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    Raman Characterization of Transplant Tissue
    2.
    发明申请
    Raman Characterization of Transplant Tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US20100034743A1

    公开(公告)日：2010-02-11

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

    IPC分类号： A61K49/00 ,  G01J3/44 ,  G01N21/65 ,  A61P43/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Raman characterization of transplant tissue
    3.
    发明授权
    Raman characterization of transplant tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US08253936B2

    公开(公告)日：2012-08-28

    申请号：US12537513

    申请日：2009-08-07

    申请人： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    发明人： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    IPC分类号： G01J3/44

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    摘要翻译： 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Method of chemical imaging to determine tissue margins during surgery
    6.
    发明授权
    Method of chemical imaging to determine tissue margins during surgery 有权
    化学成像方法来确定手术中的组织边缘

    公开(公告)号：US07596404B2

    公开(公告)日：2009-09-29

    申请号：US11361256

    申请日：2006-02-24

    申请人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    发明人： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

    IPC分类号： A61B6/00

    CPC分类号： G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

    摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

    摘要翻译： 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

    System and method for diagnosis tissue samples using fluorescence and raman techniques
    7.
    发明申请
    System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
    使用荧光和拉曼技术诊断组织样本的系统和方法

    公开(公告)号：US20120078524A1

    公开(公告)日：2012-03-29

    申请号：US13136366

    申请日：2011-07-29

    申请人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    发明人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    IPC分类号： G01N33/48 ,  G01N21/64 ,  G01J3/44

    CPC分类号： A61B5/0059 ,  A61B5/417 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/6458 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/16 ,  G02B21/365 ,  G06F19/325 ,  G16H50/70

    摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.

    摘要翻译： 用于确定测试生物样品的诊断的系统和方法。 一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生 所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。 一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。 可以评估该拉曼数据集以确定样品的诊断。 诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging
    8.
    发明授权
    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging 有权
    使用拉曼分子成像区分浸润性导管癌和浸润性小叶癌

    公开(公告)号：US07956996B2

    公开(公告)日：2011-06-07

    申请号：US12206500

    申请日：2008-09-08

    申请人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    发明人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/02 ,  A61B5/0059 ,  A61B5/417 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  Y02A90/26

    摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

    摘要翻译： 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

    System and method for cytological analysis by raman spectroscopic imaging
    9.
    发明申请
    System and method for cytological analysis by raman spectroscopic imaging 审中-公开
    通过拉曼光谱成像进行细胞学分析的系统和方法

    公开(公告)号：US20070178067A1

    公开(公告)日：2007-08-02

    申请号：US11598248

    申请日：2006-11-09

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： A61K48/00 ,  C12Q1/00 ,  G06F19/00

    CPC分类号： G01N33/5005 ,  G01N15/1459 ,  G01N21/65 ,  G01N33/574 ,  G01N33/57407 ,  G01N2021/656

    摘要： A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a biological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.

    摘要翻译： 一种差异操纵细胞的方法和系统，其中悬浮在流体中的细胞用基本上单色的光照射。 从照射的细胞获得拉曼数据集，其中数据集是疾病状态的特征。 评估数据集以鉴定患病细胞。 还获得了照射的细胞的拉曼化学图像。 基于评估和拉曼化学图像，细胞悬浮的流体被差异地操纵。 病变细胞被引导到第一位置，并且其他非病变细胞被引导到第二位置作为差异操纵的一部分。 患病细胞可以用物理应力，化学应力和生物应激治疗，然后返回到在照射之前从其获得患病细胞的患者。