes receiving downlink packets destined for a downstream user device. The downlink packets have headers that indicate a level of congestion experienced by the downlink packets. The headers also indicate a level of expected downstream congestion declared by an upstream node. The method also includes forwarding the downlink packets to the downstream user device through a wireless connection. The method further includes sending packets upstream that have feedback indicative of the level of congestion experienced by the downlink packets and any congestion experienced within the localized congestion exposure receiver node.

    摘要翻译: 一种在本地环路的本地拥塞暴露接收器节点执行的蜂窝网络中本地环路内的局部拥塞暴露的方法。 该方法包括接收去往下游用户设备的下行链路分组。 下行链路分组具有指示下行链路分组经历的拥塞的级别的报头。 标头还指示由上游节点声明的预期下游拥塞的级别。 该方法还包括通过无线连接将下行链路分组转发到下游用户设备。 该方法还包括向上游发送具有指示下行链路分组经历的拥塞的级别以及局部拥塞暴露接收机节点内经历的任何拥塞的反馈的分组。

    Quantifying user quality of experience by passive monitoring
    9.
    发明授权
    Quantifying user quality of experience by passive monitoring 有权
    通过被动监测量化用户体验质量

    公开(公告)号:US08972568B2

    公开(公告)日:2015-03-03

    申请号:US13401645

    申请日:2012-02-21

    摘要: A method is implemented in a network element to generate quality of experience (QoE) metrics for hypertext transfer protocol (HTTP) sessions over a network between a user device and an HTTP server. The QoE metrics are based on detecting premature termination of a download process that indicate low QoE. This QoE metric data can then be utilized by network administrators or service providers to adjust network characteristics to improve the QoE or to offer changes in services to a customer that would improve the QoE.

    摘要翻译: 在网络元件中实现一种方法,以通过用户设备和HTTP服务器之间的网络生成超文本传输​​协议(HTTP)会话的体验质量(QoE)度量。 QoE指标基于检测到表示低QoE的下载过程的过早终止。 网络管理员或服务提供商可以利用此QoE度量数据来调整网络特性,以改善QoE或为改善QoE的客户提供服务变更。