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    FLAVIVIRUS PROTEASE SUBSTRATES AND INHIBITORS
    1.
    发明申请
    FLAVIVIRUS PROTEASE SUBSTRATES AND INHIBITORS 审中-公开
    FLAVIVIRUS PROTEASE底物和抑制剂

    公开(公告)号：US20080032917A1

    公开(公告)日：2008-02-07

    申请号：US11619155

    申请日：2007-01-02

    申请人： Jun Li ,  Jennifer Harris ,  Christine Tumanut

    发明人： Jun Li ,  Jennifer Harris ,  Christine Tumanut

    IPC分类号： A61K38/00 ,  C07K2/00 ,  C07K5/00 ,  C07K7/00 ,  C12N5/00

    CPC分类号： C12Q1/37 ,  C12Q1/18 ,  G01N2333/18 ,  G01N2500/02

    摘要： The invention provides substrate specificity profiles for flaviviral proteases (e.g., dengue proteases or West Nile protease). Optimal flaviviral protease substrate sequences, both to the prime side and non-prime side of the flaviviral protease recognition site, are disclosed herein. The flaviviral protease substrate sequences are used in designing substrates, inhibitors, and prodrugs. Flaviviral protease inhibitors based on substrate specificity are also provided.

    摘要翻译： 本发明提供黄病毒蛋白酶（例如登革热蛋白酶或西尼罗河蛋白酶）的底物特异性谱。 本文公开了黄病毒蛋白酶识别位点的最优侧和非质量侧的最佳黄病毒蛋白酶底物序列。 黄病毒蛋白酶底物序列用于设计底物，抑制剂和前药。 还提供了基于底物特异性的黄病毒蛋白酶抑制剂。

    Wooden baby walker
    2.
    外观设计
    Wooden baby walker 有权

    公开(公告)号：USD1013584S1

    公开(公告)日：2024-02-06

    申请号：US29911666

    申请日：2023-09-07

    申请人： Jun Li

    设计人： Jun Li

    摘要： FIG. 1 is a front, right and top perspective view of a wooden baby walker, showing my new design;
    FIG. 2 is a rear, left and bottom perspective view thereof;
    FIG. 3 is a front view thereof;
    FIG. 4 is a rear view thereof;
    FIG. 5 is a left side view thereof;
    FIG. 6 is a right side view thereof;
    FIG. 7 is a top plan view thereof; and,
    FIG. 8 is a bottom plan view thereof.
    The broken lines shown in the drawings illustrate portions of the wooden baby walker that form no part of the claimed design.

    Toy tool box
    3.
    外观设计
    Toy tool box 有权

    公开(公告)号：USD1001203S1

    公开(公告)日：2023-10-10

    申请号：US29876217

    申请日：2023-05-18

    申请人： Jun Li

    设计人： Jun Li

    摘要： FIG. 1 is a front, left and bottom perspective view of a toy tool box, showing my new design;
    FIG. 2 is a front, left and bottom perspective view thereof, in an alternate position;
    FIG. 3 is a front view thereof;
    FIG. 4 is a rear view thereof;
    FIG. 5 is a left side view thereof;
    FIG. 6 is a right side view thereof;
    FIG. 7 is a top plan view thereof; and,
    FIG. 8 is a bottom plan view thereof.
    The pattern shown on the surfaces of the toy tool box illustrates a wood grain appearance that is continuous throughout the surfaces on which it is shown.
    The shaded portions of the design are included to illustrate the color black.

    Contour gauge
    4.
    外观设计
    Contour gauge 有权

    公开(公告)号：USD944666S1

    公开(公告)日：2022-03-01

    申请号：US29777553

    申请日：2021-04-07

    申请人： Jun Li

    设计人： Jun Li

    Method for semantics based trick mode play in video system
    8.
    发明授权
    Method for semantics based trick mode play in video system 有权
    视频系统中基于语义的特技模式播放方法

    公开(公告)号：US09438876B2

    公开(公告)日：2016-09-06

    申请号：US13824344

    申请日：2010-09-17

    申请人： Jun Li ,  Xiaojun Ma ,  Jun Xu

    发明人： Jun Li ,  Xiaojun Ma ,  Jun Xu

    IPC分类号： H04N9/80 ,  G11B27/00 ,  G11B27/28 ,  H04N5/783

    CPC分类号： H04N9/80 ,  G11B27/005 ,  G11B27/28 ,  H04N5/783

    摘要： Trick mode play for controlling video content playback can be realized using a semantic based criterion in order to achieve a more uniform playback experience for the viewer, when that viewer wishes to observe the video content presented according to a selected semantic. In one embodiment of the method, semantics associated with shorter time intervals in the video content are replayed in trick mode play proportionally slower than semantics associated with longer time intervals, wherein the proportionally is determined, at least in part, to the time interval associated with each semantic. In various embodiments, semantics can include scenes, audio, metadata, tags, and the like. The semantics based trick mode play approach allows for a more uniform viewing experience, on a time duration basis, from one semantic to the next.

