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1.发明授权Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 有权使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US07771979B2
公开(公告)日：2010-08-10
申请号：US11712044
申请日：2007-02-27
申请人： John Polo , Thomas W. Dubensky, Jr. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
发明人： John Polo , Thomas W. Dubensky, Jr. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC分类号： C07K14/005 , A61K35/00 , A61K2039/5256 , C12N15/86 , C12N2740/16122 , C12N2770/36143
摘要： Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
摘要翻译： 提供了使用基于甲病毒的载体系统产生免疫应答的方法。
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2.发明申请Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems 失效用于产生使用基于甲病毒的载体系统的免疫应答的组合物和方法公开(公告)号：US20100266631A1
公开(公告)日：2010-10-21
申请号：US12825722
申请日：2010-06-29
申请人： John Polo , Thomas W. Dubensky, JR. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
发明人： John Polo , Thomas W. Dubensky, JR. , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2740/16134 , C12N2740/16234 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36145 , C12N2810/609
摘要： Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
摘要翻译： 提供了用于真核分层载体启动系统和甲病毒复制子颗粒的组合物和方法，用于将异源序列引入细胞以产生免疫应答。
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3.发明授权Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 失效使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US08647864B2
公开(公告)日：2014-02-11
申请号：US12825722
申请日：2010-06-29
申请人： John M Polo , Thomas W Dubensky, Jr. , Ilya Frolov , Jason P Gardner , Gillis Otten , Susan Barnett , David A Driver
发明人： John M Polo , Thomas W Dubensky, Jr. , Ilya Frolov , Jason P Gardner , Gillis Otten , Susan Barnett , David A Driver
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2740/16134 , C12N2740/16234 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36145 , C12N2810/609
摘要： Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.
摘要翻译： 提供了用于真核分层载体启动系统和甲病毒复制子颗粒的组合物和方法，用于将异源序列引入细胞以产生免疫应答。
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4.发明申请Compositions and methods for generating an immune response utilizing alphavirus-based vector systems 有权使用基于甲病毒的载体系统产生免疫应答的组合物和方法公开(公告)号：US20080226598A1
公开(公告)日：2008-09-18
申请号：US11712044
申请日：2007-02-27
申请人： John Polo , Thomas W. Dubensky , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
发明人： John Polo , Thomas W. Dubensky , Ilya Frolov , Jason P. Gardner , Gillis Otten , Susan Barnett , David A. Driver
CPC分类号： C07K14/005 , A61K35/00 , A61K2039/5256 , C12N15/86 , C12N2740/16122 , C12N2770/36143
摘要： Methods are provided for generating immune responses utilizing alphavirus-based vector systems.
摘要翻译： 提供了使用基于甲病毒的载体系统产生免疫应答的方法。
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5.发明授权公开(公告)号：US06451592B1
公开(公告)日：2002-09-17
申请号：US08944465
申请日：1997-10-06
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
IPC分类号： C12N1500
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
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6.发明授权公开(公告)号：US06465634B1
公开(公告)日：2002-10-15
申请号：US09415900
申请日：1999-10-08
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
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7.发明授权Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis 有权基于重组甲病毒的载体具有抑制细胞大分子合成的作用公开(公告)号：US06391632B1
公开(公告)日：2002-05-21
申请号：US09415784
申请日：1999-10-08
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
IPC分类号： C12N510
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as is compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质，与野生型重组甲病毒颗粒相比。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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8.发明申请RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACRO-MOLECULAR SYNTHESIS 审中-公开基于重组腺病毒的载体，具有减少细胞宏观分子合成的抑制作用公开(公告)号：US20100330121A1
公开(公告)日：2010-12-30
申请号：US12845516
申请日：2010-07-28
申请人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
发明人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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9.发明授权Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis 失效基于重组甲病毒的载体具有抑制细胞大分子合成的作用公开(公告)号：US07811812B2
公开(公告)日：2010-10-12
申请号：US10391441
申请日：2003-03-17
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Drvga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Drvga , Ilya Frolov
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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公开(公告)号：US06426196B1
公开(公告)日：2002-07-30
申请号：US09415785
申请日：1999-10-08
IPC分类号： C12P2106
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed. comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子。 包括甲型病毒非结构蛋白基因，当与野生型相比，当可操作地并入重组甲病毒颗粒中时，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平，并且相同或 与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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