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1.发明申请2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 审中-公开用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US20050215594A1
公开(公告)日：2005-09-29
申请号：US11117759
申请日：2005-04-28
申请人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
发明人： Stephen O'Connor , Gaetan Ladouceur , William Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek Lowe , Steven Magnuson , Ning Qi , Tatiana Skelekhin , Quanrong Shen , Roger Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D45/02
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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2.发明申请公开(公告)号：US20060063760A1
公开(公告)日：2006-03-23
申请号：US10554390
申请日：2004-04-16
申请人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
发明人： Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
IPC分类号： A61K31/54 , A61K31/537 , A61K31/445 , A61K31/495 , A61K31/4172
CPC分类号： C07C259/06 , C07C311/08 , C07C311/29 , C07C317/32 , C07C2602/08 , C07D209/14 , C07D209/16 , C07D209/26 , C07D213/38 , C07D213/53 , C07D215/12 , C07D265/30 , C07D307/52 , C07D307/81 , C07D333/58 , C07D403/12 , C07D413/12
摘要： This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译： 本发明涉及式（I）化合物及其在治疗高增殖性疾病中的用途。
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3.发明授权Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US07423156B2
公开(公告)日：2008-09-09
申请号：US11341197
申请日：2006-01-27
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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4.发明申请Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US20090270468A1
公开(公告)日：2009-10-29
申请号：US12231878
申请日：2008-09-05
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Minghao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Minghao Zhang , Lei Zhu
IPC分类号： A61K31/428 , C07D277/82 , A61K31/423 , C07D263/58 , C07D235/30 , A61K31/4184 , A61P3/04
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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5.发明申请PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开用于治疗糖尿病的芳基酸衍生物的制备和使用公开(公告)号：US20090197795A1
公开(公告)日：2009-08-06
申请号：US12185813
申请日：2008-08-04
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , A61K38/28 , A61P3/10 , A61K38/22 , A61P3/04 , A61K31/423 , A61K31/426 , A61K31/4184 , C07D277/82 , C07D235/30 , C07D277/38 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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公开(公告)号：US20090253762A1
公开(公告)日：2009-10-08
申请号：US12206721
申请日：2008-09-08
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , C07D277/82 , C07D413/02 , A61K31/416 , A61K31/423 , C07D405/02
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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公开(公告)号：US07091228B2
公开(公告)日：2006-08-15
申请号：US10839833
申请日：2004-05-06
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , A61K31/426 , C07D277/82 , C07D277/42
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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公开(公告)号：US20060194859A1
公开(公告)日：2006-08-31
申请号：US11341197
申请日：2006-01-27
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/5377 , A61K31/4184 , C07D235/30
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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9.发明申请Preparation and Use of Biphenyl-4-Yl-Carbonylamino Acid Derivatives for the Treatment of Obesity 失效联苯-4-基羰基氨基酸衍生物用于治疗肥胖症的制备与应用公开(公告)号：US20070265298A1
公开(公告)日：2007-11-15
申请号：US11665317
申请日：2005-10-14
申请人： Roger Smith , Stephen O'Connor , Philip Coish , Derek Lowe , Roger Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen O'Connor , Philip Coish , Derek Lowe , Roger Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/435 , A61K31/421 , A61K31/44 , C07D277/00 , C07D471/02 , A61P7/12 , A61K31/426
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。
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![Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases](/abs-image/US/2013/04/30/US08431695B2/abs.jpg.150x150.jpg)
10.发明授权Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号：US08431695B2
公开(公告)日：2013-04-30
申请号：US12084411
申请日：2006-11-02
申请人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号： C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译： 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
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