利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

63 条记录 (耗时 0.028 秒)

    Method of chemical imaging to determine tissue margins during surgery
    4.
    发明授权
    Method of chemical imaging to determine tissue margins during surgery 有权
    化学成像方法来确定手术中的组织边缘

    公开(公告)号：US07596404B2

    公开(公告)日：2009-09-29

    申请号：US11361256

    申请日：2006-02-24

    申请人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    发明人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    IPC分类号： A61B6/00

    CPC分类号： G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

    摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

    摘要翻译： 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

    Raman Characterization of Transplant Tissue
    5.
    发明申请
    Raman Characterization of Transplant Tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US20100034743A1

    公开(公告)日：2010-02-11

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    IPC分类号： A61K49/00 ,  G01J3/44 ,  G01N21/65 ,  A61P43/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Raman characterization of transplant tissue
    6.
    发明授权
    Raman characterization of transplant tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US08253936B2

    公开(公告)日：2012-08-28

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    IPC分类号： G01J3/44

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection
    7.
    发明申请
    Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection 审中-公开
    使用脉冲激光激发和时间门控检测的威胁剂的拉曼化学成像

    公开(公告)号：US20100309464A1

    公开(公告)日：2010-12-09

    申请号：US12619336

    申请日：2009-11-16

    申请人： Patrick J. Treado ,  Matthew Nelson ,  Jeffrey Cohen ,  John Maier

    发明人： Patrick J. Treado ,  Matthew Nelson ,  Jeffrey Cohen ,  John Maier

    IPC分类号： G01J3/44

    CPC分类号： G01J3/2803 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/2889 ,  G01J3/44 ,  G01N21/274 ,  G01N21/65 ,  G01N2201/0216 ,  G01N2201/0697

    摘要： The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection.

    摘要翻译： 本公开提供了用于检测威胁代理的系统和方法。 样品被照亮以产生被样品分散和发射的光子拉曼。 使用时间门控检测收集拉曼散射的光子，而不收集发射的光子。 从所述拉曼散射光子产生拉曼光谱数据集，其中所述拉曼光谱数据包括拉曼光谱和拉曼化学图像中的至少一个。 评估拉曼光谱数据，从而确定样品中威胁剂的存在或不存在。 样本可能在目标区域。 可以使用脉冲激光或强度调制激光来照亮样品。 照明源可以与启用时间门控检测的门控元件同步。

    System and method for diagnosis tissue samples using fluorescence and raman techniques
    9.
    发明申请
    System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
    使用荧光和拉曼技术诊断组织样本的系统和方法

    公开(公告)号：US20120078524A1

    公开(公告)日：2012-03-29

    申请号：US13136366

    申请日：2011-07-29

    申请人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    发明人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    IPC分类号： G01N33/48 ,  G01N21/64 ,  G01J3/44

    CPC分类号： A61B5/0059 ,  A61B5/417 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/6458 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/16 ,  G02B21/365 ,  G06F19/325 ,  G16H50/70

    摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.

    摘要翻译： 用于确定测试生物样品的诊断的系统和方法。 一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生 所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。 一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。 可以评估该拉曼数据集以确定样品的诊断。 诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging
    10.
    发明授权
    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging 有权
    使用拉曼分子成像区分浸润性导管癌和浸润性小叶癌

    公开(公告)号：US07956996B2

    公开(公告)日：2011-06-07

    申请号：US12206500

    申请日：2008-09-08

    申请人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    发明人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/02 ,  A61B5/0059 ,  A61B5/417 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  Y02A90/26

    摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

    摘要翻译： 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。