公开(公告)号：US5998012A

公开(公告)日：1999-12-07

申请号：US716376

申请日：1996-09-19

申请人： Karl-Hermann Friese ,  Lothar Weber ,  Werner Gruenwald ,  Gert Lindemann ,  Harald Neumann ,  Ulrich Eisele

发明人： Karl-Hermann Friese ,  Lothar Weber ,  Werner Gruenwald ,  Gert Lindemann ,  Harald Neumann ,  Ulrich Eisele

IPC分类号： G01N27/409 ,  B32B18/00 ,  C04B35/00 ,  C04B41/50 ,  C04B41/87 ,  G01N27/407 ,  B23B17/00

CPC分类号： C04B41/009 ,  B32B18/00 ,  C04B41/5042 ,  C04B41/87 ,  G01N27/4073 ,  G01N27/4075 ,  C04B2237/34 ,  C04B2237/341 ,  C04B2237/343 ,  C04B2237/348 ,  Y10T428/252 ,  Y10T428/256 ,  Y10T428/257

摘要： A ceramic layer system including at least two layers having respective ion conductivities which are substantially different includes a substrate layer composed of a ceramic material and having substantially no ion conductivity; and at least one conducting layer positioned adjacent to the substrate layer, containing coated ceramic particles composed of ceramic particles composed of a ceramic material having no substantial ion conductivity which are coated with a material having a substantial ion conductivity so that each conducting layer of the at least one conducting layer has a continuous phase after sintering composed of the material which has a substantial ion conductivity and so that the at least one conducting layer has an ion conductivity effective to conduct ions. A method of producing a gas sensor for detecting small quantities of at least one gas in gas mixtures includes providing a substrate layer composed of ceramic particles composed of a material having substantially no ion conductivity; applying a layer composed of coated ceramic particles onto the substrate layer, the coated ceramic particles being composed of ceramic particles composed of a material that has no substantial ion conductivity coated with a material which has a substantial ion conductivity at the operating temperature of the gas sensor; applying at least one functional layer onto the layer composed of coated ceramic particles to provide a green body; preheating the green body to remove binding agents, plastifying agents, and any additional organic constituents; and sintering the green body after preheating by heating to a temperature effective to sinter the green body so that the layer comprised of coated ceramic particles has a continuous phase comprised of the material which has a substantial ion conductivity.

公开(公告)号：US5885429A

公开(公告)日：1999-03-23

申请号：US860661

申请日：1997-08-08

申请人： Karl-Hermann Friese ,  Werner Gruenwald ,  Kurt Schmid ,  Claudio De La Prieta ,  Gerhard Schneider ,  Hans-Joerg Renz ,  Harald Neumann ,  Uwe Glanz ,  Stefan Kuschel ,  Ralf Haug ,  Manfred Moser ,  Kurt Bayha ,  Annette Seibold ,  Carmen Schmiedel ,  Reiner Schuetz

发明人： Karl-Hermann Friese ,  Werner Gruenwald ,  Kurt Schmid ,  Claudio De La Prieta ,  Gerhard Schneider ,  Hans-Joerg Renz ,  Harald Neumann ,  Uwe Glanz ,  Stefan Kuschel ,  Ralf Haug ,  Manfred Moser ,  Kurt Bayha ,  Annette Seibold ,  Carmen Schmiedel ,  Reiner Schuetz

IPC分类号： G01N27/409 ,  G01N27/407 ,  G01N27/26

CPC分类号： G01N27/4075

摘要： An electrochemical measuring sensor having a solid electrolyte, a first electrode exposed to a gas to be measured and a second electrode exposed to a reference gas, with the electrodes preferably being arranged on opposite sides of the solid electrolyte. At least one of the electrodes (16, 20) is provided with a contouring (24) on its side (22) that is exposed to the gas to be measured or to the reference gas, with the contouring being a trench-shaped groove (26) embossed into the surface of the electrode such that the electrode is pressed into the adjacent solid electrolyte in the region of the groove. According to the method, the embossing is done while the electrode and the solid electrolyte are in the non-sintered state, and the sensor is subsequently sintered.

