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    Methods and devices for measuring diffusion by magnetic resonance imaging
    1.
    发明授权
    Methods and devices for measuring diffusion by magnetic resonance imaging 有权
    用于通过磁共振成像测量扩散的方法和装置

    公开(公告)号：US08241842B2

    公开(公告)日：2012-08-14

    申请号：US11009901

    申请日：2004-12-10

    申请人： Julian Michael Tyszka ,  Changjun Yu ,  Daniel Schwartz ,  Ilene Sugino ,  Scott E. Fraser

    发明人： Julian Michael Tyszka ,  Changjun Yu ,  Daniel Schwartz ,  Ilene Sugino ,  Scott E. Fraser

    IPC分类号： C12Q1/00

    CPC分类号： G01R33/56341

    摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.

    摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。

    Methods and devices for measuring diffusion by magnetic resonance imaging
    2.
    发明申请
    Methods and devices for measuring diffusion by magnetic resonance imaging 有权
    用于通过磁共振成像测量扩散的方法和装置

    公开(公告)号：US20050163713A1

    公开(公告)日：2005-07-28

    申请号：US11009901

    申请日：2004-12-10

    申请人： Julian Tyszka ,  Changjun Yu ,  Daniel Schwartz ,  Ilene Sugino ,  Scott Fraser

    发明人： Julian Tyszka ,  Changjun Yu ,  Daniel Schwartz ,  Ilene Sugino ,  Scott Fraser

    IPC分类号： A61K49/00 ,  G01R33/563

    CPC分类号： G01R33/56341

    摘要： The present invention relates generally to the field of magnetic resonance imaging and, more particularly, to devices and methods used in the observation of the diffusion of molecules across a permeable membrane using magnetic resonance techniques. A typical embodiment of the invention is a method of observing the diffusion of a molecule in a container having a permeable membrane that is disposed between a first solution and a second solution in the container, by using magnetic resonance imaging to obtain an image of the diffusion of the molecule in the first solution across the membrane in to the second solution.

    摘要翻译： 本发明一般涉及磁共振成像领域，更具体地，涉及用于使用磁共振技术观察分子穿过可渗透膜扩散的装置和方法。 本发明的典型实施例是通过使用磁共振成像来观察分子在具有设置在容器中的第一溶液和第二溶液之间的渗透膜的容器中的扩散的方法，以获得扩散图像 的第一溶液中的分子穿过膜进入第二溶液。

    Soluble anion exchangers from hyperbranched macromolecules
    3.
    发明授权
    Soluble anion exchangers from hyperbranched macromolecules 有权
    来自超支化大分子的可溶性阴离子交换剂

    公开(公告)号：US08658702B2

    公开(公告)日：2014-02-25

    申请号：US12972423

    申请日：2010-12-17

    申请人： Mamadou Diallo ,  Changjun Yu

    发明人： Mamadou Diallo ,  Changjun Yu

    IPC分类号： C08F20/52

    CPC分类号： C08G73/0206 ,  B01J41/13 ,  C02F1/42 ,  C02F1/444 ,  C02F1/56 ,  C02F2001/422 ,  C02F2101/101 ,  C02F2101/12 ,  C02F2101/163 ,  C07C211/09 ,  C07C229/16 ,  C07C237/06 ,  C08G73/0226 ,  C08L79/02

    摘要： Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve their binding capacity or selectivity with particular water contaminants such as bromide, nitrate, and sulfate. The macromolecules may be either recyclable or non-recyclable, and may be recovered or separated from water using means such as ultrafiltration, flocculation, or immobilization on a substrate.

    摘要翻译： 用于从水和非水溶液中过滤污染物的新型大分子。 诸如聚乙烯亚胺（PEI）的分子可以被官能化，交联和/或季铵化以改善它们与特定水污染物如溴化物，硝酸盐和硫酸盐的结合能力或选择性。 大分子可以是可回收的或不可回收的，并且可以使用诸如超滤，絮凝或固定在基材上的方法从水中回收或分离。

    TREATMENT FOR EYE DISORDER
    5.
    发明申请
    TREATMENT FOR EYE DISORDER 有权
    治疗眼病

    公开(公告)号：US20080286255A1

    公开(公告)日：2008-11-20

    申请号：US12126100

    申请日：2008-05-23

    申请人： DANIEL M. SCHWARTZ ,  Scott Fraser ,  Robert H. Grubbs ,  Justin P. Gallivan ,  Changjun Yu

    发明人： DANIEL M. SCHWARTZ ,  Scott Fraser ,  Robert H. Grubbs ,  Justin P. Gallivan ,  Changjun Yu

    IPC分类号： A61K38/43 ,  A61P27/02

    CPC分类号： A61K49/0056 ,  A61K38/482 ,  A61K41/00 ,  A61K49/0017

    摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.

    摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，它涉及任何眼睛疾病的治疗，尽管在具体实施方案中个体具有增厚的布鲁赫氏膜。 使用活化能源来实现Bruch膜的受控扩散增强和/或降解，其能够改善脉络膜和视网膜之间的扩散转运。 给个体施用与膜相关的失活的扩散增强分子，然后将其精确地暴露于诸如光或超声的活化能源。