公开(公告)号：US20130217115A1

公开(公告)日：2013-08-22

申请号：US13880373

申请日：2011-10-18

申请人： Junpu Xu ,  Zhao Chen ,  Minli Mo ,  Jun Li

发明人： Junpu Xu ,  Zhao Chen ,  Minli Mo ,  Jun Li

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q1/6851 ,  C12Q2545/101

摘要： Disclosed is a plasmid standard for use in fluorescent quantitative PCR assays. More specifically, the present invention provides a plasmid standard as well as amplification primers and detection probes thereof for use in the detection of gene mutation and expression amount.

摘要翻译： 公开了用于荧光定量PCR测定的质粒标准品。 更具体地，本发明提供了用于检测基因突变和表达量的质粒标准品以及扩增引物及其检测探针。

公开(公告)号：US20130095491A1

公开(公告)日：2013-04-18

申请号：US13581008

申请日：2011-02-22

申请人： Junpu Xu ,  Zhao Chen ,  Jun Li

发明人： Junpu Xu ,  Zhao Chen ,  Jun Li

IPC分类号： G01N21/76 ,  C12N15/63

CPC分类号： C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/106 ,  G01N2021/6432

摘要： The present invention relates to a method and assay kit for BRAF gene mutations which relates to the effect of molecule-targeting anti-tumor drug. Particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of BRAF gene, together with the use thereof. The present invention detects the mutations at specific sites of BRAF gene, and can predict the therapeutic efficacy of anti-EGFR tyrosine kinase inhibitors, an anti-tumor drug. Therefore, the present invention can provide a guidance to individualized treatments for cancer patients.

摘要翻译： 本发明涉及涉及分子靶向抗肿瘤药物的作用的BRAF基因突变的方法和测定试剂盒。 特别地，本发明涉及用于检测BRAF基因热点突变的荧光定量PCR方法及试剂盒及其用途。 本发明检测BRAF基因特异位点的突变，可以预测抗EGFR酪氨酸激酶抑制剂抗肿瘤药物的疗效。 因此，本发明可以为癌症患者的个体化治疗提供指导。

公开(公告)号：US10385404B2

公开(公告)日：2019-08-20

申请号：US15314952

申请日：2015-05-27

申请人： JIAXING ACCB DIAGNOSTICS LTD. ,  Minli Mo ,  Hui Li ,  Zhao Chen ,  Feng Ding ,  Jun Li

发明人： Minli Mo ,  Hui Li ,  Zhao Chen ,  Feng Ding ,  Jun Li

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/6886 ,  C12Q1/68 ,  C12Q1/6848 ,  C12Q1/6858

摘要： This invention relates to a kit for detecting NRAS gene mutation, and this kit can be used to detect cancer-related NRAS gene mutation. The said kit comprises: (1) the internal reference detection reagent, which includes the internal reference gene specific primers, internal reference gene specific probes and dNTP solution; (2) the NRAS mutation detection reagent, which includes the NRAS gene mutant type specific primers, NRAS gene mutant type specific probes, internal control gene specific primers, internal control gene specific probes and dNTP solution; (3) the Taq DNA polymerase; and (4) the NRAS positive quality control.

公开(公告)号：US20120237935A1

公开(公告)日：2012-09-20

申请号：US13497527

申请日：2010-09-20

申请人： Junpu XU ,  Zhao Chen ,  Jun Li

发明人： Junpu XU ,  Zhao Chen ,  Jun Li

IPC分类号： G01N21/64 ,  C12N15/63

CPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/156

摘要： The present invention relates to a detection method and a detection kit for EGFR gene mutations, which relates to the therapeutic efficacy of molecular-targeted anti-cancer drugs. Particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of EGFR gene, together with the use thereof. The present invention detects the mutations at specific sites of EGFR gene, and can predict the therapeutic efficacy of EGFR tyrosine kinase inhibitors. Therefore, it can provide a guidance to individualize treatments for cancer patients.

摘要翻译： 本发明涉及EGFR基因突变的检测方法和检测试剂盒，其涉及分子靶向抗癌药物的治疗功效。 特别地，本发明涉及用于检测EGFR基因热点突变的荧光定量PCR方法及试剂盒及其应用。 本发明检测EGFR基因特异位点的突变，可预测EGFR酪氨酸激酶抑制剂的治疗效果。 因此，可以为个体化癌症患者的治疗提供指导。

公开(公告)号：US20120288862A1

公开(公告)日：2012-11-15

申请号：US13520176

申请日：2010-12-29

申请人： Junpu Xu ,  Zhao Chen

发明人： Junpu Xu ,  Zhao Chen

IPC分类号： G01N21/64 ,  C12N15/63

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The present invention relates to an assay kit for quantitatively detecting k-ras gene mutations. Particularly, the present invention relates to detection method and a detection kit for K-ras gene mutations, which relates to the therapeutic efficacy of targeted molecular anti-cancer drugs. More particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of K-ras gene, together with the use thereof. The present invention detects the mutations at specific sites of K-ras gene, and can predict the therapeutic efficacy of anti-EGFR tyrosine kinase inhibitors. Therefore, it can provide a guidance to individualized treatments for cancer patients.

