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    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES
    4.
    发明申请
    METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES 有权
    与改进的碳水化合物分析相关的方法和产品

    公开(公告)号：US20100144553A1

    公开(公告)日：2010-06-10

    申请号：US12623070

    申请日：2009-11-20

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B40/12

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G06F19/703

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。

    COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING INFLUENZA INFECTION
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING INFLUENZA INFECTION 有权
    用于诊断和/或治疗流感病毒感染的组合物和方法

    公开(公告)号：US20110033490A1

    公开(公告)日：2011-02-10

    申请号：US12829931

    申请日：2010-07-02

    申请人： Akila Jayaraman ,  Karthik Viswanathan ,  Rahul Raman ,  Zachary H. Shriver ,  Ram Sasisekharan

    发明人： Akila Jayaraman ,  Karthik Viswanathan ,  Rahul Raman ,  Zachary H. Shriver ,  Ram Sasisekharan

    IPC分类号： A61K39/12 ,  C07K14/00 ,  A61K38/16 ,  A61P31/16 ,  C12Q1/70

    CPC分类号： G01N33/56983 ,  C07K14/005 ,  C12N2760/16122 ,  G01N2333/11 ,  G01N2800/50

    摘要： The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.

    摘要翻译： 本发明提供结合伞形拓扑聚糖的HA多肽（例如，H1 HA多肽），以及与其相关的试剂和方法。 本发明提供了结合HA多肽（例如，H1HA多肽）的结合剂，以及与其相关的试剂和方法。 本发明提供抑制HA多肽（例如H1 HA多肽）与HA受体结合的干扰剂，以及与其相关的试剂和方法。 本发明提供了使用HA多肽，HA多肽结合剂，HA多肽干扰剂和/或包含任何前述物质的疫苗组合物来治疗，预防和/或诊断流感感染的组合物和方法。

    Methods and products related to the improved analysis of carbohydrates
    10.
    发明申请
    Methods and products related to the improved analysis of carbohydrates 审中-公开
    与碳水化合物改进分析有关的方法和产品

    公开(公告)号：US20060127950A1

    公开(公告)日：2006-06-15

    申请号：US11244826

    申请日：2005-10-06

    申请人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    发明人： Carlos Bosques ,  Nishla Keiser ,  Aravind Srinivasan ,  Rahul Raman ,  Karthik Viswanathan ,  Ram Sasisekharan ,  Pankaj Gandhe ,  Sasi Raguram

    IPC分类号： C40B40/10 ,  G01N33/53 ,  C12P21/06

    CPC分类号： G01N33/6851 ,  G01N33/66 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2400/10 ,  G16C20/20

    摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.

    摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。