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11 条记录 (耗时 0.051 秒)

    Novel Monoclonal Anitbody and Use thereof
    1.
    发明申请
    Novel Monoclonal Anitbody and Use thereof 审中-公开
    新型单克隆抗体及其用途

    公开(公告)号：US20090263840A1

    公开(公告)日：2009-10-22

    申请号：US11992008

    申请日：2006-09-14

    申请人： Jun Hashimoto ,  Akihide Nampei ,  Wataru Ando ,  Tomofumi Kurokawa ,  Tsutomu Oshima

    发明人： Jun Hashimoto ,  Akihide Nampei ,  Wataru Ando ,  Tomofumi Kurokawa ,  Tsutomu Oshima

    IPC分类号： G01N33/53 ,  C07K16/00

    CPC分类号： C07K16/18 ,  C07K2317/34 ,  G01N33/6887 ,  G01N2800/10 ,  G01N2800/108

    摘要： The present invention provides an antibody capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-16F4.3 (FERM BP-10329), and an antibody of capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-12C9.2 (FERM BP-10328), and methods of risk prediction of bone fracture and/or diagnosis of osteoporosis by detecting a MEPE-derived molecule in a biological sample using the above-mentioned two kinds of antibodies.

    摘要翻译： 本发明提供能够特异性识别与小鼠单克隆抗体MAB-ME-16F4.3（FERM BP-10329）的抗原决定簇相同的氨基酸序列的抗体，以及能够特异性识别相同氨基酸序列的抗体 作为小鼠单克隆抗体MAB-ME-12C9.2（FERM BP-10328）的抗原决定簇，以及通过使用上述检测生物样品中的MEPE衍生的分子检测骨折和/或骨质疏松症诊断的风险预测方法 所述两种抗体。

    Electrophotographic photosensitive member, eletrophotographic apparatus and apparatus unit including the photosensitive member
    2.
    发明授权
    Electrophotographic photosensitive member, eletrophotographic apparatus and apparatus unit including the photosensitive member 失效
    电子照相感光构件，电子照相设备和包括感光构件的装置单元

    公开(公告)号：US5621130A

    公开(公告)日：1997-04-15

    申请号：US141630

    申请日：1993-10-27

    申请人： Wataru Ando ,  Takeshi Akasaka ,  Shigeru Nagase ,  Kaoru Kobayashi ,  Hajime Miyazaki

    发明人： Wataru Ando ,  Takeshi Akasaka ,  Shigeru Nagase ,  Kaoru Kobayashi ,  Hajime Miyazaki

    IPC分类号： B82B1/00 ,  G03G5/05 ,  G03G5/06 ,  C07F7/08 ,  C07F7/18

    CPC分类号： G03G5/062 ,  G03G5/0578 ,  G03G5/0605 ,  G03G5/0642

    摘要： A photosensitive member having stable electrophotographic characteristics can be constituted by an electroconductive support and a photosensitive layer disposed thereon and containing a novel fullerene compound having an organosilicon group as a charge-transporting substance. The fullerene compound may preferably have a polyhedral structure, particularly that of Buckminsterfullerene (C.sub.60) and be represented by the formula: C.sub.60 (A).sub.n . . . (2), wherein A denotes an organosilicon group represented by the formula: ##STR1## (wherein R.sub.1-1 and R.sub.1-2 independently denote a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted silyl group, a substituted or unsubstituted germyl group, a halogen atom, or a group constituting a substituted or unsubstituted ring by a mutual combination of R.sub.1-1 and R.sub.1-2 together with the Si atom in the formula); and n is an integer of 1 to 5, and a plurality of A in the case of n being two or larger can be the same or different with each other.

    摘要翻译： 具有稳定的电子照相特性的感光构件可由导电载体和设置在其上的感光层构成，并含有具有有机硅基团的新型富勒烯化合物作为电荷输送物质。 富勒烯化合物可以优选具有多面体结构，特别是Buckminsterfullerene（C60）的多面体结构，并由下式表示：C60（A）n。 。 。 （2）其中A表示由下式表示的有机硅基团：（1）（其中R1-1和R1-2独立地表示氢原子，取代或未取代的烷基，取代或未取代的芳基， 取代或未取代的烷氧基，取代或未取代的甲硅烷基，取代或未取代的锗基，卤素原子或构成取代或未取代的环的基团，通过R 1和R 2的相互组合与Si 原子在式中）; n为1〜5的整数，n为2以上的情况下的多个A可以相同或不同。

    Scaffold-free self-organized 3D synthetic tissue
    6.
    发明授权
    Scaffold-free self-organized 3D synthetic tissue 有权
    无支架的自组织3D合成组织