    摘要翻译： 可以使用基于语义的标准来实现用于控制视频内容回放的模式播放，以便当观众希望观察根据所选语义呈现的视频内容时，为观众提供更均匀的播放体验。 在该方法的一个实施例中，与特征模式播放相关联的与视频内容中较短时间间隔相关联的语义比与较长时间间隔相关联的语义成比例地慢，其中，至少部分地至少部分地确定与 每个语义。 在各种实施例中，语义可以包括场景，音频，元数据，标签等。 基于语义的特技模式播放方法允许在时间基础上从一个语义到另一个语义的更均匀的观看体验。

    Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels
    9.
    发明授权
    Compositions and methods for modulating cell-cell fusion via intermediate-conductance calcium-activated potassium channels 有权
    通过中间电导钙激活钾通道调节细胞融合的组合物和方法

    公开(公告)号：US09428568B2

    公开(公告)日：2016-08-30

    申请号：US13128290

    申请日：2009-11-10

    申请人： Jun Li ,  Agnès Vignery

    发明人： Jun Li ,  Agnès Vignery

    IPC分类号： G01N33/53 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of intermediate-conductance calcium-activated potassium (SK4) channel. In some embodiments, the compositions and methods of the invention provide for inhibition of multi-nucleated osteoclastogenesis and cell-cell fusion, especially cell fusion involving macrophages. In such embodiments, the compositions can comprise inhibitory nucleic acids, monoclonal antibodies or small molecule inhibitors of the SK4 channels and find use in preventing and/or treating various diseases or disorders including bone loss, autoimmune and inflammatory diseases or disorders, implant and transplant rejection, and cancer metastasis. In other embodiments, the compositions and methods of the invention provide for activation of cell-cell fusion. Also provided are methods to screen for SK4 channel modulators (inhibitors or activators) that modulate cell-cell fusion, particularly macrophage cell fusion.

    摘要翻译： 提供了通过使用调节中间电导钙激活钾（SK4）通道的表达，活性或功能的试剂来调节细胞 - 细胞融合的组合物和方法。 在一些实施方案中，本发明的组合物和方法提供了抑制多核破骨细胞发生和细胞 - 细胞融合，特别是涉及巨噬细胞的细胞融合。 在这样的实施方案中，组合物可以包含SK4通道的抑制性核酸，单克隆抗体或小分子抑制剂，并且可用于预防和/或治疗各种疾病或病症，包括骨丢失，自身免疫和炎性疾病或病症，植入物和移植排斥 ，和癌转移。 在其它实施方案中，本发明的组合物和方法提供细胞 - 细胞融合的活化。 还提供了筛选调节细胞融合，特别是巨噬细胞融合的SK4通道调节剂（抑制剂或活化剂）的方法。

    Access procedures for in-device coexistence interference avoidance
    10.
    发明授权
    Access procedures for in-device coexistence interference avoidance 有权
    设备间共存干扰避免的访问过程

    公开(公告)号：US09419740B2

    公开(公告)日：2016-08-16

    申请号：US13289695

    申请日：2011-11-04

    申请人： Changhoi Koo ,  Jun Li ,  Zhijun Cai

    发明人： Changhoi Koo ,  Jun Li ,  Zhijun Cai

    IPC分类号： H04W4/00 ,  H04J11/00 ,  H04W88/06 ,  H04W74/00

    CPC分类号： H04J11/0023 ,  H04W74/004 ,  H04W88/06

    摘要： A method, system and device are provided for avoiding in-device coexistence interference between different radio technologies by allocating random access channel preambles to include one or more dedicated access preambles to be sued for sending IDC interference indication messages over a random access channel (RACH) to a radio access network. In response, the radio network provides control parameters and/or instructions for avoiding interference in a random access response message corresponding to the IDC interference indication message using one or more fields in the MAC subheader and payload fields of a designated IDC MAC PDU message.

    摘要翻译： 提供了一种方法，系统和设备，用于通过分配随机接入信道前导码来包括一个或多个专用接入前导码，用于通过随机接入信道（RACH）发送IDC干扰指示消息来避免不同无线电技术之间的设备间共存干扰， 到无线电接入网络。 作为响应，无线电网络提供用于使用指定的IDC MAC PDU消息的MAC子头和有效载荷字段中的一个或多个字段来避免对与IDC干扰指示消息相对应的随机接入响应消息中的干扰的控制参数和/或指令。