摘要翻译： PCT No.PCT / DE96 / 01753 Sec。 371日期：1997年8月8日 102（e）日期1997年8月8日PCT提交1996年9月17日PCT公布。 公开号WO97 / 17608 日期1997年5月15日具有固体电解质的电化学测量传感器，暴露于待测气体的第一电极和暴露于参考气体的第二电极，电极优选布置在固体电解质的相对侧上。 电极（16,20）中的至少一个在其侧面（22）处设置有暴露于待测量气体或参考气体的轮廓（24），其中轮廓是沟槽形凹槽 26）压印到电极的表面中，使得电极在凹槽的区域中被压入相邻的固体电解质中。 根据该方法，在电极和固体电解质处于非烧结状态下进行压花，随后将传感器烧结。

公开(公告)号：US5545301A

公开(公告)日：1996-08-13

申请号：US360737

申请日：1994-12-23

申请人： Karl-Hermann Friese ,  Werner Gruenwald ,  Roland Stahl ,  Claudio de la Prieta ,  Gerhard Schneider ,  Harald Neumann

发明人： Karl-Hermann Friese ,  Werner Gruenwald ,  Roland Stahl ,  Claudio de la Prieta ,  Gerhard Schneider ,  Harald Neumann

IPC分类号： G01N27/41 ,  G01N27/407 ,  G01N27/26

CPC分类号： G01N27/4071

摘要： A sensor element for determining concentration of at least one constituent of a gas mixture operates on an electro-chemical measuring process and includes a gas measuring chamber; a pair of electrodes and an electrode chamber located between the pair of electrodes; and a diffusion conduit adjoining the electrode chamber and having a gas input which connects with the gas measuring chamber, having a gas output which connects with the electrode chamber, and having at least one cross-sectional area including a height, w, and a length, L, which height, w, has a preselected minimum value, and which length, L, has a value which is equal to or greater than the preselected minimum value of the height, w. The constituent of the gas mixture has a mean free path length through the sensor element, the gas measuring chamber has a cross-sectional area including a height and a length each of which are at least as large as the minimum height, w, of the diffusion conduit, and the height, w, of respective ones of the at least one cross-sectional area of the diffusion conduit is at least a multiple of the mean free path length of the constituent of the gas mixture to be measured. Advantageously, substantially only gaseous phase diffusion occurs when the predetermined minimum value of the height, w, is at least a multiple of a minimum value of the mean free path length for the gas constituent measured.

摘要翻译： 用于确定气体混合物的至少一种组分的浓度的传感器元件在电化学测量过程中运行，并且包括气体测量室; 位于所述一对电极之间的一对电极和电极室; 以及邻接所述电极室并具有与所述气体测量室连接的气体输入的扩散管道，具有与所述电极室连接的气体输出，并且具有包括高度w和长度的至少一个横截面区域 ，L，其高度w具有预选的最小值，并且长度L具有等于或大于预定的最小值的最小值w的值。 气体混合物的组分具有通过传感器元件的平均自由路径长度，气体测量室具有包括高度和长度的横截面积，每个高度和长度至少与最小高度w一样大， 扩散管道的扩散管道，并且扩散管道的至少一个横截面积中相应的一个的高度w至少为要测量的气体混合物的成分的平均自由程长度的倍数。 有利地，当高度的预定最小值w至少为测量的气体成分的平均自由程长度的最小值的倍数时，基本上仅发生气相扩散。

公开(公告)号：US5476001A

公开(公告)日：1995-12-19

申请号：US244660

申请日：1994-06-06

申请人： Gerhard Hoetzel ,  Harald Neumann ,  Johann Riegel ,  Karl-Hermann Friese ,  Werner Gruenwald

发明人： Gerhard Hoetzel ,  Harald Neumann ,  Johann Riegel ,  Karl-Hermann Friese ,  Werner Gruenwald

IPC分类号： G01N27/12 ,  G01N27/14 ,  G01N27/416 ,  G01N27/419 ,  G01N27/62 ,  G01N27/417 ,  F02D41/14

CPC分类号： G01N27/419

摘要： A sensor for determining gas components and/or gas concentrations in gas mixtures, in particular in exhaust gases of internal combustion engines. The sensor has an oxygen pump cell and a measuring element having a sensitive region. Provided between the pump cell and the gas mixture is a diffusion path in which there are formed an oxygen gradient XO.sub.2 and a gradient X.sub.CO of the gas component to be determined, which extend respectively in opposite directions. The measuring element is positioned relative to the pump cell and the diffusion path in such a way that an excess of oxygen is present on the sensitive region of the measuring element.

