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1.发明授权Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines 有权流感治疗和/或表征，人类适应的HA多肽; 疫苗公开(公告)号：US08802110B2
公开(公告)日：2014-08-12
申请号：US13239376
申请日：2011-09-21
IPC分类号： A61K39/145 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16133 , C12N2760/16134 , G01N33/56983 , G01N2333/11
摘要： The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
摘要翻译： 本发明尤其提供用于治疗，检测，分析和/或表征流感感染的方法，试剂和系统。
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2.发明申请INFLUENZA TREATMENT AND/OR CHARACTERIZATION, HUMAN-ADAPTED HA POLYPEPTIDES; VACCINES 有权流感病毒治疗和/或表征，人类适应的HA多肽; 疫苗公开(公告)号：US20120219585A1
公开(公告)日：2012-08-30
申请号：US13239376
申请日：2011-09-21
IPC分类号： A61K39/145 , A61P31/16 , C12Q1/70 , C07K14/11
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C07K16/1018 , C12N7/00 , C12N2760/16122 , C12N2760/16133 , C12N2760/16134 , G01N33/56983 , G01N2333/11
摘要： The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.
摘要翻译： 本发明尤其提供用于治疗，检测，分析和/或表征流感感染的方法，试剂和系统。
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3.发明申请公开(公告)号：US20090269342A1
公开(公告)日：2009-10-29
申请号：US12348266
申请日：2009-01-02
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K16/18 , C12N7/00 , A61K38/02 , C40B40/10 , C40B30/04 , G01N33/566
CPC分类号： G01N33/56983 , C07K14/005 , C12N2760/16122 , G01N2333/11 , G01N2400/10 , G01N2500/02
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
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4.发明申请HEMAGGLUTININ POLYPEPTIDES, AND REAGENTS AND METHODS RELATING THERETO 审中-公开HEMAGGLUTININ POLYPEPTIDES，以及与其相关的试剂和方法公开(公告)号：US20090081193A1
公开(公告)日：2009-03-26
申请号：US11969040
申请日：2008-01-03
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , C07K14/435 , C07H21/00 , C12N15/64 , C12N1/21 , A61K31/7088 , A61P31/16 , C07K16/08 , C12N7/01 , C40B40/12 , A61K38/16
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
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公开(公告)号：US08815522B2
公开(公告)日：2014-08-26
申请号：US12348265
申请日：2009-01-02
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： G01N33/53 , A61K31/702 , A61K31/715 , C07H3/06
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2400/10
摘要： The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.
摘要翻译： 本发明提供伞形拓扑聚糖诱饵。 本发明提供利用本发明的伞形拓扑聚糖诱饵治疗流感感染的系统和方法。 本发明提供了鉴定新型伞形拓扑聚糖诱饵的方法。
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6.发明申请公开(公告)号：US20100061990A1
公开(公告)日：2010-03-11
申请号：US12301126
申请日：2007-08-14
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , G01N33/53 , C40B40/12
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供了结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
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公开(公告)号：US20100004195A1
公开(公告)日：2010-01-07
申请号：US12348265
申请日：2009-01-02
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K31/702 , C12Q1/70 , C07H1/00
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2400/10
摘要： The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.
摘要翻译： 本发明提供伞形拓扑聚糖诱饵。 本发明提供利用本发明的伞形拓扑聚糖诱饵治疗流感感染的系统和方法。 本发明提供了鉴定新型伞形拓扑聚糖诱饵的方法。
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8.发明申请公开(公告)号：US20080241918A1
公开(公告)日：2008-10-02
申请号：US11893171
申请日：2007-08-14
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
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公开(公告)号：US20060067927A1
公开(公告)日：2006-03-30
申请号：US11171490
申请日：2005-06-29
申请人： Aarthi Chandrasekaran , Shiladitya Sengupta , David Berry , Kristine Holley , Ganlin Zhao , Ram Sasisekharan
发明人： Aarthi Chandrasekaran , Shiladitya Sengupta , David Berry , Kristine Holley , Ganlin Zhao , Ram Sasisekharan
IPC分类号： A61K38/47 , A61K31/737 , A61K31/727
CPC分类号： A61K38/51 , A61K31/00 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/45 , A61K45/06 , A61K47/36 , A61K2300/00
摘要： The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.
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公开(公告)号：US20070212786A1
公开(公告)日：2007-09-13
申请号：US11540695
申请日：2006-09-29
申请人： Scott Manalis , Tzu Loh , Michel Godin , Nebojsa Milovic , Jonathan Behr , Aarthi Chandrasekaran , Ram Sasisekharan
发明人： Scott Manalis , Tzu Loh , Michel Godin , Nebojsa Milovic , Jonathan Behr , Aarthi Chandrasekaran , Ram Sasisekharan
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , B01L3/5027 , G01N27/4145 , G01N2333/8128
摘要： In one aspect, the present invention provides a device and method for real-time, direct detection of heparin in buffer and in serum comprising a microfluidic field-effect device as an affinity biosensor. The sensor is based on an electrolyte-insulator-silicon structure, and is manufactured by a standard high-yield silicon microfabrication process. The binding of heparin to the sensor surface induces a change in the insulator-electrolyte surface potential, which is measured as a change in sensor capacitance. To ensure the binding selectivity, protamine and antithrombin III are used as affinity probes.
摘要翻译： 一方面，本发明提供了用于在缓冲液和血清中实时，直接检测肝素的装置和方法，其包括作为亲和生物传感器的微流场效应装置。 该传感器基于电解质 - 绝缘体 - 硅结构，并通过标准的高产率硅微细加工工艺制造。 肝素与传感器表面的结合导致绝缘体 - 电解质表面电位的变化，其被测量为传感器电容的变化。 为了确保结合选择性，使用鱼精蛋白和抗凝血酶III作为亲和探针。
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