CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCER AND METHOD OF FABRICATING THE SAME

    公开(公告)号:US20200298275A1

    公开(公告)日:2020-09-24

    申请号:US16822018

    申请日:2020-03-18

    Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

    Method of Fabricating Block-Copolymer-based 3D Polymorphic Artificial Bilayer Membrane Structure

    公开(公告)号:US20230271179A1

    公开(公告)日:2023-08-31

    申请号:US17992084

    申请日:2022-11-22

    Abstract: The present invention relates to a method for manufacturing a three-dimensional structure based on a block copolymer. The method comprises the steps of injecting a block copolymer (BCP) solution into each micro-well formed on the substrate and drying it to form a block copolymer layer, and applying a buffer to the block copolymer layer to hydrate the micro-well in three dimensions Forming the structure, after the three-dimensional structure is formed, injecting and curing a hydrogel solution around the three-dimensional structure may include the step of enhancing stability. In particular, the process of hydration by applying a buffer to the micro-well is performed while an electric field is applied. By controlling the concentration of the block copolymer (BCP) and the amplitude and frequency of the electric field, a three-dimensional artificial cell membrane having a desired size and shape, such as a spherical or ciliary shape and high stability (100% survival for 50 days) is manufactured can do. The present invention can be efficiently applied to various biological fields such as artificial cells, cell-mimicking biosensors, and bioreactors.

    PREPARING METHOD OF TIGHTLY SEALED 3D LIPID STRUCTURE AND TIGHTLY SEALED 3D LIPID STRUCTURE PREPARED THEREBY

    公开(公告)号:US20200087807A1

    公开(公告)日:2020-03-19

    申请号:US16369533

    申请日:2019-03-29

    Abstract: A method for preparing a tightly sealed 3D lipid structure and a tightly sealed 3D lipid structure prepared thereby is disclosed. The method allows for simpler and more convenient preparation of an artificial biomembrane structure on a substrate using a lipid material, by using a plurality of transparent microwells formed on the substrate, and observation inside the microwells. In addition, a spherical 3D artificial single bilayer structure may be sealed very tightly through a simple method of changing the frequency of an electric field applied vertically to the microwells having a lipid layer formed. Through this, a biomimetic 3D structure having the structural and/or functional characteristics of a cell membrane constituting a cell can be provided more effectively.

    CANTILEVER SENSOR WITH SLIT AND BIOSENSOR HAVING THE SAME
    7.
    发明申请
    CANTILEVER SENSOR WITH SLIT AND BIOSENSOR HAVING THE SAME 有权
    带有滑块的CANTILEVER传感器和具有相同功能的生物传感器

    公开(公告)号:US20150253313A1

    公开(公告)日:2015-09-10

    申请号:US14575129

    申请日:2014-12-18

    Abstract: The present disclosure relates to a cantilever sensor, and a biosensor having the same, wherein the cantilever sensor including a slit formed on a flat board and a cantilever formed by the slit, a first electrode formed on the cantilever, and a second electrode formed on the flat board countered to the first electrode about the slit, wherein the electrodes are formed on the cantilever sensor having the slit, whereby sensing can be conducted by an electric method, through which the sensor can be effectively miniaturized.

    Abstract translation: 本发明涉及一种悬臂传感器及具有该悬臂传感器的生物传感器,其中,悬臂传感器包括形成在平板上的狭缝和由狭缝形成的悬臂,形成在悬臂上的第一电极和形成在悬臂上的第二电极 扁平板围绕狭缝对抗第一电极,其中电极形成在具有狭缝的悬臂传感器上,由此可以通过电气方法进行感测,通过该方法可以有效地使传感器小型化。

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