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1.发明授权Method and system for automated focus-distance determination for molecular array scanners 失效分子阵列扫描仪的自动聚焦距离测定方法和系统公开(公告)号：US06770892B2
公开(公告)日：2004-08-03
申请号：US10086743
申请日：2002-02-28
IPC分类号： G01T2164
CPC分类号： G01N21/6452 , G01N21/6458 , G01N2021/6463
摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.
摘要翻译： 一种用于确定用于扫描分子阵列扫描仪的最佳聚焦距离的自动化方法和系统。 参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。 然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。
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公开(公告)号：US07247494B2
公开(公告)日：2007-07-24
申请号：US10788547
申请日：2004-02-27
申请人： John F. Corson , Russell A. Parker
发明人： John F. Corson , Russell A. Parker
IPC分类号： G01N21/00 , G01N27/416 , C12Q1/68 , B32B5/02 , G01N7/00
CPC分类号： G01N21/15 , Y10T436/212
摘要： A reader is provided that, itself, addresses the issue of damage or degradation to arrays within the reader by virtue of air exposure. In doing so, experimental variability is reduced, and read/scan signal strength degradation is minimized for arrays/slides scanned or otherwise read toward the end of a run. The subject scanners employ a filter that reduces the amount of chemicals in the air inside the device that are harmful to the array, or the dye on the array. The implementation of adding a chemical filter to the reader device may be such that air is either drawn into or, alternatively, pushed through the filter into the same. It is possible that the entirety of the device may be provided with filtered air, or just the region holding slides to be scanned. Array readers so-constructed as well as associated methodology involving filtering incoming air while reading arrays are covered.
摘要翻译： 提供了一种阅读器，其本身通过空气曝光来解决读取器内的阵列的损坏或劣化的问题。 在这样做时，实验变异性降低，并且读/扫描信号强度退化被最小化以扫描或以其它方式读取到运行结束的阵列/幻灯片。 主题扫描仪采用一种过滤器，可以减少设备内对空气有害的化学物质量，或阵列上的染料。 向读取器装置添加化学过滤器的实现可以是这样的，即空气被吸入或者被抽入过滤器中。 可能的是，整个设备可以设置有过滤的空气，或者只是保持待扫描的幻灯片的区域。 涵盖了如此构造的阵列读取器以及在读取阵列时过滤进入的空气的相关方法。
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公开(公告)号：US06929951B2
公开(公告)日：2005-08-16
申请号：US10086932
申请日：2002-02-28
CPC分类号： G01N21/6452 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6456 , Y10T436/10
摘要： A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant signal-intensity-to-label-concentration ratio. In the first step of the two-step calibration method, a reference array coated with the fluorophore or chromophore used to label probe molecules is employed, while in the second step of the two-step method, a reference array coated with a stable dye is employed.
摘要翻译： 用于将分子阵列校准为参考分子阵列的方法和系统，并且用于随后校准分子阵列以维持恒定的信号强度与标记 - 浓度比。 在两步校准方法的第一步中，使用涂布有用于标记探针分子的荧光团或发色团的参考阵列，而在两步法的第二步中，涂有稳定染料的参考阵列是 雇用。
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4.发明授权公开(公告)号：US07205045B2
公开(公告)日：2007-04-17
申请号：US10944457
申请日：2004-09-16
IPC分类号： G11B11/105
CPC分类号： G01N21/278 , G01N21/6428 , G01N21/6452 , Y10T428/26 , Y10T428/268
摘要： Calibration devices for optical scanners and methods for their use are provided. The subject devices are characterized by having a polymeric coating with at least one fluorescent agent, where the devices have minimal local and global nonuniformities. The subject device may also include one or more photobleached regions. In using the subject devices, a surface is illuminated with at least one light source, fluorescence data is obtained from the surface and the optical system is calibrated based upon the obtained fluorescence data. The subject invention finds use in a variety of optical scanners, including biopolymeric array optical scanners. Also provided are kits for use in verifying and calibrating optical scanners.
摘要翻译： 提供了用于光学扫描仪的校准装置及其使用方法。 本发明装置的特征在于具有至少一种荧光剂的聚合物涂层，其中装置具有最小的局部和全局不均匀性。 主体装置还可以包括一个或多个照相漂白区域。 在使用目标装置时，用至少一个光源照射表面，从表面获得荧光数据，并且基于获得的荧光数据校准光学系统。 本发明可用于各种光学扫描仪，包括生物聚合物阵列光学扫描仪。 还提供了用于验证和校准光学扫描仪的套件。
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公开(公告)号：US20080200341A1
公开(公告)日：2008-08-21
申请号：US12113388
申请日：2008-05-01
IPC分类号： C40B30/00
CPC分类号： C12Q1/6837 , B01J2219/00333 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/508 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B82Y30/00
摘要： Devices and methods for performing an array assay are provided. Embodiments of the subject array assay devices include (1) a base, (2) a cover, and (3) a clamping member for holding the cover to the base, wherein when the cover is operatively held to the base about a structure that includes an array assembly spaced-apart from a backing element, the array assembly and the backing element are deflected to substantially the same curvature. Embodiments of the subject methods include contacting a sample with a backing element and placing the backing element supported sample in contact with an array assembly to form a structure that includes the backing element and array assembly. The structure is then held together using a subject array assay device and the array substrate and the backing element are deflected to substantially the same curvature.
