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    Method of chemical imaging to determine tissue margins during surgery
    5.
    发明授权
    Method of chemical imaging to determine tissue margins during surgery 有权
    化学成像方法来确定手术中的组织边缘

    公开(公告)号：US07596404B2

    公开(公告)日：2009-09-29

    申请号：US11361256

    申请日：2006-02-24

    申请人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    发明人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    IPC分类号： A61B6/00

    CPC分类号： G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

    摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

    摘要翻译： 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

    Automated acquisition of spectral data and image data
    6.
    发明申请
    Automated acquisition of spectral data and image data 有权
    自动采集光谱数据和图像数据

    公开(公告)号：US20070133984A1

    公开(公告)日：2007-06-14

    申请号：US11585535

    申请日：2006-10-24

    申请人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： H04B10/08 ,  H04B17/00

    CPC分类号： G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    Method and apparatus for spectral modulation compensation
    7.
    发明申请
    Method and apparatus for spectral modulation compensation 有权
    光谱调制补偿的方法和装置

    公开(公告)号：US20060001867A1

    公开(公告)日：2006-01-05

    申请号：US10879632

    申请日：2004-06-30

    申请人： John Maier ,  Jason Neiss ,  Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    发明人： John Maier ,  Jason Neiss ,  Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/65 ,  G01J3/0297 ,  G01J3/44 ,  G01N2021/656

    摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.

    摘要翻译： 本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。 因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。 因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

    Automated acquisition of spectral data and image data
    8.
    发明授权
    Automated acquisition of spectral data and image data 有权
    自动采集光谱数据和图像数据

    公开(公告)号：US07557915B2

    公开(公告)日：2009-07-07

    申请号：US11585535

    申请日：2006-10-24

    申请人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： G01J3/44

    CPC分类号： G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection
    9.
    发明申请
    Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection 审中-公开
    使用脉冲激光激发和时间门控检测的威胁剂的拉曼化学成像

    公开(公告)号：US20100309464A1

    公开(公告)日：2010-12-09

    申请号：US12619336

    申请日：2009-11-16

    申请人： Patrick J. Treado ,  Matthew Nelson ,  Jeffrey Cohen ,  John Maier

    发明人： Patrick J. Treado ,  Matthew Nelson ,  Jeffrey Cohen ,  John Maier

    IPC分类号： G01J3/44

    CPC分类号： G01J3/2803 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/2889 ,  G01J3/44 ,  G01N21/274 ,  G01N21/65 ,  G01N2201/0216 ,  G01N2201/0697

    摘要： The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection.

    摘要翻译： 本公开提供了用于检测威胁代理的系统和方法。 样品被照亮以产生被样品分散和发射的光子拉曼。 使用时间门控检测收集拉曼散射的光子，而不收集发射的光子。 从所述拉曼散射光子产生拉曼光谱数据集，其中所述拉曼光谱数据包括拉曼光谱和拉曼化学图像中的至少一个。 评估拉曼光谱数据，从而确定样品中威胁剂的存在或不存在。 样本可能在目标区域。 可以使用脉冲激光或强度调制激光来照亮样品。 照明源可以与启用时间门控检测的门控元件同步。

    System and method for spectroscopy and imaging
    10.
    发明申请
    System and method for spectroscopy and imaging 审中-公开
    用于光谱和成像的系统和方法

    公开(公告)号：US20060001868A1

    公开(公告)日：2006-01-05

    申请号：US10879633

    申请日：2004-06-30

    申请人： Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    发明人： Shona Stewart ,  Matthew Nelson ,  Joseph Demuth ,  Patrick Treado

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01J3/0297 ,  G01N21/65

    摘要： The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

    摘要翻译： 本公开涉及用于通过光学成像光谱法的拉曼进行光谱表征的生物材料的改进的检测，分辨和成像的基底材料。 衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。 此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。 本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。