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    Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient
    1.
    发明授权
    Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient 失效
    链霉菌sp产生抗菌素和免疫抑制剂，其包含作为活性成分的抗菌素

    公开(公告)号：US06608045B2

    公开(公告)日：2003-08-19

    申请号：US09308482

    申请日：1999-05-17

    申请人： Hyoung Sik Chun ,  Jong Gwan Kim ,  Hung Bae Chang ,  Seung Kee Moon ,  Hyeog Jin Son ,  Chung Il Hong ,  Jung Woo Kim ,  Nam Hyun Lyu

    发明人： Hyoung Sik Chun ,  Jong Gwan Kim ,  Hung Bae Chang ,  Seung Kee Moon ,  Hyeog Jin Son ,  Chung Il Hong ,  Jung Woo Kim ,  Nam Hyun Lyu

    IPC分类号： C12P1702

    CPC分类号： C12R1/465 ,  C12P7/22

    摘要： The present invention relates to Streptomyces sp. producing tautomycetin which possesses an immunosuppressive or antibacterial activities, a process for preparing tautomycetin from the said microorganism, and an immunosuppressant or immunosuppressive pharmaceutical composition comprising tautomycetin as an active ingredient which suppresses interleukin-2 production, CD69 and interleukin-2 receptor(IL-2R) expression on the cell surface, and graft rejection in the organ transplantation. The present inventors isolated a soil microorganism which produces a substance possessing antibiotic and immunosuppressive activities, and identified the said microorganism and substance as a novel Streptomyces sp. and tautomycetin, respectively. Further, the present inventors developed a method of manufacturing the tautomycetin in a large scale from the culture of the said microorganism and discovered that tautomycetin suppresses mouse mixed lymphocyte reaction(MLR) and the expression of IL-2 based on a series of experiments employing cell line transfected with a recombinant gene.

    摘要翻译： 本发明涉及链霉菌属（Streptomyces sp。） 产生具有免疫抑制或抗菌活性的抗菌素，用于从所述微生物制备抗菌素的方法，以及包含抑制白细胞介素2产生的活性成分的免疫抑制剂或免疫抑制剂或免疫抑制药物组合物，CD69和白细胞介素-2受体（IL-2R ）在细胞表面的表达，以及器官移植中的移植排斥反应。 本发明人分离出产生具有抗生素和免疫抑制活性的物质的土壤微生物，并将所述微生物和物质鉴定为新型链霉菌属（Streptomyces sp。）。 和tautomycetin。 此外，本发明人开发了从所述微生物的培养物大规模制造肠胃菌素的方法，并且发现根据使用细胞的一系列实验，互连霉素抑制小鼠混合淋巴细胞反应（MLR）和IL-2的表达 用重组基因转染。

    ELECTROCHROMIC DEVICE
    5.
    发明申请
    ELECTROCHROMIC DEVICE 有权
    电致发光器件

    公开(公告)号：US20130033735A1

    公开(公告)日：2013-02-07

    申请号：US13396247

    申请日：2012-02-14

    申请人： Chang Ho Noh ,  Rupasree Ragini Das ,  Jung Woo Kim ,  Seog Jin Jeon

    发明人： Chang Ho Noh ,  Rupasree Ragini Das ,  Jung Woo Kim ,  Seog Jin Jeon

    IPC分类号： G02F1/157 ,  G02F1/15

    CPC分类号： G02F1/15 ,  G02F1/163 ,  G02F2001/134345 ,  G02F2001/1512 ,  G02F2202/02 ,  G02F2203/34

    摘要： According to example embodiments, an electrochromic device includes pixel containing a first sub-pixel and a second sub-pixel. The first sub-pixel includes a first electrolyte contacting a first electrochromic layer. The first electrochromic layer includes a first electrochromic material configured to display each one of transparency and at least two colors, based on a voltage applied to the first electrochromic material. The second sub-pixel includes a second electrolyte contacting a second electrochromic layer. The second electrochromic layer includes a second electrochromic material configured to display each one of transparency, black, and at least one color other than black, based on a voltage applied to the second electrochromic material.

