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    INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY...
    2.
    发明申请
    INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY... 有权
    用于光学相干域反射测量的干涉仪

    公开(公告)号：US20070024868A1

    公开(公告)日：2007-02-01

    申请号：US11470079

    申请日：2006-09-05

    申请人： Joseph Izatt ,  Andrew Rollins

    发明人： Joseph Izatt ,  Andrew Rollins

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01B9/02091 ,  G01B9/02022 ,  G01B2290/35 ,  G01B2290/70 ,  G01N21/4795

    摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation-source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.

    摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到 光学检测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

    Optical imaging device
    3.
    发明授权
    Optical imaging device 有权
    光学成像装置

    公开(公告)号：US06615072B1

    公开(公告)日：2003-09-02

    申请号：US09315982

    申请日：1999-05-21

    申请人： Joseph A. Izatt ,  Michael V. Sivak ,  Andrew Rollins ,  Akihiro Horii ,  Tadashi Hirata ,  Shuhei Iizuka ,  Jiro Narita

    发明人： Joseph A. Izatt ,  Michael V. Sivak ,  Andrew Rollins ,  Akihiro Horii ,  Tadashi Hirata ,  Shuhei Iizuka ,  Jiro Narita

    IPC分类号： A61B600

    CPC分类号： A61B5/6852 ,  A61B5/0066 ,  G01B9/02002 ,  G01B9/0205 ,  G01B9/02061 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/65 ,  G01B2290/70

    摘要： An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.

    摘要翻译： 光学相干断层扫描（OCT）装置以低相干光照射生物组织，通过与来自组织的散射光的低相干干涉获得组织内部的高分辨率断层图像，并且设置有包括 光纤具有用于引入低相干光的柔性和薄的插入部分。 当光学探针插入血管或患者的体腔时，OCT使医生能够观察高分辨率的断层图像。 在光学探针中，通常根据光纤的弯曲发生双折射的波动，并且这种干涉对比度根据插入的条件而变化。 本发明的OCT在光学探针的发光侧设置有诸如法拉第旋转器的偏振补偿装置，使得OCT可以获得稳定的干涉输出，而不管弯曲的状态如何。

    Segmentation and quantification for intravascular optical coherence tomography images
    5.
    发明授权
    Segmentation and quantification for intravascular optical coherence tomography images 有权
    血管内光学相干断层扫描图像的分割和定量

    公开(公告)号：US08750615B2

    公开(公告)日：2014-06-10

    申请号：US13196845

    申请日：2011-08-02

    申请人： Andrew Rollins ,  David Wilson ,  Marco Costa ,  Hiram Bezerra ,  Zhao Wang

    发明人： Andrew Rollins ,  David Wilson ,  Marco Costa ,  Hiram Bezerra ,  Zhao Wang

    IPC分类号： G06K9/34 ,  G06K9/00

    CPC分类号： G06T7/0012 ,  A61B1/00009 ,  A61B1/3137 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/06 ,  G01B9/02091 ,  G06T7/12 ,  G06T7/62 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/20116 ,  G06T2207/20161 ,  G06T2207/30021 ,  G06T2207/30101

    摘要： A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.

    摘要翻译： 描述了用于血管结构和生理学的自动或半自动分割和定量的系统和相关方法，包括内腔，导丝，血管壁，钙化斑块，纤维帽，巨噬细胞，金属和生物可吸收支架的分割和定量，以及 包括结果的可视化。 钙化斑块分割可以用于估计浅层钙化的分布，并通知策略支架。 纤维帽的体积分割和定量可以提供斑块破裂背后机制的更全面的信息。 巨噬细胞的定量可以帮助诊断和预测不稳定斑块和相关的急性冠状动脉事件。 金属和生物可吸收支架的自动检测和定量可大大减少分析时间，便于及时决策干预措施。

    Gated optical coherence tomography (OCT) environmental chamber
    6.
    发明授权
    Gated optical coherence tomography (OCT) environmental chamber 有权
    门式光学相干断层扫描（OCT）环境室

    公开(公告)号：US08190244B2

    公开(公告)日：2012-05-29

    申请号：US12009992

    申请日：2008-01-23

    申请人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    发明人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    IPC分类号： A61B6/00

    CPC分类号： G01N21/4795 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7285

    摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.

    摘要翻译： 描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。 一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。 该方法还可以包括控制OCT装置以基于图像控制信号获取图像。 在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。 因此，该方法可以包括检测和控制一组可控环境因素。

    Gated optical coherence tomography (OCT)
    7.
    发明授权
    Gated optical coherence tomography (OCT) 有权
    门式光学相干断层扫描（OCT）

    公开(公告)号：US08812089B2

    公开(公告)日：2014-08-19

    申请号：US13481936

    申请日：2012-05-28

    申请人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    发明人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    IPC分类号： A61B6/00

    CPC分类号： G01N21/4795 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7285

    摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.

    摘要翻译： 描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。 一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。 该方法还可以包括控制OCT装置以基于图像控制信号获取图像。 在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。 因此，该方法可以包括检测和控制一组可控环境因素。

    Gated optical coherence tomography (OCT) environmental chamber
    8.
    发明申请
    Gated optical coherence tomography (OCT) environmental chamber 有权
    门式光学相干断层扫描（OCT）环境室

    公开(公告)号：US20080221445A1

    公开(公告)日：2008-09-11

    申请号：US12009992

    申请日：2008-01-23

    申请人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    发明人： Andrew Rollins ,  Michael Jenkins ,  Osman Chughtai

    IPC分类号： A61B5/05

    CPC分类号： G01N21/4795 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7285

    摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.

    摘要翻译： 描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。 一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。 该方法还可以包括控制OCT装置以基于图像控制信号获取图像。 在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。 因此，该方法可以包括检测和控制一组可控环境因素。

    SEGMENTATION AND QUANTIFICATION FOR INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES
    10.
    发明申请
    SEGMENTATION AND QUANTIFICATION FOR INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES 有权
    血管光学相干图像图像分割与定量

    公开(公告)号：US20120075638A1

    公开(公告)日：2012-03-29

    申请号：US13196845

    申请日：2011-08-02

    申请人： Andrew Rollins ,  David Wilson ,  Marco Costa ,  Hiram Bezerra ,  Zhao Wang

    发明人： Andrew Rollins ,  David Wilson ,  Marco Costa ,  Hiram Bezerra ,  Zhao Wang

    IPC分类号： G01B9/02 ,  G06K9/00

    CPC分类号： G06T7/0012 ,  A61B1/00009 ,  A61B1/3137 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/06 ,  G01B9/02091 ,  G06T7/12 ,  G06T7/62 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/20116 ,  G06T2207/20161 ,  G06T2207/30021 ,  G06T2207/30101

    摘要： A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.

    摘要翻译： 描述了用于血管结构和生理学的自动或半自动分割和定量的系统和相关方法，包括内腔，导丝，血管壁，钙化斑块，纤维帽，巨噬细胞，金属和生物可吸收支架的分割和定量，以及 包括结果的可视化。 钙化斑块分割可以用于估计浅层钙化的分布，并通知策略支架。 纤维帽的体积分割和定量可以提供斑块破裂背后机制的更全面的信息。 巨噬细胞的定量可以帮助诊断和预测不稳定斑块和相关的急性冠状动脉事件。 金属和生物可吸收支架的自动检测和定量可大大减少分析时间，便于及时决策干预措施。