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1.发明授权公开(公告)号：US08241842B2
公开(公告)日：2012-08-14
申请号：US11009901
申请日：2004-12-10
IPC分类号： C12Q1/00
CPC分类号： G01R33/56341
摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.
摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。
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公开(公告)号：US07633295B2
公开(公告)日：2009-12-15
申请号：US12109174
申请日：2008-04-24
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , G01R33/31 , G01R33/341 , G01R33/3815 , G01R33/385 , G01R33/4808 , G01R33/5604
摘要： A magnetic resonance (MR) microscope and a dual-mode optic and MR microscope system are disclosed. The MR microscope is provided with a horizontal stage above which a sample to be analyzed is located, a radiofrequency coil assembly located above the horizontal stage and below the sample, a magnetic field gradient module located under the horizontal stage, and a heat exchange unit thermally coupled to the magnetic field gradient module and located under the magnetic field gradient module. The dual-mode optic and MR microscope system is provided with an MR microscope and an optical microscope, the optical microscope comprising a mirror located above the sample.
摘要翻译： 公开了磁共振（MR）显微镜和双模光学和MR显微镜系统。 MR显微镜设置有水平台，在该水平台上，要分析的样品被定位，位于水平台上方和样品下方的射频线圈组件，位于水平台下方的磁场梯度模块和热交换单元 耦合到磁场梯度模块并位于磁场梯度模块下。 双模光学和MR显微镜系统设置有MR显微镜和光学显微镜，光学显微镜包括位于样品上方的反射镜。
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公开(公告)号：US20080284430A1
公开(公告)日：2008-11-20
申请号：US12109174
申请日：2008-04-24
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , G01R33/31 , G01R33/341 , G01R33/3815 , G01R33/385 , G01R33/4808 , G01R33/5604
摘要： A magnetic resonance (MR) microscope and a dual-mode optic and MR microscope system are disclosed, The MR microscope is provided with a horizontal stage above which a sample to be analyzed is located, a radiofrequency coil assembly located above the horizontal stage and below the sample, a magnetic field gradient module located under the horizontal stage, and a heat exchange unit thermally coupled to the magnetic field gradient module and located under the magnetic field gradient module. The dual-mode optic and MR microscope system is provided with an MR microscope and an optical microscope, the optical microscope comprising a mirror located above the sample
摘要翻译： 公开了一种磁共振（MR）显微镜和双模光学和MR显微镜系统。该MR显微镜具有水平平台，在该水平平台上，待分析的样品位于其上，位于水平平台及以下的射频线圈组件 样品，位于水平台下方的磁场梯度模块，以及热耦合到磁场梯度模块并位于磁场梯度模块下方的热交换单元。 双模光学和MR显微镜系统配备有MR显微镜和光学显微镜，光学显微镜包括位于样品上方的反射镜
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4.发明授权Dynamic motion contrast and transverse flow estimation using optical coherence tomography 有权使用光学相干断层扫描的动态运动对比度和横向流量估计公开(公告)号：US08369594B2
公开(公告)日：2013-02-05
申请号：US13179377
申请日：2011-07-08
CPC分类号： A61B5/0261 , A61B3/102 , A61B5/0066 , G01N21/4795 , G01N2021/1787
摘要： The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale motion of scatterers associated with Brownian motion and other non-flow motion. The inventive method of calculating motion contrast from the phase variance can differentiate regions of different mobility based on the motion contrast differences, and can use the phase information to characterize mobility properties of the scatterers. In flow regions, the inventive method for acquiring and analyzing motion contrast can identify the regions as well as characterize the motion. Furthermore, the inventive method can determine quantitative flow estimation, the index of refraction variations, and absorption variations within flow regions.
摘要翻译： 本文描述的方法是基于相位方差来确定光学相干断层摄影数据内的运动对比度的方法。 相位差对比度观察与布朗运动和其他非流动运动相关的散射体的纳米级运动。 从相位方差计算运动对比度的本发明方法可以基于运动对比差异来区分不同移动性的区域，并且可以使用相位信息来表征散射体的移动性质。 在流动区域中，用于获取和分析运动对比度的本发明的方法可以识别区域以及表征运动。 此外，本发明的方法可以确定流量区域中的定量流量估计，折射率变化指数和吸收变化。
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5.发明申请DYNAMIC MOTION CONTRAST AND TRANSVERSE FLOW ESTIMATION USING OPTICAL COHERENCE TOMOGRAPHY 有权动态运动对比度和横向流量估计使用光学相干计算公开(公告)号：US20120004562A1
公开(公告)日：2012-01-05
申请号：US13179377
申请日：2011-07-08
IPC分类号： A61B5/02
CPC分类号： A61B5/0261 , A61B3/102 , A61B5/0066 , G01N21/4795 , G01N2021/1787
摘要： The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale motion of scatterers associated with Brownian motion and other non-flow motion. The inventive method of calculating motion contrast from the phase variance can differentiate regions of different mobility based on the motion contrast differences, and can use the phase information to characterize mobility properties of the scatterers. In flow regions, the inventive method for acquiring and analyzing motion contrast can identify the regions as well as characterize the motion. Furthermore, the inventive method can determine quantitative flow estimation, the index of refraction variations, and absorption variations within flow regions.
