公开(公告)号：US20110093086A1

公开(公告)日：2011-04-21

申请号：US12978069

申请日：2010-12-23

Applicant: Tyler D. Witt ,  Jason D. Meridew ,  John R. White ,  Troy W. Hershberger ,  Robert Metzger

Inventor： Tyler D. Witt ,  Jason D. Meridew ,  John R. White ,  Troy W. Hershberger ,  Robert Metzger

IPC: A61F2/32

CPC classification number: A61F2/3603 ,  A61B17/151 ,  A61B17/152 ,  A61B34/10 ,  A61B2034/105 ,  A61B2034/108 ,  A61B2034/252 ,  A61F2/30771 ,  A61F2/34 ,  A61F2/3609 ,  A61F2/4609 ,  A61F2002/302 ,  A61F2002/30604 ,  A61F2002/30617 ,  A61F2002/30736 ,  A61F2002/30878 ,  A61F2002/30934 ,  A61F2002/30952 ,  A61F2002/30962 ,  A61F2002/4633 ,  A61F2002/4662 ,  A61F2002/4668 ,  A61F2002/4687 ,  B33Y80/00

Abstract: A patient-specific acetabular resection guide includes a dome-shaped surface bounded by a periphery. The dome-shaped surface is a three-dimensional patient-specific surface designed to anatomically match and be received into an acetabulum of the patient, based on a three-dimensional image of a hip joint of the patient reconstructed from a medical scan of the hip joint. The resection guide includes a plurality of guiding formations defined on the resection guide and having patient-specific shapes and orientations for guiding corresponding osteotomies relative to the acetabulum for correcting hip dysplasia.

Abstract translation: 患者特异性髋臼切除引导件包括由周边界定的圆顶形表面。 圆顶形表面是根据从髋关节的医学扫描重建的患者的髋关节的三维图像，设计用于解剖匹配并被接纳到患者的髋臼中的三维患者特异性表面 联合。 切除引导件包括限定在切除引导件上的多个引导结构，并且具有用于引导相对于髋臼的相应截骨的患者特定形状和取向，用于矫正髋关节发育不良。

公开(公告)号：US07712358B2

公开(公告)日：2010-05-11

申请号：US11729091

申请日：2007-03-27

Applicant: Richard G. Kingsbury ,  John R. White

Inventor： Richard G. Kingsbury ,  John R. White

IPC: G01M15/00

CPC classification number: G01M13/02 ,  G01M13/025

Abstract: A drive line (A) for testing a component (D) of a drive train of a vehicle comprises a torque sensor. The torque sensor measures AC variations in torque due to the operation of the component (D). The component (D) is coupled to the drive line by an adapter having a coupling for coupling the drive line to the axle. The torque sensor may output both AC and DC components of measured torque variation. A servo controller controls the drive line so that the drive line is driven into abutment with the axle and then backed off by a small preset distance.

Abstract translation: 用于测试车辆的传动系的部件（D）的驱动线（A）包括转矩传感器。 扭矩传感器测量由于部件（D）的操作导致的扭矩的AC变化。 组件（D）通过具有用于将驱动线耦合到轴的联接器的适配器联接到驱动线。 扭矩传感器可以输出测量的扭矩变化的交流和直流分量。 伺服控制器控制驱动线，使得驱动线被驱动与轴抵接，然后以小的预设距离退回。

公开(公告)号：US20090254093A1

公开(公告)日：2009-10-08

申请号：US12486992

申请日：2009-06-18

Applicant: John R. White ,  Kurt Schmidt ,  Troy W. Hershberger ,  Thomas C. Raish ,  Ryan J. Schoenefeld ,  William J. Hamman ,  Jason D. Meridew ,  Tyler D. Witt

Inventor： John R. White ,  Kurt Schmidt ,  Troy W. Hershberger ,  Thomas C. Raish ,  Ryan J. Schoenefeld ,  William J. Hamman ,  Jason D. Meridew ,  Tyler D. Witt

IPC: A61B17/58

CPC classification number: A61B17/175 ,  A61B34/10 ,  A61B2017/00526 ,  A61B2017/568

Abstract: An orthopedic apparatus includes an alignment guide attachable to one of a femoral joint surface of a femur of a patient. The alignment guide has a patient-specific three-dimensional engagement surface, and at least one guiding portion defining a guiding passage. The engagement surface anatomically matches a corresponding portion of the femoral joint surface.