摘要翻译： 本发明涉及用于定量检测k-ras基因突变的测定试剂盒。 特别地，本发明涉及K-ras基因突变的检测方法和检测试剂盒，涉及靶向分子抗癌药物的治疗功效。 更具体地，本发明涉及用于检测K-ras基因的热点的突变的荧光定量PCR方法和试剂盒及其用途。 本发明检测K-ras基因特异位点的突变，可预测抗EGFR酪氨酸激酶抑制剂的治疗效果。 因此，可为癌症患者的个体化治疗提供指导。

公开(公告)号：US5556921A

公开(公告)日：1996-09-17

申请号：US195545

申请日：1994-02-14

申请人： Stoil Dirlikov ,  Zhao Chen

发明人： Stoil Dirlikov ,  Zhao Chen

IPC分类号： C08F8/00 ,  C08K3/00 ,  C09D133/06 ,  C08K3/10 ,  C08J3/24

CPC分类号： C08F8/00 ,  C08K3/0075 ,  C09D133/062

摘要： This invention is directed to a fast curing polymer composition which does not require baking or thermosetting to provide a cross-linked coating binder. The composition comprises a polymer which is a homopolymer or copolymer of alpha, beta unsaturated monomers having pendent acetylenic groups which cross-link upon air drying to provide a coating binder.

摘要翻译： 本发明涉及快速固化聚合物组合物，其不需要烘烤或热固化以提供交联的涂料粘合剂。 组合物包含聚合物，其是具有侧链炔基的α，β不饱和单体的均聚物或共聚物，其在空气干燥时交联以提供涂料粘合剂。

公开(公告)号：US08779077B2

公开(公告)日：2014-07-15

申请号：US13415470

申请日：2012-03-08

申请人： Guillermo C. Bazan ,  Lei Ying ,  Zhao Chen ,  Thuc-Quyen Nguyen

发明人： Guillermo C. Bazan ,  Lei Ying ,  Zhao Chen ,  Thuc-Quyen Nguyen

IPC分类号： C08G79/08

CPC分类号： C08G79/08 ,  C08G61/02 ,  C08G2261/126 ,  C08G2261/143 ,  C08G2261/146 ,  C08G2261/3142 ,  C08G2261/411 ,  C08G2261/414 ,  C08G2261/91 ,  C08G2261/92 ,  C08G2261/94 ,  C08G2261/95 ,  H01L51/0039 ,  H01L51/5072

摘要： A method for the production neutral triblock all-conjugated copolymers by palladium-catalyzed chain-growth polymerization, and methods to convert these copolymers into all-conjugated triblock polyelectrolytes with well-controlled molecular weight and polydispersity. A device is provided which incorporates such all-conjugated triblock polyelectrolytes as an electron injection layer.

摘要翻译： 通过钯催化的链增长聚合制备中性三嵌段全共轭共聚物的方法，以及将这些共聚物转变为具有良好控制的分子量和多分散性的全共轭三嵌段聚电解质的方法。 提供了一种装配有这样的全共轭三嵌段聚电解质作为电子注入层的装置。

公开(公告)号：US5962197A

公开(公告)日：1999-10-05

申请号：US49294

申请日：1998-03-27

申请人： Zhao Chen

发明人： Zhao Chen

IPC分类号： C11D3/02 ,  C11D3/20 ,  C11D3/28 ,  C11D3/30 ,  C11D11/00 ,  G03F7/42 ,  H01L21/311 ,  G03C5/00 ,  B08B7/00

CPC分类号： C11D3/044 ,  C11D11/0047 ,  C11D3/2068 ,  C11D3/28 ,  C11D3/30 ,  G03F7/425 ,  H01L21/31133

摘要： A stripper for removing photoresist or solder masks has a composition of 30-80% by weight of a propylene glycol ether; 10-60% by weight of a pyrrolidone; 0.1-5% by weight of potassium hydroxide; 0.1-10% by weight of a surfactant; 0-20% by weight 1,3-butanediol; 0-10% by weight 2-(2-aminoethoxy) ethanol; and a water content of

摘要翻译： 用于除去光致抗蚀剂或焊接掩模的剥离器具有30-80重量％的丙二醇醚的组成; 10-60重量％的吡咯烷酮; 0.1-5重量％的氢氧化钾; 0.1-10重量％的表面活性剂; 0-20重量％1,3-丁二醇; 0-10重量％2-（2-氨基乙氧基）乙醇; 含水量<1％。

公开(公告)号：US5559189A

公开(公告)日：1996-09-24

申请号：US195541

申请日：1994-02-14

申请人： Stoil Dirlikov ,  Zhao Chen

发明人： Stoil Dirlikov ,  Zhao Chen

IPC分类号： C08F8/00 ,  C08F8/32

CPC分类号： C08F8/00

摘要： This invention is directed to fast curing polymer compositions, These compositions comprise a blend of (1) a polymer having pendent activated acetylenic groups and ammonia or a comonomer having at least two functional groups which are reactive with the activated acetylenic groups of the polymer, or (2) a blend of a monomer having at least two activated acetylenic groups and ammonia and/or a comonomer having at least two functional groups which are reactive with the activated acetylenic groups of the monomer.

摘要翻译： 本发明涉及快速固化聚合物组合物，这些组合物包含（1）具有侧活性炔属基团的聚合物和氨或具有至少两个与聚合物的活化炔基反应的官能团的共聚单体的共混物，或 （2）具有至少两个活化炔基的单体与氨和/或具有至少两个与单体的活化炔基反应的官能团的共聚单体的共混物。