    公开(公告)号：US09370606B2

    公开(公告)日：2016-06-21

    申请号：US11676172

    申请日：2007-02-16

    申请人： Norimasa Nakamura ,  Hideki Yoshikawa ,  Wataru Ando

    发明人： Norimasa Nakamura ,  Hideki Yoshikawa ,  Wataru Ando

    IPC分类号： C12N5/00 ,  A61L27/36 ,  A61L27/38 ,  C07K14/78 ,  C12N5/077 ,  A61K35/12

    CPC分类号： A61L27/3633 ,  A61K35/12 ,  A61L27/3843 ,  C07K14/78 ,  C12N5/0655

    摘要： The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue. The present invention also provides a method for producing an implantable synthetic tissue which does not require a plurality of monolayer cell sheets assembled to form a three-dimensionally structured synthetic tissue. The present invention is characterized by richness in adhesion molecules, nonnecessity of additional fixation at an implantation site, and good biological integration.

    摘要翻译： 本发明可用于没有支架的实际植入手术。 本发明提供可通过培养产生并具有高水平分化能力的合成组织或复合物。 本发明还提供了使用替换和覆盖来修复和/或再生组织的治疗和药物。 通过在特定培养条件下培养细胞，使得培养基含有细胞外基质合成促进剂，细胞被组织并容易从培养皿中分离。 本发明是通过发现这种现象来实现的。 此外，可以通过以悬浮方式培养组织来调节组织的自收缩。 因此，可以调节组织的三维形状。 本发明还提供了一种用于生产可植入的合成组织的方法，其不需要组装成多个单层细胞片以形成三维结构的合成组织。 本发明的特征在于粘附分子的丰富性，植入部位的附加固定的不必要性以及良好的生物整合性。

    SCAFFOLD-FREE SELF-ORGANIZED 3D SYNTHETIC TISSUE
    7.
    发明申请
    SCAFFOLD-FREE SELF-ORGANIZED 3D SYNTHETIC TISSUE 有权
    无SCAFF自由组织的3D合成组织

    公开(公告)号：US20080004713A1

    公开(公告)日：2008-01-03

    申请号：US11676172

    申请日：2007-02-16

    申请人： Norimasa Nakamura ,  Hideki Yoshikawa ,  Wataru Ando

    发明人： Norimasa Nakamura ,  Hideki Yoshikawa ,  Wataru Ando

    IPC分类号： A61F2/02

    CPC分类号： A61L27/3633 ,  A61K35/12 ,  A61L27/3843 ,  C07K14/78 ,  C12N5/0655

    摘要： The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability. The present invention also provides a therapy and medicament for repairing and/or regenerating tissue using replacement and covering. By culturing cells under specific culture conditions such that medium contains an extracellular matrix synthesis promoting agent, the cells are organized and are easily detached from a culture dish. The present invention was achieved by finding such a phenomenon. In addition, the self contraction of the tissue can be regulated by culturing the tissue in a suspended manner. Therefore, it is possible to regulate the three-dimensional shape of the tissue. The present invention also provides a method for producing an implantable synthetic tissue which does not require a plurality of monolayer cell sheets assembled to form a three-dimensionally structured synthetic tissue. The present invention is characterized by richness in adhesion molecules, nonnecessity of additional fixation at an implantation site, and good biological integration.

    摘要翻译： 本发明可用于没有支架的实际植入手术。 本发明提供可通过培养产生并具有高水平分化能力的合成组织或复合物。 本发明还提供了使用替换和覆盖来修复和/或再生组织的治疗和药物。 通过在特定培养条件下培养细胞，使得培养基含有细胞外基质合成促进剂，细胞被组织并容易从培养皿中分离。 本发明是通过发现这种现象来实现的。 此外，可以通过以悬浮方式培养组织来调节组织的自收缩。 因此，可以调节组织的三维形状。 本发明还提供了一种用于生产可植入的合成组织的方法，其不需要组装成多个单层细胞片以形成三维结构的合成组织。 本发明的特征在于粘附分子的丰富性，植入部位的附加固定的不必要性以及良好的生物整合性。

    Method of producing N-formylamine
    8.
    发明授权
    Method of producing N-formylamine 失效
    生产N-甲酰胺的方法

    公开(公告)号：US4177121A

    公开(公告)日：1979-12-04

    申请号：US926717

    申请日：1978-07-21

    申请人： Wataru Ando ,  Kazuo Watanabe

    发明人： Wataru Ando ,  Kazuo Watanabe

    IPC分类号： C07D295/18 ,  C07C45/33 ,  C07C45/67 ,  C07C67/00 ,  C07C231/00 ,  C07C231/08 ,  C07C231/10 ,  C07C233/03 ,  C07D295/182 ,  B01J1/10

    CPC分类号： C07D295/182 ,  C07C45/33 ,  C07C45/673

    摘要： This invention provides a method of producing N-formylamine by photosensitized oxygenation of aldehyde-amine mixture. According to this invention, N-formylamine can be produced directly by photosensitized oxygenation of an aldehyde-amine mixture without separating intermediate enamine. In this invention, enamine is not used as a reactant, i.e. starting material, but a mixture of the aldehyde and amine is used as a reactant.

