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148 条记录 (耗时 0.037 秒)

    Process for the preparation of cyclic 4-oxoamidines
    1.
    发明授权
    Process for the preparation of cyclic 4-oxoamidines 失效
    制备环状4-氧代脒的方法

    公开(公告)号：US6037474A

    公开(公告)日：2000-03-14

    申请号：US276345

    申请日：1999-03-25

    申请人： Karlheinz Drauz ,  Rolf Hoffmann ,  Ivan Pilgrims

    发明人： Karlheinz Drauz ,  Rolf Hoffmann ,  Ivan Pilgrims

    IPC分类号： C07D233/32 ,  C07D233/70 ,  C07D235/02

    CPC分类号： C07D233/70 ,  C07D233/32 ,  C07D235/02

    摘要： The present invention relates to a process for the preparation of cyclic 4-oxoamidines. Such substances are precursors of active substances having biological action. The process according to the invention forms a further method of obtaining this class of compound.By reacting condensation products of aldehydes and aminonitriles or amino acid amides with oxidizing agents, the desired cyclic 4-oxoamidines are obtained according to the invention in good to very good yields.

    摘要翻译： 本发明涉及制备环状4-氧代脒的方法。 这些物质是具有生物作用的活性物质的前体。 根据本发明的方法形成获得这类化合物的另一种方法。 通过使醛和氨基腈或氨基酸酰胺的缩合产物与氧化剂反应，根据本发明获得所需的环状4-氧代脒基，得到很好的产率。

    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids
    4.
    发明申请
    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids 审中-公开
    从外消旋的N-酰化β-氨基羧酸制备光学活性β-氨基羧酸的方法

    公开(公告)号：US20050153401A1

    公开(公告)日：2005-07-14

    申请号：US10508088

    申请日：2003-03-07

    申请人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    发明人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    IPC分类号： C12P41/00 ,  C12R1/69 ,  C12P13/04

    CPC分类号： C12P41/007

    摘要： A process is described for preparing optically active β-atninocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by cnantiosclccthc hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R1, R2 are each selected, independently of one another, from H, halogen, alkiyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.

    摘要翻译： 描述了一种用于通过在水解酶存在下通过生物催化剂的N-酰化β-氨基羧酸水解N-外酰基化的β-氨基羧酸来制备光学活性β-阿魏酸的方法，其中N-酰基取代基 的N-酰化的β-氨基羧酸（I）表现出结构I，其中R 1，R 2各自彼此独立地选自H，卤素， 烷基残基，OH，烷氧基残基和芳氧基残基; R 3选自卤素，烷氧基残基和芳氧基残基; （II）结构IIA或IIB或相应盐的结构或（III）结构III或相应盐的结构。

    Method of producing oxazolidinones, the use thereof and oxazolidinones
    10.
    发明授权
    Method of producing oxazolidinones, the use thereof and oxazolidinones 失效
    生产恶唑烷酮的方法，其用途和恶唑烷酮

    公开(公告)号：US06437145B1

    公开(公告)日：2002-08-20

    申请号：US09542278

    申请日：2000-04-04

    申请人： Karlheinz Drauz ,  Günter Knaup ,  Stefan Retzow

    发明人： Karlheinz Drauz ,  Günter Knaup ,  Stefan Retzow

    IPC分类号： C07D26308

    CPC分类号： C07D263/18 ,  C07C231/14 ,  C07C237/22

    摘要： The invention concerns a method of producing oxazolidinones of formula (I), wherein R1-R5 have the meanings given in the description, by reacting cyclical anhydrides of formula (II) with carbonyl compounds of general formula (III) at temperatures between ambient temperature and approximately 150° C. The invention also concerns the production of the cyclical anhydrides of formula (II) by reacting N-protected aminodicarboxylic acids of formula (IV) with a dehydrating agent in situ. The invention further concerns the use of oxazolidinones of formula (I) for the &agr;-selective production of esters of formula (V) and amides of general formula (VII).

    摘要翻译： 本发明涉及一种制备式（I）的恶唑烷酮的方法，其中R1-R5具有本说明书中给出的含义，通式（II）的环状酸酐与通式（III）的羰基化合物在环境温度和 本发明还涉及式（II）的环状酸酐通过将式（Ⅳ）的N-保护的氨基二羧酸与脱水剂原位反应来生产。 本发明还涉及式（I）的恶唑烷酮在通式（Ⅴ）的酯和通式（Ⅶ）的酰胺的α-选择性生产中的应用。