摘要翻译： PCT No.PCT / DE93 / 01164 Sec。 371日期：1994年6月6日 102（e）日期1994年6月6日PCT提交1993年12月7日PCT公布。 公开号WO94 / 15206 日期1997年7月7日。一种用于确定气体混合物，特别是内燃机废气中的气体成分和/或气体浓度的传感器。 传感器具有氧气泵电池和具有敏感区域的测量元件。 提供在泵电池和气体混合物之间的是扩散路径，其中形成分别沿相反方向延伸的要确定的气体成分的氧梯度XO2和梯度XCO。 测量元件相对于泵电池和扩散路径被定位成使得过量的氧存在于测量元件的敏感区域上。

公开(公告)号：US5406246A

公开(公告)日：1995-04-11

申请号：US971778

申请日：1993-02-12

申请人： Karl-Hermann Friese ,  Harald Neumann

发明人： Karl-Hermann Friese ,  Harald Neumann

IPC分类号： G01K7/18 ,  G01K7/22 ,  H01C7/02 ,  H01C7/10 ,  H01C1/012

CPC分类号： G01K7/18 ,  Y10T29/49085

摘要： A positive temperature coefficient temperature sensor for use in exhaust-gas systems of internal-combustion engines includes a sensor element having a multilayer laminate composite structure with a positive temperature coefficient thermistor, formed by at least two resistor tracks arranged one above another and electrically insulated from one another. One of the layers of the multilayer structure is an insulating ceramic base film, and a first one of the at least two resistor tracks, with a supply lead, is printed onto the insulating ceramic base film. A second one of the at least two resistor tracks is disposed separately on the insulating ceramic base film by means of at least one insulating layer printed above the first one of the at least two resistor tracks. The at least two resistor tracks disposed one above another are connected by a land guided through the at least one insulating layer. A further film is subsequently laminated on the surface of the insulating ceramic base film printed with the at least two resistor tracks. The at least two resistor tracks are hermetically sealed by the laminate composite structure with respect to a gas being measured and environmental air.

摘要翻译： PCT No.PCT / DE91 / 00601 Sec。 371日期：1993年2月12日 102（e）日期1993年2月12日PCT 1991年7月25日PCT公布。 出版物WO92 / 03711 日本3月5日，1992年。用于内燃机废气系统的正温度系数温度传感器包括具有正温度系数热敏电阻的多层层压复合结构的传感器元件，该正温度系数热敏电阻由至少两个电阻轨道排列 一个在另一个之上并且彼此电绝缘。 多层结构的层之一是绝缘陶瓷基膜，并且具有供电引线的至少两个电阻轨道中的第一个被印刷到绝缘陶瓷基膜上。 所述至少两个电阻轨道中的第二个通过至少一个印刷在所述至少两个电阻轨迹中的所述至少两个电阻轨迹上的绝缘层分开设置在所述绝缘陶瓷基底膜上。 一个上面设置的至少两个电阻轨道通过穿过至少一个绝缘层引导的平台连接。 随后，在印刷有至少两个电阻轨道的绝缘陶瓷基底膜的表面上层压另外的膜。 至少两个电阻轨道相对于被测量的气体和环境空气被叠层复合结构气密密封。

公开(公告)号：US5505837A

公开(公告)日：1996-04-09

申请号：US290704

申请日：1994-12-12

申请人： Karl-Hermann Friese ,  Hermann Dietz ,  Werner Gruenwald ,  Gerhard Hoetzel ,  Harald Neumann ,  Johann Riegel ,  Bernd Schumann