摘要翻译： 提供了用于进行阵列测定的装置和方法。 本发明的阵列测定装置的实施例包括（1）底座，（2）盖子和（3）用于将盖子保持在基座上的夹紧构件，其中当盖子围绕包括 与背衬元件间隔开的阵列组件，阵列组件和背衬元件被偏转到基本上相同的曲率。 本发明方法的实施方案包括将样品与背衬元件接触并将支撑元件支撑的样品与阵列组件接触以形成包括背衬元件和阵列组件的结构。 然后使用主题阵列测定装置将结构保持在一起，并且阵列基板和背衬元件被偏转到基本上相同的曲率。
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6.发明授权公开(公告)号：US06794424B2
公开(公告)日：2004-09-21
申请号：US10008598
申请日：2001-12-04
IPC分类号： G21F110
CPC分类号： G01N21/278 , G01N21/6428 , G01N21/6452 , Y10T428/26 , Y10T428/268
摘要： Calibration devices for optical scanners and methods for their use are provided. The subject devices are characterized by having a polymeric coating with at least one fluorescent agent, where the devices have minimal local and global nonuniformities. The subject device may also include one or more photobleached regions. In using the subject devices, a surface is illuminated with at least one light source, fluorescence data is obtained from the surface and the optical system is calibrated based upon the obtained fluorescence data. The subject invention finds use in a variety of optical scanners, including biopolymeric array optical scanners. Also provided are kits for use in verifying and calibrating optical scanners.
摘要翻译： 提供了用于光学扫描仪的校准装置及其使用方法。 本发明装置的特征在于具有至少一种荧光剂的聚合物涂层，其中装置具有最小的局部和全局不均匀性。 主体装置还可以包括一个或多个照相漂白区域。 在使用目标装置时，用至少一个光源照射表面，从表面获得荧光数据，并且基于获得的荧光数据校准光学系统。 本发明可用于各种光学扫描仪，包括生物聚合物阵列光学扫描仪。 还提供了用于验证和校准光学扫描仪的套件。
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7.发明授权
公开(公告)号：US5474793A
公开(公告)日：1995-12-12
申请号：US240542
申请日：1994-05-10
申请人： Larry E. Meyer , Russell A. Parker
发明人： Larry E. Meyer , Russell A. Parker
摘要： A process for preparing calcium-supplemented, ready-to-serve, not-from-concentrate (NFC) fruit juice beverages is disclosed. This process involves circulating an acidified NFC juice stream containing citric and malic acid from a blend tank through a mixing zone that creates turbulent flow. A powdered source of calcium is then added to this acidified juice stream in the mixing zone. The calcium supplemented juice is recirculated back to the blend tank until the acidified juice comprises from about 0.05 to about 0.26% by weight solubilized calcium.
摘要翻译： 公开了一种制备钙补充的，即食的，不是浓缩的（NFC）果汁饮料的方法。 该方法包括将含有柠檬酸和苹果酸的酸化的NFC果汁流从混合罐循环通过产生湍流的混合区。 然后在混合区中向该酸化的果汁流中加入粉末状钙源。 钙补充的果汁再循环回混合罐，直到酸化的果汁包含约0.05至约0.26重量％的溶解的钙。
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公开(公告)号：US4429049A
公开(公告)日：1984-01-31
申请号：US350689
申请日：1982-02-22
CPC分类号： G01N25/14 , B01D11/04 , Y10T436/163333 , Y10T436/255
摘要： A process for the analysis of organic pollutants from an aqueous sample is provided including injecting an extraction solvent under pressure in the form of a plurality of substantially uniform droplets into the sample containing one or more pollutants. The solvent droplets are collected and then analyzed for the presence of the pollutants. The apparatus includes a sample holding column, a solvent reservoir, a source of gas under pressure, and a nozzle having one or more outlet ports which subdivides the solvent into small uniform droplets to enhance mass transfer of pollutants from the sample into the solvent.
摘要翻译： 提供了一种用于从含水样品中分析有机污染物的方法，包括在多个基本均匀的液滴形式的压力下将提取溶剂注入含有一种或多种污染物的样品中。 收集溶剂液滴，然后分析污染物的存在。 该装置包括样品保持柱，溶剂储存器，压力下的气体源和具有一个或多个出口的喷嘴，其将溶剂细分成小的均匀液滴，以增强污染物从样品到溶剂的传质。
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公开(公告)号：US4364655A
公开(公告)日：1982-12-21
申请号：US236055
申请日：1981-02-19
申请人： Russell A. Parker
发明人： Russell A. Parker
CPC分类号： G03D13/007 , Y10T307/951
摘要： Process timing and controlling system for use in photographic darkrooms involving multiple timing and control process steps including a control console, programmable in at least one channel to step through substantially all timing and control process steps, timing means in at least one channel for measuring time remaining in a particular process step, timing indicator means in at least one channel for indicating time remaining in a particular process step, a source of power connecting the console and the timing means which when activated supplies power to the console and timing mean, means for initiating a program step in at least one channel, switching means in at least one channel for stepping through the steps independently of the programmed time, a plurality of relays for operating programmed timing and control functions, and relay driving means programmed to select an appropriate output to activate the relay.
摘要翻译： 用于照相暗室中的处理定时和控制系统，其涉及多个定时和控制过程步骤，包括控制台，可在至少一个通道中编程，以逐步通过基本上所有的定时和控制过程步骤，至少一个通道中的定时装置用于测量剩余时间 在特定的处理步骤中，在至少一个通道中指示用于指示在特定处理步骤中剩余的时间的定时指示器，连接控制台的电源和定时装置，当被激活向控制台供电并且定时平均时，启动装置 至少一个通道中的程序步骤，至少一个通道中的切换装置，用于独立于编程时间步进步骤，用于操作编程定时和控制功能的多个继电器，以及被编程为选择适当输出的中继驱动装置 激活继电器
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