Abstract translation: 矫形装置包括可附接到患者的股骨的股骨关节表面中的一个的对准引导件。 对准引导件具有患者特定的三维接合表面和限定引导通道的至少一个引导部分。 接合表面解剖学地匹配股骨关节表面的相应部分。

公开(公告)号：US20090088374A1

公开(公告)日：2009-04-02

申请号：US11813288

申请日：2006-01-06

Applicant: Judithann Lee ,  Qin Lu ,  John R. White

Inventor： Judithann Lee ,  Qin Lu ,  John R. White

IPC: A61K38/16

CPC classification number: A61K38/17

Abstract: The present invention relates generally to the use of PA126 polypeptides and polynucleotides for healing various wounds arising from different causes.

Abstract translation: 本发明一般涉及PA126多肽和多核苷酸用于治疗由不同原因引起的各种伤口。

公开(公告)号：US06713052B1

公开(公告)日：2004-03-30

申请号：US09567225

申请日：2000-05-09

Applicant: John R. White ,  Louis Pelus ,  Haodong Li ,  Brendt L. Kreider

Inventor： John R. White ,  Louis Pelus ,  Haodong Li ,  Brendt L. Kreider

IPC: A61K3819

CPC classification number: C07K14/523 ,  A61K38/00 ,  Y10S930/14

Abstract: Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.

Abstract translation: 提供用于动员干细胞的新型趋化因子。 还提供了移动干细胞的方法。

公开(公告)号：US4736826A

公开(公告)日：1988-04-12

申请号：US726012

申请日：1985-04-22

Applicant: John R. White ,  Paul E. Satterlee, Jr. ,  Kenneth L. Walker ,  Howard W. Harvey

Inventor： John R. White ,  Paul E. Satterlee, Jr. ,  Kenneth L. Walker ,  Howard W. Harvey

IPC: B25J5/00 ,  B25J9/00 ,  B25J19/00 ,  G21F7/06 ,  H02G11/02 ,  H02G11/00

CPC classification number: B25J5/007 ,  B25J19/0029 ,  B25J9/0003 ,  G05D1/0272 ,  G21F7/06 ,  H02G11/02 ,  G05D2201/0211

Abstract: A mobile robot remotely controlled and/or powered through a cable from a stationary console is provided. The robot carries a cable management arrangement which stores the cable and dispenses and retracts it as needed. The arrangement lays down the cable under zero tension when the robot is outbound and reels it in as the robot returns to allow the robot to follow a tortuous path without entangling the cable under or around obstacles. The robot can have numerous configurations such as a simple configuration for use as a transporter for mail in an office and parts in a factory, to a complex configuration with robotic arms and sensors for use in remote surveillance and security work. The robot is especially usable in hostile environments such as nuclear power plants and has a containment box permitting it to be moved to numerous locations without contaminating other areas.

Abstract translation: 提供了通过来自固定控制台的电缆远程控制和/或供电的移动机器人。 机器人携带电缆管理装置，其存储电缆并根据需要进行分配和收回。 当机器人出站并在机器人返回时将机器人卷起，允许机器人沿着曲折路径，而不使电缆在障碍物下方或周围缠绕，该布置在零张力下铺设电缆。 机器人可以具有许多配置，例如用作办公室和工厂中的部件的邮件的运输机的简单配置，具有用于远程监视和安全工作的机器人手臂和传感器的复杂配置。 该机器人特别适用于诸如核电厂等恶劣环境，并具有容纳箱，允许其移动到多个位置而不污染其他区域。

公开(公告)号：US4689106A

公开(公告)日：1987-08-25

申请号：US721854

申请日：1985-04-10

Applicant: Cletus A. Becht ,  Peter M. Cressman ,  William J. Head ,  John R. White

Inventor： Cletus A. Becht ,  Peter M. Cressman ,  William J. Head ,  John R. White

