公开(公告)号：US08877951B2

公开(公告)日：2014-11-04

申请号：US14351786

申请日：2012-10-24

Applicant: Kansas State University Research Foundation

Inventor： Hongwang Wang ,  Stefan Bossmann ,  Byungjun Kollbe Ahn ,  Xiuzhi Susan Sun

IPC: B01J31/28 ,  C07D307/48

CPC classification number: B01J31/28 ,  B01J23/745 ,  B01J23/8986 ,  B01J23/94 ,  B01J23/96 ,  B01J31/08 ,  B01J31/10 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/002 ,  B01J35/0033 ,  B01J35/008 ,  B01J35/08 ,  B01J35/1014 ,  B01J35/1019 ,  B01J37/0209 ,  B01J37/031 ,  B01J37/343 ,  B01J38/72 ,  C07C67/343 ,  C07D307/48 ,  Y02P20/584 ,  Y10T428/2995 ,  C07C69/58

Abstract: Superparmagnetic acid-functionalized nanoparticle catalysts are provided along with methods of using the same to protonate an oxygen atom of a carbon-oxygen bond. Particularly, the catalysts comprise a nanoparticle having a ferromagnetic core surrounded by a metal oxide shell. The nanoparticle is at least partially coated with an acid-functionalized siloxane compound. The acid-functionalized nanoparticles may be used to catalyze any number of reactions that can be catalyzed in the presence of protons. The ferromagnetic core permits the nanoparticle catalyst material to be separated from the reaction medium through application of a magnetic field and reused.

Abstract translation: 提供了超磁性酸官能化纳米颗粒催化剂及其使用方法来质子化氧 - 氧键的氧原子。 特别地，催化剂包括具有被金属氧化物壳包围的铁磁性核的纳米颗粒。 纳米颗粒至少部分地涂覆有酸官能化的硅氧烷化合物。 酸官能化的纳米颗粒可用于催化任何数量的可在质子存在下催化的反​​应。 铁磁芯允许通过施加磁场将纳米颗粒催化剂材料与反应介质分离并重复使用。

公开(公告)号：US20140275583A1

公开(公告)日：2014-09-18

申请号：US14351786

申请日：2012-10-24

Applicant: Kansas State University Research Foundation

Inventor： Hongwang Wang ,  Stefan Bossmann ,  Byungjun Kollbe Ahn ,  Xiuzhi Susan Sun

IPC: B01J31/28 ,  C07D307/48

CPC classification number: B01J31/28 ,  B01J23/745 ,  B01J23/8986 ,  B01J23/94 ,  B01J23/96 ,  B01J31/08 ,  B01J31/10 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/002 ,  B01J35/0033 ,  B01J35/008 ,  B01J35/08 ,  B01J35/1014 ,  B01J35/1019 ,  B01J37/0209 ,  B01J37/031 ,  B01J37/343 ,  B01J38/72 ,  C07C67/343 ,  C07D307/48 ,  Y02P20/584 ,  Y10T428/2995 ,  C07C69/58

Abstract: Superparmagnetic acid-functionalized nanoparticle catalysts are provided along with methods of using the same to protonate an oxygen atom of a carbon-oxygen bond. Particularly, the catalysts comprise a nanoparticle having a ferromagentic core surrounded by a metal oxide shell. The nanoparticle is at least partially coated with an acid-functionalized siloxane compound. The acid-functionalized nanoparticles may be used to catalyze any number of reactions that can be catalyzed in the presence of protons. The ferromagnetic core permits the nanoparticle catalyst material to be separated from the reaction medium through application of a magnetic field and reused.

Abstract translation: 提供了超磁性酸官能化纳米颗粒催化剂及其使用方法来质子化氧 - 氧键的氧原子。 特别地，催化剂包含具有由金属氧化物壳包围的铁心的纳米颗粒。 纳米颗粒至少部分地涂覆有酸官能化的硅氧烷化合物。 酸官能化的纳米颗粒可用于催化任何数量的可在质子存在下催化的反​​应。 铁磁芯允许通过施加磁场将纳米颗粒催化剂材料与反应介质分离并重复使用。

公开(公告)号：US20140357837A1

公开(公告)日：2014-12-04

申请号：US14461708

申请日：2014-08-18

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi Susan Sun ,  Hongzhou Huang

IPC: C07K1/113

CPC classification number: C07K1/1136 ,  A61K38/10 ,  A61K51/1213 ,  A61L27/22 ,  A61L27/52 ,  C07K7/00 ,  C07K14/00

Abstract: The present invention broadly provides novel peptides that can be used to form hydrogels. The peptides are short (preferably 30 amino acid residues or less) and include hydrophilic and hydrophobic segments joined by a turning segment. The hydrogels are formed by altering the pH of a solution of these peptides to an acidic level, or by introducing a source of ions into a solution of these peptides. The resulting hydrogels are shear thinning gels that have high storage moduli and high rates of recovery after destruction. They find use in medical applications, including tissue engineering.

Abstract translation: 本发明广泛地提供可用于形成水凝胶的新型肽。 肽短（优选30个氨基酸残基或更少），并且包括通过转动部分连接的亲水和疏水部分。 通过将这些肽的溶液的pH改变到酸性水平，或通过将离子源引入这些肽的溶液中而形成水凝胶。 所得水凝胶是具有高储存模量和破坏后高回收率的剪切稀化凝胶。 它们用于医疗应用，包括组织工程。