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    4-thio coumarins
    1.
    发明授权
    4-thio coumarins 失效
    4-硫香豆素

    公开(公告)号：US07148253B2

    公开(公告)日：2006-12-12

    申请号：US10752654

    申请日：2004-01-06

    申请人： Jie Wu ,  Zhen Yang ,  Reza Fathi ,  Qiang Zhu

    发明人： Jie Wu ,  Zhen Yang ,  Reza Fathi ,  Qiang Zhu

    IPC分类号： A61K31/35

    CPC分类号： C07D311/56 ,  C07D311/54

    摘要： 4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by adiministering 4-thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers.

    摘要翻译： 提供4-硫代取代的香豆素衍生物，4,5-二硫代取代的香豆素衍生物和香豆素二聚体，以及其制备方法。 本发明还提供了通过加入4-硫代取代的香豆素衍生物，4,5-二硫基取代的香豆素衍生物和香豆素二聚体来治疗丙型肝炎病毒（HCV）的方法和组合物。

    4-thio coumarins
    2.
    发明授权
    4-thio coumarins 失效
    4-硫香豆素

    公开(公告)号：US06703514B2

    公开(公告)日：2004-03-09

    申请号：US10437768

    申请日：2003-05-13

    申请人： Jie Wu ,  Zhen Yang ,  Reza Fathi ,  Qiang Zhu ,  Lisha Wang

    发明人： Jie Wu ,  Zhen Yang ,  Reza Fathi ,  Qiang Zhu ,  Lisha Wang

    IPC分类号： C07D31102

    CPC分类号： C07D311/56

    摘要： 4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which maintains a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of 4-thio substituted coumarin derivatives for biological screening.

    摘要翻译： 提供4-硫代取代的香豆素衍生物和香豆素二聚体，以及它们的制备方法。 提供了用于制备4-硫代取代香豆素衍生物的合成方法，其使用温和的反应条件，其保持高的取代基耐受性，并且适用于制备用于生物筛选的4-硫代取代的香豆素衍生物文库的固相合成。

    Detection and filtering of an undesired narrowband signal contribution in a wireless signal receiver
    3.
    发明授权
    Detection and filtering of an undesired narrowband signal contribution in a wireless signal receiver 有权
    在无线信号接收机中对不期望的窄带信号贡献的检测和滤波

    公开(公告)号：US09008249B2

    公开(公告)日：2015-04-14

    申请号：US13371311

    申请日：2012-02-10

    申请人： Jie Wu ,  Emilija M. Simic ,  Timothy Paul Pals ,  Duong A. Hoang

    发明人： Jie Wu ,  Emilija M. Simic ,  Timothy Paul Pals ,  Duong A. Hoang

    IPC分类号： H04B1/10 ,  G01S19/21

    CPC分类号： G01S19/21 ,  H04B1/1036

    摘要： Techniques are provided which may be implemented using various methods and/or apparatuses in a device comprising a receiver to scan a spectral band of a received signal comprising a desired signal contribution to determine whether signal data associated with at least a sub-band of the spectral band further comprises at least one undesired signal contribution. In response to determining that the signal data comprises at least one undesired signal contribution, the mobile station may initiate at least one notch filter to affect the undesired signal contribution in subsequent signal data associated with the received signal.

    摘要翻译： 提供了技术，其可以使用包括接收机的各种方法和/或装置来实现，该接收机扫描包括期望信号贡献的接收信号的频谱带，以确定与至少频谱的子带相关联的信号数据 频带还包括至少一个不需要的信号贡献。 响应于确定信号数据包括至少一个不需要的信号贡献，移动台可以启动至少一个陷波滤波器以影响与接收信号相关联的后续信号数据中的不期望的信号贡献。

    INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER
    9.
    发明申请
    INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER 有权
    INDOLINE SCAFFOLD SHP-2抑制剂和治疗癌症的方法

    公开(公告)号：US20120034186A1

    公开(公告)日：2012-02-09

    申请号：US13274699

    申请日：2011-10-17

    申请人： Jie Wu ,  Nicholas James Lawrence ,  Said M. Sebti ,  Harshani Rithma Lawrence

    发明人： Jie Wu ,  Nicholas James Lawrence ,  Said M. Sebti ,  Harshani Rithma Lawrence

    IPC分类号： A61K38/21 ,  A61P35/00 ,  C07D209/40 ,  A61K31/404 ,  C07D403/04 ,  A61K31/497

    CPC分类号： C07D209/34 ,  C07D209/12 ,  C07D209/40 ,  C07D215/36

    摘要： Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.

    摘要翻译： 蛋白酪氨酸磷酸酶（PTP）Shp2是参与细胞信号传导和调节细胞增殖，分化和迁移的非受体PTP。 Shp2介导参与人类癌症发病机制的激酶活化。 高通量筛选鉴定抑制PTP Shp2的化合物。 鉴定出几种化合物选择性地抑制Shp2超过Shp1，具有低至亚微摩尔的活性。 还公开了抑制细胞中的蛋白质酪氨酸磷酸酶并通过选择性抑制Shp2治疗癌症的方法。