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公开(公告)号：US20050256174A1
公开(公告)日：2005-11-17
申请号：US11149332
申请日：2005-06-10
申请人： Jill Wood , Hanno Wild , Daniel Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger Smith , Cheri Blum
发明人： Jill Wood , Hanno Wild , Daniel Rogers , John Lyons , Michael Katz , Yolanda Caringal , Robert Dally , Wendy Lee , Roger Smith , Cheri Blum
IPC分类号： A61K31/38 , A61K31/381 , A61K31/416 , A61K31/433 , C07D207/34 , C07D307/68 , C07D333/38 , C07D333/42 , C07D409/00 , C07D409/12 , C07D417/12
CPC分类号： C07D207/34 , C07D307/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号：US20070244120A1
公开(公告)日：2007-10-18
申请号：US11768112
申请日：2007-06-25
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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3.发明申请2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US20050215594A1
公开(公告)日：2005-09-29
申请号：US11117759
申请日：2005-04-28
申请人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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4.发明授权Hydroxy, ω-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors 有权羟基，ω-羧基芳基取代的二苯基脲和其衍生物作为raf激酶抑制剂公开(公告)号：US07528255B2
公开(公告)日：2009-05-05
申请号：US10071248
申请日：2002-02-11
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： C07D211/72 , C07D213/62 , C07D213/78
CPC分类号： C07D295/192 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D401/12 , C07F7/1804
摘要： The invention relates to the use of a group of aryl ureas in treating raf mediated diseases and pharmaceutical compositions for use in such therapy of the formula wherein, Y is NHR Hal is chlorine or bromine, R is H, CH3 or CH2OH, and X1 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl, or a salt purified stereoisomer thereof, wherein at least one of X1 to X7 is OH or —OC(O)C1-C4 alkyl.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途以及用于下列治疗的药物组合物：其中Y是NHR Hal是氯或溴，R是H，CH3或CH2OH，X1至 X 7各自独立地为H，OH或-OC（O）C 1 -C 4烷基或其盐纯化的立体异构体，其中X 1至X 7中的至少一个为OH或-OC（O）C 1 -C 4烷基。
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5.发明申请Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinease Inhibitors 审中-公开ω-羧酰基取代的二苯基脲作为Raf Kinease抑制剂公开(公告)号：US20080032979A1
公开(公告)日：2008-02-07
申请号：US11845595
申请日：2007-08-27
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , Scott William , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reink Natero , Joel Renick , Robert Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , Scott William , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reink Natero , Joel Renick , Robert Sibley
IPC分类号： A61K31/4035 , A61K31/17 , A61K31/44 , A61K31/5377 , A61P35/00 , C07C275/28 , C07D209/48 , C07D213/62 , C07D413/12
CPC分类号： C07C275/36 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D295/192 , C07D401/12 , C07D413/12 , C07F7/1804
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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6.发明申请公开(公告)号：US20060019990A1
公开(公告)日：2006-01-26
申请号：US11158048
申请日：2005-06-22
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D213/40
摘要： The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及含有用于这种治疗的这些尿素的药物组合物。
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7.发明申请公开(公告)号：US20080027061A1
公开(公告)日：2008-01-31
申请号：US11845597
申请日：2007-08-27
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
IPC分类号： A61K31/535 , A61K31/17 , A61P19/02 , A61K31/495
CPC分类号： A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途，以及用于此类治疗的药物组合物。
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8.发明申请INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 失效使用ARYL和HETEROARYL取代的杂环类URAAS对RAF激酶的抑制作用公开(公告)号：US20080009527A1
公开(公告)日：2008-01-10
申请号：US11768533
申请日：2007-06-26
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/4439 , A61K31/415 , A61P35/00 , C07D401/12 , C07D405/04 , C07D231/38 , A61K31/443
CPC分类号： C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,
摘要翻译： 用raf激酶介导的肿瘤治疗方法，用取代的脲化合物和这些化合物本身，
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9.发明申请Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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10.发明授权Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders 失效可用于治疗癌症和其他疾病的取代嘧啶衍生物公开(公告)号：US08580798B2
公开(公告)日：2013-11-12
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12 , A61K31/506
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。
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