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    Methods and systems for reducing complex conjugat ambiguity in interferometric data
    2.
    发明申请
    Methods and systems for reducing complex conjugat ambiguity in interferometric data 有权
    用于降低干涉测量数据中复杂的共轭模糊度的方法和系统

    公开(公告)号：US20060232783A1

    公开(公告)日：2006-10-19

    申请号：US11336652

    申请日：2006-01-20

    申请人： Michael Choma ,  Joseph Izatt ,  Anjul Davis

    发明人： Michael Choma ,  Joseph Izatt ,  Anjul Davis

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01B9/02004 ,  G01B9/02002 ,  G01B9/02069 ,  G01B9/02078 ,  G01B9/02091

    摘要： A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.

    摘要翻译： 在光学相干断层扫描（OCT）干涉图中可以解决复共轭模糊度。 参考光信号沿着参考路径传播。 样品光信号撞击样品反射器。 参考光信号相对于采样光信号被偏移，从而分离OCT干涉图的复共轭分量的正位移和负位移。

    Ophthalmic instruments, systems and methods especially adapted for conducting simultaneous tonometry and pachymetry measurements
    4.
    发明申请
    Ophthalmic instruments, systems and methods especially adapted for conducting simultaneous tonometry and pachymetry measurements 审中-公开
    眼科仪器，系统和方法，特别适用于进行同时眼压测量和深度测量

    公开(公告)号：US20070123768A1

    公开(公告)日：2007-05-31

    申请号：US11289639

    申请日：2005-11-30

    申请人： Sharon Freedman ,  Phillip McKinley ,  Pratap Challa ,  Leon Herndon ,  Cynthia Toth ,  Ronald Overaker ,  Brian Dodge ,  Brian Applegate ,  Joseph Izatt

    发明人： Sharon Freedman ,  Phillip McKinley ,  Pratap Challa ,  Leon Herndon ,  Cynthia Toth ,  Ronald Overaker ,  Brian Dodge ,  Brian Applegate ,  Joseph Izatt

    IPC分类号： A61B3/16 ,  A61B13/00

    CPC分类号： A61B3/16 ,  A61B3/1005

    摘要： Ophthalmic instruments, systems and methods enable tonometry and pachymetry measurements to be conducted simultaneously. As such, a patient's intraocular pressure (IOP) corrected for corneal thickness may be determined accurately by a single corneal applanation. Preferably, the ophthalmic instruments have a reference surface at a distal end of the instrument, an applanation plate spaced from the reference surface, and a compliant mount for mounting the applanation plate for resilient displacements relative to the reference surface. The instrument most preferably has a housing such that the reference surface is located at a fixed position at one end of the housing, and the applanation plate is mounted to that one end of the housing in coaxial spaced alignment relative to the reference surface by means of the compliant mount. If desired, the housing may have a handle and a substantially orthogonal head piece containing suitable optic mirrors which allow visible light to pass therethrough so that the procedure can be viewed and/or photographed.

    摘要翻译： 眼科仪器，系统和方法可以同时进行眼压测量和深度测量。 因此，可以通过单个角膜扁平度来准确地确定矫正角膜厚度的患者的眼内压（IOP）。 优选地，眼科器械具有在器械的远端处的参考表面，与参考表面间隔开的压平板，以及用于安装用于相对于参考表面的弹性位移的压平板的柔性安装件。 仪器最优选具有壳体，使得参考表面位于壳体的一端处的固定位置，并且压平板通过相对于参考表面以同轴间隔的对准方式安装到壳体的该一端，借助于 兼容安装。 如果需要，壳体可以具有手柄和基本上正交的头部件，其包含允许可见光通过的合适的光学镜，使得可以观看和/或拍摄该过程。

    INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY...
    5.
    发明申请
    INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY... 有权
    用于光学相干域反射测量的干涉仪

    公开(公告)号：US20070024868A1

    公开(公告)日：2007-02-01

    申请号：US11470079

    申请日：2006-09-05

    申请人： Joseph Izatt ,  Andrew Rollins

    发明人： Joseph Izatt ,  Andrew Rollins

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01B9/02091 ,  G01B9/02022 ,  G01B2290/35 ,  G01B2290/70 ,  G01N21/4795

    摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation-source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.

    摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到 光学检测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

    Method and apparatus for ultrasound imaging using acoustic impedance reconstruction
    6.
    发明授权
    Method and apparatus for ultrasound imaging using acoustic impedance reconstruction 失效
    使用声阻抗重建的超声成像方法和装置

    公开(公告)号：US06200266B1

    公开(公告)日：2001-03-13

    申请号：US09282215

    申请日：1999-03-31

    申请人： Nima Shokrollahi ,  William Tobocman ,  Sanford Roth ,  Joseph Izatt

    发明人： Nima Shokrollahi ,  William Tobocman ,  Sanford Roth ,  Joseph Izatt

    IPC分类号： A61B800

    CPC分类号： G01S7/52061 ,  A61B8/0858 ,  A61B8/13 ,  G01S7/52036 ,  G01S7/52046 ,  G01S7/52069 ,  G01S15/8993

    摘要： An ultrasound imaging system employs acoustic impedance reconstruction to produce high-resolution images of anatomical structures, which are virtually free of speckle. Determination of the acoustic impedance profile involves prefiltering of the incident ultrasound signal and the ultrasound signal reflected from the specimen to be imaged. A time domain window function is applied to both the incident and reflected signals, and an N-point FFT is computed for both the digitized incident and reflected signals to obtain the incident and reflected spectrums. A complex division of the reflected spectrum by the incident spectrum is performed to obtain the transfer function. A window function having a sharp, low-frequency cutoff is applied to the transfer function prior to performing an inverse FFT to obtain the estimated impulse response. The acoustic impedance of individual A-scans is calculated from the impulse response using the plane wave Born approximation, involving integration and exponentiation of the estimated impulse response. By mechanically or electronically scanning the transducer along a line, a series of A-scan acoustic impedance profiles are calculated and used to produce a two-dimensional, grey-scale B-scan image.

    摘要翻译： 超声成像系统采用声阻抗重建来产生解剖结构的高分辨率图像，其实质上不含斑点。 声阻抗曲线的确定涉及入射超声信号的预滤波和从待成像的样本反射的超声信号。 时域窗函数被应用于入射和反射信号，并且为数字入射和反射信号计算N点FFT以获得入射和反射光谱。 进行入射光谱的反射光谱的复分割以获得传递函数。 在执行逆FFT之前将具有尖锐的低频截止的窗函数应用于传递函数以获​​得估计的脉冲响应。 使用平面波Born近似从脉冲响应计算各个A扫描的声阻抗，涉及估计的脉冲响应的积分和取幂。 通过沿着一条线机械地或电子地扫描换能器，计算一系列A扫描声阻抗曲线并用于产生二维灰度B扫描图像。

    Methods, systems and computer program products for optical coherence tomography (OCT) using automatic dispersion compensation
    9.
    发明申请
    Methods, systems and computer program products for optical coherence tomography (OCT) using automatic dispersion compensation 有权
    用于光学相干断层扫描（OCT）的方法，系统和计算机程序产品，使用自动色散补偿

    公开(公告)号：US20070258094A1

    公开(公告)日：2007-11-08

    申请号：US11796399

    申请日：2007-04-27

    申请人： Joseph Izatt ,  Eric Buckland ,  William Brown

    发明人： Joseph Izatt ,  Eric Buckland ,  William Brown

    IPC分类号： G01J3/45 ,  G01B11/02 ,  G01B9/02

    CPC分类号： G01B9/02091 ,  G01B9/02044 ,  G01B9/02083 ,  G01N21/4795

    摘要： Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated. The acquired raw spectral data and the postulated trial spectral phase data are assembled into trial complex spectrum data. Trial A-scan data is computed by performing an inverse Fourier transform on the trial complex spectrum data and determining the magnitude of a result.

    摘要翻译： 提供了用于在光学相干断层扫描（OCT）系统中生成软件色散补偿参数的方法，系统和计算机程序产品。 对于样品上的给定横向位置和给定的参考反射，获取原始光谱干涉图数据。 假设对应于获取的光谱干涉图数据的每个波数样本的试验光谱相位。 将获得的原始光谱数据和假设的试验光谱相位数据组装成试验复数谱数据。 通过对试验复谱数据进行傅里叶逆变换并确定结果的大小来计算试验A-扫描数据。