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    Substituted N-glycosylamides, process for their preparation, and their use as medicaments
    4.
    发明授权
    Substituted N-glycosylamides, process for their preparation, and their use as medicaments 失效
    取代的N-甲酰胺，其制备方法及其作为药物的用途

    公开(公告)号：US5070190A

    公开(公告)日：1991-12-03

    申请号：US336497

    申请日：1989-04-12

    申请人： Oswald Lockhoff ,  John Goossens ,  Helmut Brunner ,  Michael Sperzel ,  Klaus G. Stunkel

    发明人： Oswald Lockhoff ,  John Goossens ,  Helmut Brunner ,  Michael Sperzel ,  Klaus G. Stunkel

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61P37/04 ,  C07H15/12

    CPC分类号： C07H15/12 ,  Y10S514/885

    摘要： The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andn represents 0 to 10,and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.

    摘要翻译： 本发明涉及通式Ⅰ“IMAGE”的新的N-糖基酰胺，其中R 1表示饱和的烷基或具有至多50个碳原子的单，双或三不饱和烯基，R2表示饱和的烷基或单 ，具有至多50个碳原子的双或三重不饱和烯基，A表示-CO-或代表其中R3表示氢，C1-C7烷基，羟甲基，1-羟乙基，巯基甲基，2-甲硫基乙基， 氨基丙基，2-脲基丙基，3-胍基丙基，4-氨基丁基，羧甲基，氨基甲酰基甲基，2-羧基乙基，2-氨基甲酰基乙基，苄基，4-羟基苄基，3-吲哚基甲基或4-咪唑基甲基，n表示0〜10， 在糖残基中用氨基酸残基取代，以及其制备方法及其作为药物的用途。