    摘要翻译： 根据示例性实施例，电致变色器件包括包含第一子像素和第二子像素的像素。 第一子像素包括与第一电致变色层接触的第一电解质。 第一电致变色层包括第一电致变色材料，其被配置为基于施加到第一电致变色材料的电压来显示透明度和至少两种颜色的每一种。 第二子像素包括与第二电致变色层接触的第二电解质。 第二电致变色层包括第二电致变色材料，其被配置为基于施加到第二电致变色材料的电压来显示透明度，黑色和除了黑色之外的至少一种颜色的每一种。

    Polymerized toner having high resolution
    6.
    发明申请
    Polymerized toner having high resolution 审中-公开
    具有高分辨率的聚合调色剂

    公开(公告)号：US20100104968A1

    公开(公告)日：2010-04-29

    申请号：US12588693

    申请日：2009-10-23

    申请人： Dong Jin Park ,  Chang Soon Lee ,  Wook Jang ,  Yu Na Kim ,  Jung Woo Kim

    发明人： Dong Jin Park ,  Chang Soon Lee ,  Wook Jang ,  Yu Na Kim ,  Jung Woo Kim

    IPC分类号： G03G9/093 ,  G03G9/09 ,  G03G9/08 ,  G03G9/087

    CPC分类号： G03G9/0806 ,  G03G9/08704 ,  G03G9/08706 ,  G03G9/08728 ,  G03G9/08786 ,  G03G9/08791

    摘要： A polymerized toner is provided. The polymerized toner comprises a reactive anionic surfactant having at least one reactive functional group. The reactive anionic surfactant is added simultaneously with a dispersant to prepare an aqueous dispersion or is added within 2 hour after a polymerization reaction of a monomer mixture is initiated in an aqueous dispersion. This simultaneous or rapid addition allows the reactive anionic surfactant to be dispersed on the surface of the toner particles. The reactive anionic surfactant is located over the entire surface of the toner particles to increase the surface charge density of the toner, achieving good charge stability and excellent imaging characteristics.

    摘要翻译： 提供聚合调色剂。 聚合的调色剂包含具有至少一个反应性官能团的反应性阴离子表面活性剂。 将反应性阴离子表面活性剂与分散剂同时加入以制备水分散体，或者在单体混合物在水分散体中开始聚合反应后2小时内加入。 这种同时或快速的添加允许反应性阴离子表面活性剂分散在调色剂颗粒的表面上。 反应性阴离子表面活性剂位于调色剂颗粒的整个表面上，以增加调色剂的表面电荷密度，实现良好的电荷稳定性和优异的成像特性。

    Method for Manufacturing Toner
    7.
    发明申请
    Method for Manufacturing Toner 审中-公开
    制造调色剂的方法

    公开(公告)号：US20090280430A1

    公开(公告)日：2009-11-12

    申请号：US12226065

    申请日：2008-01-30

    申请人： Hui Je Lee ,  Woo Cheul Jung ,  Ji Hoon Lee ,  Yu Na Kim ,  Jung Woo Kim

    发明人： Hui Je Lee ,  Woo Cheul Jung ,  Ji Hoon Lee ,  Yu Na Kim ,  Jung Woo Kim

    IPC分类号： G03G9/087 ,  G03G9/08

    CPC分类号： G03G9/0804 ,  G03G9/0806 ,  G03G9/08702 ,  G03G9/08782 ,  G03G9/09741 ,  G03G9/09766 ,  G03G9/09775 ,  G03G9/09783 ,  G03G9/09791

    摘要： There is provided a method for manufacturing a toner capable of providing a toner having excellent low-temperature fixing property and anti-offset property by adjusting a molecular weight distribution of a polymerization toner to a narrow distribution range. The method is characterized in that a toner is polymerized using a reversible addition-fragmentation chain transfer polymerization (RAFT) method by adding a dithioacetate, xanthate or dithioester-based chain transfer agent in the polymerization of a toner. The method for manufacturing a toner comprises: dissolving a dispersant in water to prepare an aqueous dispersion solution; mixing a binder resin monomer, a charge control agent, a pigment, a wax and a dithioacetate, xanthate or dithioester-based chain transfer agent to prepare a monomer mixture; adding the monomer mixture to the aqueous dispersion solution and suspension-polymerizing the monomer mixture to form a toner composition; removing the dispersant from the toner composition; and drying the dispersant-free toner composition under a vacuum condition.

    摘要翻译： 提供了一种制造调色剂的方法，该调色剂能够通过将聚合调色剂的分子量分布调节到窄的分布范围来提供具有优异的低温定影性和抗偏移性的调色剂。 该方法的特征在于，通过在调色剂的聚合中加入二硫代乙酸酯，黄原酸酯或二硫代酯类的链转移剂，使用可逆的加成 - 断裂链转移聚合（RAFT）方法使调色剂聚合。 调色剂的制造方法包括：将分散剂溶解在水中以制备水分散液; 混合粘合剂树脂单体，电荷控制剂，颜料，蜡和二硫代乙酸酯，黄原酸酯或二硫代酯基链转移剂以制备单体混合物; 将单体混合物加入到水分散液中，并使单体混合物悬浮聚合以形成调色剂组合物; 从调色剂组合物中除去分散剂; 并在真空条件下干燥无分散剂的调色剂组合物。