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    Micro-reservoir osmotic release systems and microtube array device
    3.
    发明授权
    Micro-reservoir osmotic release systems and microtube array device 有权
    微储层渗透释放系统和微管阵列装置

    公开(公告)号：US07534241B2

    公开(公告)日：2009-05-19

    申请号：US10668573

    申请日：2003-09-23

    申请人： Jonathan R. Coppeta ,  John T. Santini, Jr. ,  Scott A. Uhland

    发明人： Jonathan R. Coppeta ,  John T. Santini, Jr. ,  Scott A. Uhland

    IPC分类号： A61K9/22

    CPC分类号： A61M31/002 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/141 ,  A61M5/14276 ,  A61M5/14526 ,  A61M31/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M2005/14513 ,  A61M2037/0023 ,  A61M2205/0244 ,  A61M2205/0266

    摘要： Devices and methods are provided for controlled release of chemical molecules, such as drugs. One device comprises a plurality of reservoirs; a rupturable covering, such as a thin metal film, enclosing a first end of each reservoir; a release formulation in each reservoir comprising chemical molecules for release; an expanding material layer in each reservoir; and a semi-permeable membrane enclosing a second end of each reservoir distal the release formulation, the semi-permeable membrane being operable to permit selected molecules (e.g., water) from outside the reservoir to diffuse to the expanding material layer to expand the expanding material layer and displace the release formulation in an amount effective rupture the rupturable membrane and discharge the release formulation. The device may further comprises a reservoir cap covering semi-permeable membrane and means for selectively disintegrating the reservoir cap to initiate diffusion of fluid molecules from outside the reservoir and through the semi-permeable membrane.

    摘要翻译： 提供了用于控制释放化学分子（例如药物）的装置和方法。 一个装置包括多个储存器; 诸如薄金属膜的破裂覆盖物，其包围每个储存器的第一端; 每个储存器中的释放制剂包含用于释放的化学分子; 每个储存器中的膨胀材料层; 以及半透膜，其围绕所述释放制剂封闭每个储存器的第二端，所述半透膜可操作以允许从所述储存器外部的选定分子（例如水）扩散到所述膨胀材料层以膨胀所述膨胀材料 并将释放制剂置于有效破裂可破裂膜并排出释放制剂的量。 装置还可以包括覆盖半透膜的储存器盖和用于选择性地分解储存器盖以启动流体分子从储存器外部并通过半透膜的装置的装置。

    Hermetically sealed microchip reservoir devices
    5.
    发明授权
    Hermetically sealed microchip reservoir devices 有权
    密封微芯片油藏装置

    公开(公告)号：US07497846B2

    公开(公告)日：2009-03-03

    申请号：US11005391

    申请日：2004-12-06

    申请人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

    发明人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

    IPC分类号： A61M5/00 ,  A61K9/22

    CPC分类号： A61K9/0097

    摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

    摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

    Method and device for the controlled delivery of parathyroid hormone
    6.
    发明授权
    Method and device for the controlled delivery of parathyroid hormone 有权
    用于甲状旁腺激素受控递送的方法和装置

    公开(公告)号：US07497855B2

    公开(公告)日：2009-03-03

    申请号：US10654761

    申请日：2003-09-04

    申请人： Dennis Ausiello ,  John T. Santini, Jr. ,  Stephen J. Herman ,  James H. Prescott ,  Scott A. Uhland ,  John M. Maloney ,  Benjamin F. Polito

    发明人： Dennis Ausiello ,  John T. Santini, Jr. ,  Stephen J. Herman ,  James H. Prescott ,  Scott A. Uhland ,  John M. Maloney ,  Benjamin F. Polito

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K9/0036 ,  A61K9/0097 ,  A61K38/29 ,  A61K2300/00

    摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

    摘要翻译： 提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。 所述方法包括将医疗装置植入患者体内，所述医疗装置包括衬底，衬底中的多个储存器，每个储存器中包含的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。 间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。 该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。 该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

    Methods for hermetically sealing microchip reservoir devices
    7.
    发明授权
    Methods for hermetically sealing microchip reservoir devices 有权
    密封微芯片储液装置的方法

    公开(公告)号：US06827250B2

    公开(公告)日：2004-12-07

    申请号：US10184259

    申请日：2002-06-28

    申请人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

    发明人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

    IPC分类号： B23K106

    CPC分类号： A61K9/0097

    摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.

    摘要翻译： 提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。 在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置 为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。

    Methods and devices for sealing microchip reservoir devices
    8.
    发明授权
    Methods and devices for sealing microchip reservoir devices 失效
    密封微芯片储存装置的方法和装置

    公开(公告)号：US06730072B2

    公开(公告)日：2004-05-04

    申请号：US09867976

    申请日：2001-05-30

    申请人： Rebecca S. Shawgo ,  Norman F. Sheppard, Jr. ,  Michael J. Cima ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Benjamin F. Polito ,  Scott A. Uhland

    发明人： Rebecca S. Shawgo ,  Norman F. Sheppard, Jr. ,  Michael J. Cima ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Benjamin F. Polito ,  Scott A. Uhland

    IPC分类号： A61K922

    CPC分类号： A61B5/145 ,  A61B5/03 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0097 ,  A61N1/303 ,  B01L3/50853 ,  B01L2300/0819

    摘要： Methods and devices are provided for mechanically sealing the reservoirs of microchip devices to prevent leakage from or between any of the reservoirs. In one embodiment, the method includes sandwiching a microchip device and a gasket material covering the reservoir openings between a front sealing frame and a backplate, such that the gasket material is compressed against the back side of the microchip device by the back plate. The front sealing frame is secured to the back sealing plate using fasteners or welding. The gasket material is preferably a flexible polymeric sheet, which is biocompatible and compatible with the reservoir contents. In another embodiment, a composite backplate is used in place of the back sealing plate and separate gasket material. The composite backplate can include a substrate having sealing plugs defined thereon. The composite backplate also can be designed to hold the drug, thereby combining the assembly steps of reservoir filling and sealing.

    摘要翻译： 提供了用于机械密封微芯片装置的储存器的方法和装置，以防止任何储存器之间的泄漏。 在一个实施例中，该方法包括在前密封框架和背板之间夹着微芯片装置和覆盖储存器开口的衬垫材料，使得衬垫材料通过后板压靠在微芯片装置的后侧。 前密封框架使用紧固件或焊接固定到后密封板。 垫片材料优选是柔性聚合物片材，其是生物相容性的并且与储存器内容物相容。 在另一个实施例中，使用复合背板来代替后密封板和单独的衬垫材料。 复合背板可以包括其上限定有密封塞的基板。 复合背板也可以设计成保持药物，从而结合储液器填充和密封的组装步骤。

    Device for controlling exposure of reservoir contents to surroundings
    9.
    发明授权
    Device for controlling exposure of reservoir contents to surroundings 有权
    用于控制水库内容物暴露于周围环境的装置

    公开(公告)号：US08016817B2

    公开(公告)日：2011-09-13

    申请号：US12348609

    申请日：2009-01-05

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott A. Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott A. Uhland

    IPC分类号： A61K9/22

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

    摘要翻译： 提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外界环境连通 储存器盖以使所述储存器盖发生相变和破裂。