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    Hygroscopic treatment for degenerating discs
    1.
    发明申请
    Hygroscopic treatment for degenerating discs 审中-公开
    退化光盘的吸湿处理

    公开(公告)号：US20080097229A1

    公开(公告)日：2008-04-24

    申请号：US11511701

    申请日：2006-08-29

    申请人： Josee Roy ,  Susan J. Drapeau ,  Jeffrey C. Marx ,  Sean M. Haddock

    发明人： Josee Roy ,  Susan J. Drapeau ,  Jeffrey C. Marx ,  Sean M. Haddock

    IPC分类号： A61M31/00 ,  B65D69/00

    CPC分类号： A61L27/50 ,  A61F2002/30075 ,  A61F2002/444 ,  A61F2210/0061 ,  A61L27/14 ,  A61L2430/38

    摘要： Early treatment for a degenerated disc includes identifying a non-ruptured, dehydrated disc. A hygroscopic agent is then selected. This agent should pull water towards itself and have a hygroscopic compound with a molecular weight of at least 400 Daltons. Additionally, it may be desirable to selected hygroscopic compounds that are anionic or electrically neutral. The hygroscopic agent is then injected into the nucleus pulposus of the disc without any prior removal of the nucleus pulposus material. Because the surrounding disc structure allows for the passive diffusion of water into the nucleus pulposus, the hygroscopic agent will draw water into the nucleus pulposus, thus promoting tissue hydration within the disc. The hygroscopic agent may also include a biological agent and/or an imaging agent.

    摘要翻译： 退化椎间盘的早期治疗包括鉴定未破裂的脱水椎间盘。 然后选择吸湿剂。 该试剂应将水拉向自身并具有分子量至少为400道尔顿的吸湿性化合物。 另外，可能需要选择阴离子或电中性的吸湿化合物。 然后将吸湿剂注射到盘的髓核中，而无需先前去除髓核成分材料。 因为周围的圆盘结构允许水被钝化地扩散到髓核中，吸湿剂会将水吸入髓核，从而促进椎间盘内的组织水合作用。 吸湿剂还可以包括生物制剂和/或成像剂。

    Methods and compositions for the preservation of cells and tissues
    5.
    发明授权
    Methods and compositions for the preservation of cells and tissues 有权
    用于保存细胞和组织的方法和组合物

    公开(公告)号：US07960098B2

    公开(公告)日：2011-06-14

    申请号：US11777093

    申请日：2007-07-12

    申请人： Josee Roy ,  Susan J. Drapeau ,  Daniel A. Shimko

    发明人： Josee Roy ,  Susan J. Drapeau ,  Daniel A. Shimko

    IPC分类号： A01N1/00

    CPC分类号： A01N1/02 ,  A01N1/021

    摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.

    摘要翻译： 公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。 还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存​​，然后运输和 植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。

    Compositions and methods for treating cavity conditions
    7.
    发明申请
    Compositions and methods for treating cavity conditions 有权
    用于治疗腔状况的组合物和方法

    公开(公告)号：US20090035250A1

    公开(公告)日：2009-02-05

    申请号：US11890154

    申请日：2007-08-03

    申请人： Susan J. Drapeau ,  Josee Roy ,  Daniel Andrew Shimko

    发明人： Susan J. Drapeau ,  Josee Roy ,  Daniel Andrew Shimko

    IPC分类号： A61K31/74 ,  A61K33/06 ,  A61P43/00

    CPC分类号： A61K31/74 ,  A61K31/77 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

    摘要： Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts of at least one bioactive agent, such as magnesium compound, at least one lubricating agent, such as hyaluronic acid, and at least one cell membrane repairing agent, such as polyethylene glycol. The components of these compositions may be administered by a direct application, an application through a cannula, an intra-articular injection, as a flush fluid during an arthroscopy of the affected area, as a post-arthroscopy injection, or as part of a lavage of the area affected by the intra-articular pathology. In addition, the composition of the present invention may be administered to the patient from a pump or a depot.

    摘要翻译： 提供了用作润滑剂的组合物，方法和试剂盒以及用于治疗包括关节病理学在内的腔病理学。 组合物包含治疗有效量的至少一种生物活性剂，例如镁化合物，至少一种润滑剂，例如透明质酸，和至少一种细胞膜修复剂，例如聚乙二醇。 这些组合物的组分可以通过直接应用，通过插管施用，关节内注射，作为受影响区域的关节镜检查期间的冲洗液，作为关节内窥镜注射后或作为灌洗液的一部分施用 的受关节内病变影响的区域。 此外，本发明的组合物可以从泵或贮库给予患者。

    Methods and compositions for the preservation of cells and tissues
    8.
    发明授权
    Methods and compositions for the preservation of cells and tissues 有权
    用于保存细胞和组织的方法和组合物

    公开(公告)号：US08354221B2

    公开(公告)日：2013-01-15

    申请号：US13033908

    申请日：2011-02-24

    申请人： Josee Roy ,  Susan J. Drapeau ,  Daniel Andrew Shimko

    发明人： Josee Roy ,  Susan J. Drapeau ,  Daniel Andrew Shimko

    IPC分类号： A01N1/00

    CPC分类号： A01N1/02 ,  A01N1/021

    摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.

    摘要翻译： 公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。 还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存​​，然后运输和 植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。