发明人： Karl-Hermann Friese ,  Hermann Dietz ,  Werner Gruenwald ,  Gerhard Hoetzel ,  Harald Neumann ,  Johann Riegel ,  Bernd Schumann

IPC分类号： G01N27/12 ,  G01N27/416 ,  G01N27/419 ,  G01N27/26

CPC分类号： G01N27/419

摘要： A sensor arrangement for determining at least one of gas components and gas concentrations of gas mixtures including CO, NO.sub.x and HC in exhaust gases of internal combustion engines, includes a measuring element which has a sensitive region; and a pump cell that includes a solid electrolyte and inner and outer pump electrodes which are opposingly disposed at least on the solid electrolyte and which effect an oxygen transfer to the measuring element, wherein the pump cell and the measuring element are spatially separated from one another, are located in different temperature zones during operation of the sensor arrangement, and are connected to one another by a diffusion segment through which oxygen can diffuse from the pump cell to the measuring element.

摘要翻译： PCT No.PCT / DE94 / 00289 Sec。 371日期1994年12月12日第 102（e）日期1994年12月12日PCT 1994年3月17日PCT公布。 公开号WO94 / 24550 PCT 日期：1994年10月27日。一种用于确定内燃机废气中的CO，NO x和HC气体混合气体组分和气体浓度中的至少一种的传感器装置，包括具有敏感区域的测量元件; 以及泵电池，其包括固体电解质和内部和外部泵电极，所述内部和外部泵电极相对设置在至少在所述固体电解质上并且对所述测量元件进行氧传递，其中所述泵浦单元和所述测量元件在空间上彼此分离 位于传感器装置的操作期间的不同温度区域中，并且通过扩散段彼此连接，通过该扩散段，氧气可以从泵电池扩散到测量元件。

公开(公告)号：US20120183509A1

公开(公告)日：2012-07-19

申请号：US13266858

申请日：2010-04-28

申请人： Harald Neumann ,  Martin Glas ,  Ruslan Masgutov ,  Ulrich Herrlinger ,  Kristian Welle

发明人： Harald Neumann ,  Martin Glas ,  Ruslan Masgutov ,  Ulrich Herrlinger ,  Kristian Welle

IPC分类号： A61K35/30 ,  A61P35/00 ,  C12N5/0735 ,  C12N5/071

CPC分类号： A61K35/30 ,  A61K35/12 ,  C12N5/0622 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2500/44 ,  C12N2500/50 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/235 ,  C12N2501/58 ,  C12N2506/02

摘要： Microglial precursor cells for use in the treatment of malignant neoplasms of the central nervous system. A method of treating malignant neoplasms of the central nervous system comprising administering a pharmaceutically effective amount of microglial precursor cells to a subject in need thereof.

摘要翻译： 用于治疗中枢神经系统恶性肿瘤的小胶质前体细胞。 一种治疗中枢神经系统的恶性肿瘤的方法，包括向有需要的受试者施用药学有效量的小胶质前体细胞。

公开(公告)号：US20120107898A1

公开(公告)日：2012-05-03

申请号：US13266845

申请日：2010-04-28

申请人： Harald Neumann ,  Kristin Roy ,  Oliver Brüstle ,  Michael Peitz

发明人： Harald Neumann ,  Kristin Roy ,  Oliver Brüstle ,  Michael Peitz

IPC分类号： C12N13/00 ,  C12N5/071

CPC分类号： A61K35/30 ,  A61K35/12 ,  C12N5/0622 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2500/44 ,  C12N2500/50 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/235 ,  C12N2501/58 ,  C12N2506/02

摘要： A method for obtaining human microglial precursor cells, comprising: (a) providing a cell population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors; (c) expanding and enriching microglial precursor cells in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors and 10 to 150 ng/ml GM-CSF; and (d) isolating microglial precursor cells comprising CD45-positive cells.