摘要翻译： 本文描述的方法是基于相位方差来确定光学相干断层摄影数据内的运动对比度的方法。 相位差对比度观察与布朗运动和其他非流动运动相关的散射体的纳米级运动。 从相位方差计算运动对比度的本发明方法可以基于运动对比差异来区分不同移动性的区域，并且可以使用相位信息来表征散射体的移动性质。 在流动区域中，用于获取和分析运动对比度的本发明的方法可以识别区域以及表征运动。 此外，本发明的方法可以确定流量区域中的定量流量估计，折射率变化指数和吸收变化。
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6.发明授权Dynamic motion contrast and transverse flow estimation using optical coherence tomography 有权使用光学相干断层扫描的动态运动对比度和横向流量估计公开(公告)号：US07995814B2
公开(公告)日：2011-08-09
申请号：US11767187
申请日：2007-06-22
CPC分类号： A61B5/0261 , A61B3/102 , A61B5/0066 , G01N21/4795 , G01N2021/1787
摘要： The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale motion of scatterers associated with Brownian motion and other non-flow motion. The inventive method of calculating motion contrast from the phase variance can differentiate regions of different mobility based on the motion contrast differences, and can use the phase information to characterize mobility properties of the scatterers. In flow regions, the inventive method for acquiring and analyzing motion contrast can identify the regions as well as characterize the motion. Furthermore, the inventive method can determine quantitative flow estimation, the index of refraction variations, and absorption variations within flow regions.
摘要翻译： 本文描述的方法是基于相位方差来确定光学相干断层摄影数据内的运动对比度的方法。 相位差对比度观察与布朗运动和其他非流动运动相关的散射体的纳米级运动。 从相位方差计算运动对比度的本发明方法可以基于运动对比差异来区分不同移动性的区域，并且可以使用相位信息来表征散射体的移动性质。 在流动区域中，用于获取和分析运动对比度的本发明的方法可以识别区域以及表征运动。 此外，本发明的方法可以确定流量区域中的定量流量估计，折射率变化指数和吸收变化。
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7.发明授权公开(公告)号：US09116128B2
公开(公告)日：2015-08-25
申请号：US13346484
申请日：2012-01-09
IPC分类号： G01N33/547 , G01N33/553 , G01N33/543 , G01N21/77
CPC分类号： G01N21/7746 , G01N33/54353 , G01N2021/7789
摘要： Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
摘要翻译： 微腔谐振传感器具有使用点击化学功能化的外表面，例如涉及炔官能团和叠氮官能团的环加成反应。 第一聚合物连接元件与微腔的外表面结合并具有叠氮化物官能团，其结合环加成反应的结果与第二聚合物连接元素的炔官能团结合。 用于感测靶分子的功能化元件如抗体，抗原或蛋白质被结合到第二连接元件。
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公开(公告)号：US08507204B2
公开(公告)日：2013-08-13
申请号：US13363022
申请日：2012-01-31
申请人： Niles A. Pierce , Robert Dirks , Scott E. Fraser
发明人： Niles A. Pierce , Robert Dirks , Scott E. Fraser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6818 , C12Q1/6841 , Y10T436/143333 , C12Q2563/107 , C12Q2537/149 , C12Q2525/301
摘要： The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of interest and an initiator region that is able to initiate polymerization of nucleic acid monomers. After contacting a sample with the probe, labeled monomers are provided that form a tethered polymer. Triggered probes and self-quenching monomers can be used to provide active background suppression.
摘要翻译： 本发明涉及使用荧光标记的核酸探针来鉴定和成像生物样品中的分析物。 在优选的实施方案中，提供了包含能够特异性结合目标分析物的靶区域和能够引发核酸单体聚合的引发区域的探针。 在将样品与探针接触后，提供形成系留聚合物的标记单体。 触发的探针和自熄单体可用于提供活性背景抑制。
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公开(公告)号：US08329452B2
公开(公告)日：2012-12-11
申请号：US13183336
申请日：2011-07-14
IPC分类号： C12M1/34
CPC分类号： G01N29/036 , B82Y5/00 , B82Y35/00 , G01N33/54373 , G01N2291/0257
摘要： A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.
摘要翻译： 提供了一种生物功能化的纳米机电装置（BioNEMS），用于通过在绑定事件期间测量BioNEMS装置的机械位移的变化来感测溶液中的单分子。 根据本发明的生物功能化纳米机电装置通常包括纳米机械机械谐振器，与用于测量谐振器的机械位移的机械谐振器集成的检测器，以及连接到检测器的电子装置，用于将结果传达给用户。 还提供了一种生物功能化的纳米机电装置系统和利用本发明的生物功能化纳米机电装置的方法。
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公开(公告)号：US20120120398A1
公开(公告)日：2012-05-17
申请号：US13361076
申请日：2012-01-30
IPC分类号： G01N21/00
CPC分类号： G01N21/7746 , G01N21/783 , G01N33/0037 , G01N33/0047 , G01N33/0049 , G01N33/0054 , G01N33/22 , G01N2021/773 , G01N2021/7789 , Y02A50/245 , Y02A50/246 , Y02A50/25
摘要： Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or expands when it is exposed to or absorbs a gas or vapor, thereby changing the resonant wavelength of optical energy circulating within the micro-cavity/coating. Expansion or swelling of the coating may be reversible such that it contracts when gas or vapor diffuses from the coating. The coating deformation and/or a change of one or more optical properties of the optical energy circulating within the micro-cavity are used to detect the presence of the gas or vapor or molecules or particulates thereof
摘要翻译： 微腔气体或蒸气传感器以及气体或蒸气检测方法。 将光能引入具有可变形涂层如聚合物的共振微腔中。 当涂层暴露于或吸收气体或蒸气时，涂层膨胀或膨胀，从而改变在微腔/涂层内循环的光能的共振波长。 涂层的膨胀或膨胀可以是可逆的，使得当气体或蒸汽从涂层扩散时，其膨胀或膨胀。 使用在微腔内循环的光能的涂层变形和/或一种或多种光学特性的变化来检测气体或蒸汽或其分子或颗粒的存在
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