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    Method of chemical imaging to determine tissue margins during surgery
    4.
    发明授权
    Method of chemical imaging to determine tissue margins during surgery 有权
    化学成像方法来确定手术中的组织边缘

    公开(公告)号：US07596404B2

    公开(公告)日：2009-09-29

    申请号：US11361256

    申请日：2006-02-24

    申请人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    发明人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    IPC分类号： A61B6/00

    CPC分类号： G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

    摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

    摘要翻译： 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

    Raman Characterization of Transplant Tissue
    5.
    发明申请
    Raman Characterization of Transplant Tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US20100034743A1

    公开(公告)日：2010-02-11

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    IPC分类号： A61K49/00 ,  G01J3/44 ,  G01N21/65 ,  A61P43/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Raman spectral analysis of pathogens
    8.
    发明授权
    Raman spectral analysis of pathogens 有权
    拉曼光谱分析病原体

    公开(公告)号：US07428045B2

    公开(公告)日：2008-09-23

    申请号：US11206007

    申请日：2005-08-17

    申请人： Shona Stewart ,  John S. Maier ,  Patrick J. Treado

    发明人： Shona Stewart ,  John S. Maier ,  Patrick J. Treado

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/65 ,  A61B18/20 ,  G01J3/10 ,  G01J3/44 ,  G01N21/31 ,  G01N21/645 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/658 ,  G01N2021/6423 ,  G01N2021/656

    摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.

    摘要翻译： 使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。 该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。 使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。 本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。