摘要翻译： 一种获得人小胶质细胞前体细胞的方法，包括：（a）提供包含神经前体细胞的细胞群，其中所述细胞群可从人多能干细胞分化的胚状体获得; （b）通过在包含选自胰岛素和胰岛素样生长因子的生长因子的培养基中培养将包含神经前体细胞的细胞群分化为小胶质前体细胞; （c）在包含选自胰岛素和胰岛素样生长因子和10至150ng / ml GM-CSF的生长因子的培养基中扩增和富集小神经胶质前体细胞; 和（d）分离包含CD45阳性细胞的小胶质前体细胞。

公开(公告)号：US20100180974A1

公开(公告)日：2010-07-22

申请号：US12688225

申请日：2010-01-15

申请人： Stefan Gross ,  Harald Neumann

发明人： Stefan Gross ,  Harald Neumann

IPC分类号： F16L25/00

CPC分类号： F16L3/1226 ,  F16L35/00 ,  F16L57/02

摘要： The present embodiments relate to an apparatus which can be used to increase the bending strength of a tube in its connection region. The apparatus may include an adapter unit, the shape of which is matched to a cross-sectional shape of a tube end in such a manner that on the one hand the adapter unit can be fitted to a tube connection of a device instead of the tube end and on the other hand the tube end can be fitted to the adapter unit. The apparatus may also include at least one spring element made of glass fiber reinforced plastic, which is connected to the adapter unit, projects out of the adapter unit in the direction of the tube and has a termination element at the projecting end, against which termination element a fitted tube abuts when subjected to bending, so that the rigidity of the spring element increases the bending strength of the tube in the region between the adapter unit and the element.

摘要翻译： 本实施例涉及一种可用于增加其连接区域中的管的弯曲强度的装置。 该装置可以包括适配器单元，其形状与管端的横截面形状相匹配，使得一方面可将适配器单元装配到设备的管连接件而不是管 另一方面，管端可以装配到适配器单元。 该装置还可以包括连接到适配器单元的由玻璃纤维增​​强塑料制成的至少一个弹簧元件，沿着管的方向从适配器单元突出，并且在突出端处具有终端元件，该终端 元件一个装配的管子在经受弯曲时抵接，使得弹簧元件的刚性增加了在适配器单元和元件之间的区域中的管的弯曲强度。

公开(公告)号：US06645361B1

公开(公告)日：2003-11-11

申请号：US09936815

申请日：2002-01-14

申请人： Bernhard Bloemer ,  Rainer Strohmaier ,  Carsten Springhorn ,  Detlef Heimann ,  Hans-Joerg Renz ,  Harald Neumann ,  Margret Schuele ,  Bernd Schumann ,  Thomas Moser ,  Sabine Thiemann-Handler

发明人： Bernhard Bloemer ,  Rainer Strohmaier ,  Carsten Springhorn ,  Detlef Heimann ,  Hans-Joerg Renz ,  Harald Neumann ,  Margret Schuele ,  Bernd Schumann ,  Thomas Moser ,  Sabine Thiemann-Handler

IPC分类号： G01N27407

CPC分类号： G01N27/417

摘要： An electrochemical gas sensor for determining the concentration of gas components in a gas mixture, in particular for determining NOx and HC. The gas sensor includes a first measuring gas space which is connected to the measuring gas, and a second measuring gas space which is connected to the first measuring gas space by a connecting channel. Furthermore, a first electrode and a second electrode, arranged in the first measuring gas space, and at least one third electrode arranged in the second measuring gas space, and at least one fourth electrode are provided. The two measuring gas spaces are arranged in layer planes on top of one another and are separated from one another by at least one oxygen ion conducting layer, the connecting channel passing through the oxygen ion conducting layer.

摘要翻译： 一种电化学气体传感器，用于确定气体混合物中气体组分的浓度，特别是用于确定NOx和HC。 气体传感器包括连接到测量气体的第一测量气体空间和通过连接通道连接到第一测量气体空间的第二测量气体空间。 此外，设置有布置在第一测量气体空间中的第一电极和第二电极以及布置在第二测量气体空间中的至少一个第三电极和至少一个第四电极。 两个测量气体空间在彼此顶部的层平面中排列，并且通过至少一个氧离子传导层彼此分离，连接通道穿过氧离子传导层。