摘要:
This invention provides a process for producing 3'-deoxy-'-fluorothymidine, which comprises allowing 3'-deoxy-'-fluoro-5'-mesylthymidine (the stating material) to react with an acetylating agent, selected from the group consisting of alkali metal salts of acetic acid, amine salts of acetic acid and ammonium acetate, in an aprotic, ploar solvent to form the 5'-acetyl derivative, and ammonium acetate, in an aprotic, polar solvent to form the 5'-acetyl derivative, and eliminating the 5'-acetyl group from this intermediate, thereby giving the objective 3'-deoxy-'-fluorothymidine.According to the process of this invention described above, the 5'-mesyl derivative can be efficiently acetylated, and 3'-deoxy-'-fluorotymidine can be obtained in a high yield.
摘要:
The instant invention is drawn to a method for manufacturing 2',3'-dideoxy-2',3'-didehydronucleoside compounds by reacting a ribonucleoside derivative wherein the hydroxyl in the 5'-position of the furanose ring of said ribonucleoside is protected by a silyl protective group, with an acid anhydride such as acetic anhydride in the presence of a catalyst such as hydrous zirconium oxide, and then subjecting the reaction product to decarboxylation. The decarboxylation can be effected by heating the reaction product. This method can be performed in a single step, and requires no reagents which are expensive or chemicals which should be handled with care. Hence, it serves to manufacture 2',3'-dideoxy-2',3'-didehydronucleosides easily at low cost.
摘要:
A solution monitoring system is provided for gathering, filtering, and analyzing information associated with solutions for managing monitoring, upgrades, and migrations. Telemetry may be recorded for various types of solution events and various properties of solutions as part of an add-in intelligence. Furthermore, add-in management tools are provided for administrators and end users.
摘要:
Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.
摘要:
A wire winding device which uses a large-sized supply bobbin, which has a large capacity and a large diameter, to highly precisely suppress a variation in tension which variation occurs when a coil is formed by winding a wire material at high speed with the wire material aligned with a winding frame. Rotation (the number of rotation, and timing) of the supply bobbin relative to rotation of the coil is controlled based on the difference between the amount of take-up of the wire material taken up on the winding frame side and the amount of pay-out of the wire material paid out from the supply bobbin, and the control is performed such that the amount of the take-up and the amount of the pay-out agree with each other every moment. This can highly precisely suppress a variation in tension even if there are large differences between inertia of and the diameters of the coil and the supply bobbin.
摘要:
A sensing element lead wire connecting structure is provided for stably connecting conductors, forming the coil of a sensing element for load measurement, with the lead wires for external connection. In the sensing element lead wire connecting structure, a flexible circuit board is fixed to a base member receiving an applied load to be measured. Conductive patterns are formed on the circuit board and are electrically connected to the lead wires for externally outputting the load measurement.
摘要:
A solution monitoring system is provided for gathering, filtering, and analyzing information associated with solutions for managing monitoring, upgrades, and migrations. Telemetry may be recorded for various types of solution events and various properties of solutions as part of an add-in intelligence. Furthermore, add-in management tools are provided for administrators and end users.
摘要:
The tricyclic benzazepine and benzothiazepine derivatives represented by the formula (I) and pharmacologically acceptable salts thereof are disclosed. ##STR1## wherein Z represents CO, --CR.sup.6 R.sup.7 -- or --S(O).sub.n, R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl. These compounds have anti-allergic effect and are useful for the treatment and prophylaxis of allergic diseases.
摘要:
A wire winding device which uses a large-sized supply bobbin, which has a large capacity and a large diameter, to highly precisely suppress a variation in tension which variation occurs when a coil is formed by winding a wire material at high speed with the wire material aligned with a winding frame. Rotation (the number of rotation, and timing) of the supply bobbin relative to rotation of the coil is controlled based on the difference between the amount of take-up of the wire material taken up on the winding frame side and the amount of pay-out of the wire material paid out from the supply bobbin, and the control is performed such that the amount of the take-up and the amount of the pay-out agree with each other every moment. This can highly precisely suppress a variation in tension even if there are large differences between inertia of and the diameters of the coil and the supply bobbin.
摘要:
A finely structured grooved gate transistor of which the threshold voltage does not decrease in spite of the small size and of which the threshold voltage of the transistor can be adjusted by shape. The shape of a groove corner of the transistor as a semiconductor device is contained in a concentric circle having a radius of curvature r.+-.L/5 (L: channel length) and the radius of curvature r, i.e., the geometric parameter has a relationship with the doping concentration as shown in FIG. 1B. Alternatively, the average (a+b)/2 (geometric parameter) of the sum of the two sides opposite the right angle of a right triangle formed of a straight line in contact with the gate bottom in parallel to the substrate surface of a grooved gate transistor, a perpendicular line to the substrate bottom surface from the source and drain ends at a portion formed with a channel and a straight line in contact with the groove corner has a relationship with the doping concentration as shown in FIG. 1B. The threshold voltage is not reduced even when the channel length is decreased by adjusting the groove shape and the doping concentration.