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公开(公告)号：US08524057B2
公开(公告)日：2013-09-03
申请号：US13193128
申请日：2011-07-28
申请人： Jonathan M. Rothberg , Wolfgang Hinz , Kim L. Johnson , James M. Bustillo , John H. Leamon , Jonathan Schultz
发明人： Jonathan M. Rothberg , Wolfgang Hinz , Kim L. Johnson , James M. Bustillo , John H. Leamon , Jonathan Schultz
IPC分类号： G01N27/414
CPC分类号： C12Q1/6874 , B01L3/502761 , B01L2300/046 , B01L2300/0663 , B01L2300/0851 , B01L2400/086 , C12Q1/6869 , G01N27/4145 , G01N27/4148 , C12Q2565/607 , C12Q2565/301 , C12Q2565/629
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.
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公开(公告)号：US08426898B2
公开(公告)日：2013-04-23
申请号：US12691923
申请日：2010-01-22
IPC分类号： G01N27/403
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/42324 , H01L29/78 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
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公开(公告)号：US08306757B2
公开(公告)日：2012-11-06
申请号：US12721458
申请日：2010-03-10
IPC分类号： C12Q1/68 , H01L29/739
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/42324 , H01L29/78 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
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公开(公告)号：US20110251078A1
公开(公告)日：2011-10-13
申请号：US13044330
申请日：2011-03-09
申请人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
发明人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
IPC分类号： C40B30/00
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
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公开(公告)号：US20100035252A1
公开(公告)日：2010-02-11
申请号：US12319140
申请日：2008-12-31
申请人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
发明人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
摘要翻译： 本发明提供了用于测序经受力的核酸的装置及其使用方法，并因此在张力下考虑。 所述方法可以采用但不依赖于外源可检测标记的核苷酸的引入。
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公开(公告)号：US08906617B2
公开(公告)日：2014-12-09
申请号：US13044361
申请日：2011-03-09
申请人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
发明人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
摘要翻译： 本发明提供了用于测序经受力的核酸的装置及其使用方法，并因此在张力下考虑。 所述方法可以采用但不依赖于外源可检测标记的核苷酸的引入。
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公开(公告)号：US20110251110A1
公开(公告)日：2011-10-13
申请号：US13044352
申请日：2011-03-09
申请人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
发明人： Jonathan M. Rothberg , John H. Leamon , John F. Davidson , Antoine M. Van Oijen , Wolfgang Hinz , Melville Davey , Bradley Hann , Jonathan Schultz
CPC分类号： C12Q1/6874 , C12Q2523/303 , C12Q2565/131 , C12Q2525/204 , C12Q2521/101 , C12Q2535/122
摘要： The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
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公开(公告)号：US20100137143A1
公开(公告)日：2010-06-03
申请号：US12474897
申请日：2009-05-29
申请人： Jonathan M. Rothberg , Wolfgang Hinz , John F. Davidson , Antoine M. van Oijen , John H. Leamon , Martin Huber
发明人： Jonathan M. Rothberg , Wolfgang Hinz , John F. Davidson , Antoine M. van Oijen , John H. Leamon , Martin Huber
CPC分类号： G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/4148 , H01L21/82 , C12Q2565/607
摘要： Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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公开(公告)号：US20100301398A1
公开(公告)日：2010-12-02
申请号：US12475311
申请日：2009-05-29
申请人： Jonathan M. Rothberg , James M. Bustillo , Mark J. Milgrew , Jonathan C. Schultz , David Marran , Todd M. Rearick , Kim L. Johnson
发明人： Jonathan M. Rothberg , James M. Bustillo , Mark J. Milgrew , Jonathan C. Schultz , David Marran , Todd M. Rearick , Kim L. Johnson
IPC分类号： H01L29/78 , H01L21/336
CPC分类号： G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/27 , G01N27/414 , Y10T29/49002
摘要： Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
摘要翻译： 涉及FET阵列的方法和装置，包括用于监测化学和/或生物反应的大型FET阵列，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。
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10.发明申请METHODS AND APPARATUS FOR HIGH-SPEED OPERATION OF A CHEMICALLY-SENSITIVE SENSOR ARRAY 有权化学敏感传感器阵列高速运行的方法与装置公开(公告)号：US20120293158A1
公开(公告)日：2012-11-22
申请号：US13556634
申请日：2012-07-24
IPC分类号： G01N27/00
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/42324 , H01L29/78 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22 , C12Q2565/607 , C12Q2565/301 , C12Q2533/101
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
摘要翻译： 与用于分析物测量的非常大规模的FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。 在一个实例中，chemFET阵列基于监测氢离子浓度（pH），其他分析物浓度变化和/或与DNA合成相关的化学过程相关联的结合事件的变化来促进DNA测序技术。
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