IPC: B29C45/00 ,  B29D30/26 ,  B29D30/44 ,  B29D30/58 ,  B29K75/00

CPC classification number: B29D30/2607

Abstract: Spacer segments (24) of various thicknesses are attached to radially movable master segments (14) of a transfer ring (16) for gripping and transferring tread belt packages of different diameters. The spacer segments (24) are of a resilient material and may have molded arm members (32) with flexible, resilient ribs (42) for engaging edge portions (46) of the master segments (14). Handles (70) may be provided on the arm members (32) for bending the arm members (32) to install and remove the spacer segments (24). Axial movement of the spacer segments (24) relative to the master segments (14) is limited by circumferentially extending raised edges (58,60,66,68) on the cylindrical mating surfaces (26,28) of the master segments (14) and the spacer segments (24).

Abstract translation: 各种厚度的间隔段（24）附接到用于夹持和传送不同直径的胎面带包装件的传送环（16）的可径向移动的主区段（14）。 间隔段（24）是弹性材料，并且可以具有用于接合主段（14）的边缘部分（46）的柔性弹性肋（42）的模制臂构件（32）。 手柄（70）可以设置在臂构件（32）上，用于弯曲臂构件（32）以安装和移除间隔段（24）。 间隔段（24）相对于主段（14）的轴向运动受到主段（14）的圆柱形配合表面（26,28）上周向延伸的凸缘（58,60,66,68）的限制， 和间隔段（24）。

公开(公告)号：US20180256258A1

公开(公告)日：2018-09-13

申请号：US15919139

申请日：2018-03-12

Applicant: Seth Anderson Nash ,  John R. White ,  Annelise Galloway ,  Jody L. Claypool

Inventor： Seth Anderson Nash ,  John R. White ,  Annelise Galloway ,  Jody L. Claypool

IPC: A61B34/10 ,  G06T19/00

Abstract: Systems and methods for using an augmented reality device during patient diagnosis. A method may include capturing an image of a patient, and presenting using an augmented reality display, while permitting the patient to be viewed through the augmented reality display, a virtual feature corresponding to anatomy of the patient obtained from the image. The method may include detecting impingement of the anatomy of the patient based on the image and displaying on the augmented reality display, an indication of the impingement at the virtual feature, such as by changing an attribute of the virtual feature.

公开(公告)号：US09085622B2

公开(公告)日：2015-07-21

申请号：US13639918

申请日：2011-09-02

Applicant: Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

Inventor： Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/32 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract translation: 本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。 本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。

公开(公告)号：US08535387B2

公开(公告)日：2013-09-17

申请号：US13041665

申请日：2011-03-07

Applicant: Jason D. Meridew ,  John R. White ,  Robert Metzger

Inventor： Jason D. Meridew ,  John R. White ,  Robert Metzger

IPC: A61F2/36

CPC classification number: A61F2/3609 ,  A61B17/1624 ,  A61B17/164 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/809 ,  A61B34/10 ,  A61B2034/105 ,  A61B2034/108 ,  A61F2/30942 ,  A61F2/3601 ,  A61F2002/30574 ,  A61F2002/30617 ,  A61F2002/3645 ,  A61F2250/0097 ,  B33Y70/00 ,  B33Y80/00 ,  Y10T29/49826

Abstract: A method for preparing a femoral neck for receiving a neck implant includes obtaining image data of a proximal femoral bone and femoral neck of a patient by a medical imaging method and constructing a three-dimensional image model of the proximal femoral bone and neck of the patient using the image data. The method further includes identifying a three-dimensional cortical boundary surface at an interface between cortical and cancellous bone of the patient using the image model. A patient-specific broach having a three-dimensional cutting surface closely matching and complementary to the cortical boundary surface of the patient using the image model is designed and manufactured.

Abstract translation: 用于准备用于接收颈部植入物的股骨颈的方法包括通过医学成像方法获得患者的股骨近端和股骨颈的图像数据，并且构建患者的股骨近端和颈部的三维图像模型 使用图像数据。 该方法还包括使用图像模型在患者的皮层和松质骨之间的界面处识别三维皮质边界表面。 设计并制造具有与患者皮质边界表面紧密匹配并与图像模型互补的三维切割表面的患者特异性拉刀。