    摘要翻译： 本发明提供了通过醛 - 胺混合物的光敏氧合制备N-甲酰胺的方法。 根据本发明，N-甲酰胺可以直接通过醛 - 胺混合物的光敏氧合反应而不分离中间体烯胺。 在本发明中，烯胺不用作反应物，即起始原料，但醛和胺的混合物用作反应物。

    Electrophotographic photosensitive member, electrophotographic apparatus and apparatus unit including the photosensitive member
    9.
    发明授权
    Electrophotographic photosensitive member, electrophotographic apparatus and apparatus unit including the photosensitive member 失效

    公开(公告)号：US5622800A

    公开(公告)日：1997-04-22

    申请号：US528527

    申请日：1995-09-14

    申请人： Wataru Ando ,  Takeshi Akasaka ,  Hajime Miyazaki

    发明人： Wataru Ando ,  Takeshi Akasaka ,  Hajime Miyazaki

    IPC分类号： B82B1/00 ,  G03G5/05 ,  G03G5/06 ,  G03G5/047 ,  G03G5/09

    CPC分类号： G03G5/062 ,  G03G5/0578 ,  G03G5/0605 ,  G03G5/0642

    摘要： A photosensitive member having stable electrophotographic characteristics can be constituted by an electroconductive support and a photosensitive layer disposed thereon and containing a novel fullerene compound having an organosilicon group as a charge-transporting substance. The fullerene compound may preferably have a polyhedral structure, particularly that of Buckminsterfullerene (C.sub.60) and be represented by the formula: C.sub.60 (A).sub.n . . . (2), wherein A denotes an organosilicon group represented by the formula: ##STR1## (wherein R.sub.1-1 and R.sub.1-2 independently denote a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted silyl group, a substituted or unsubstituted germyl group, a halogen atom, or a group constituting a substituted or unsubstituted ring by a mutual combination of R.sub.1-1 and R.sub.1-2 together with the Si atom in the formula); and n is an integer of 1 to 5, and a plurality of A in the case of n being two or larger can be the same or different with each other.

    Method for forming a deposition film
    10.
    发明授权
    Method for forming a deposition film 失效
    沉积膜形成方法

    公开(公告)号：US4546008A

    公开(公告)日：1985-10-08

    申请号：US667816

    申请日：1984-11-02

    申请人： Keishi Saitoh ,  Wataru Ando

    发明人： Keishi Saitoh ,  Wataru Ando

    IPC分类号： B05D3/02 ,  B05D3/06 ,  B05D7/24 ,  C09D4/00 ,  C23C16/24 ,  G03G5/082

    CPC分类号： B05D1/60 ,  B05D1/62 ,  C09D4/00 ,  C23C16/24 ,  G03G5/08278 ,  B05D3/02 ,  B05D3/06

    摘要： A method for forming a deposition film comprises applying an excitation energy to a silane compound (SiOA) in a gaseous state having at least one substituent (OA) of the formula of --OC.sub.a H.sub.b X.sub.c where b+c=2a+1, a is a positive integer, b and c are zero or a positive integer, provided that b and c are not simultaneously zero and X is halogen atom to form a deposition film containing silicon atom on a substrate.A method for forming a deposition film comprises applying an excitation energy to a silane compound (SiA) in a gaseous state having 2-6 silicon atoms, having at least one substituent (A) of the formula of --C.sub.a H.sub.b X.sub.c where b+c=2a+1, a is a positive integer, b and c are zero or a positive integer, and X is halogen atom, containing at least one species selected from hydrogen atom and halogen atom, and further at least one of the silicon atoms present at the both ends bonding to only one species selected from hydrogen atom and halogen atom except for bonding to another silicon atom, to form a deposition film containing silicon atom on a substrate.

    摘要翻译： 一种用于形成沉积膜的方法包括向具有至少一个下式的-OCaHbXc的取代基（OA）的气态的硅烷化合物（SiOA）施加激发能，其中b + c = 2a + 1，a为正 如果b和c不是同时为零，而X是卤素原子以形成在衬底上含有硅原子的沉积膜，则整数，b和c为零或正整数。 形成沉积膜的方法包括向具有2-6个硅原子的气态的硅烷化合物（SiA）施加激发能，其具有至少一个下式的-CaHbXc的取代基（A），其中b + c = 2a +1，a为正整数，b和c为0或正整数，X为含有至少一个选自氢原子和卤素原子的卤原子，另外至少一个硅原子存在于 两端仅与一个选自氢原子和卤原子的物质结合，除了与另一个硅原子结合，以在基片上形成含有硅原子的沉积膜。