公开(公告)号：US20090313707A1

公开(公告)日：2009-12-17

申请号：US11814361

申请日：2006-05-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330。 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20120030776A1

公开(公告)日：2012-02-02

申请号：US12910746

申请日：2010-10-22

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

IPC分类号： A61K49/00 ,  C12Q1/48 ,  C12Q1/42 ,  C40B30/04 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090113564A1

公开(公告)日：2009-04-30

申请号：US12057851

申请日：2008-03-28

申请人： Alejandro Abuin ,  Mark Dominic Borromeo ,  Katherin E. Combs ,  Ling Ling Culbertson ,  Zhi-Yong Ding ,  Joel Edwards ,  Liangfen Fan ,  Rosemary Girgis ,  Leslie Jane Green ,  Allison Anne Byers Horner ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Brian Zambrowicz

发明人： Alejandro Abuin ,  Mark Dominic Borromeo ,  Katherin E. Combs ,  Ling Ling Culbertson ,  Zhi-Yong Ding ,  Joel Edwards ,  Liangfen Fan ,  Rosemary Girgis ,  Leslie Jane Green ,  Allison Anne Byers Horner ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： A01K67/027

CPC分类号： C12N15/873 ,  A01K2217/05 ,  C12N2799/027

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。

公开(公告)号：US20120005766A1

公开(公告)日：2012-01-05

申请号：US13205917

申请日：2011-08-09

申请人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

发明人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

IPC分类号： A61K49/00 ,  C12Q1/68 ,  C40B30/04 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 循环异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080311107A1

公开(公告)日：2008-12-18

申请号：US11814136

申请日：2007-02-09

申请人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel A. Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Trac Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

发明人： Kristi Rae Bollinger ,  Katherin E. Combs ,  Jaime-Jo Cunningham ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Joel A. Edwards ,  Leslie Jane Green ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Dina Rebecca McLain ,  Charles Montgomery ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Heidi Phillips ,  Trac Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Teresa Gail Townsend ,  Peter Vogel

IPC分类号： A61K39/395 ,  A61K51/00 ,  C12N5/06 ,  A61P25/00 ,  A61P27/12 ,  C07K16/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090288176A1

公开(公告)日：2009-11-19

申请号：US11814025

申请日：2007-04-18

申请人： Kristi Rae Bollinger ,  Frederic J. de Sauvage ,  Joel Edwards ,  Rosemary Girgis ,  Leslie Jane Green ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Carolina Rangel ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Tracy Tzu-Ling Tang ,  Peter Vogel

发明人： Kristi Rae Bollinger ,  Frederic J. de Sauvage ,  Joel Edwards ,  Rosemary Girgis ,  Leslie Jane Green ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Carolina Rangel ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Tracy Tzu-Ling Tang ,  Peter Vogel

IPC分类号： G01N33/00 ,  A61K39/395 ,  C12N5/10 ,  C07K16/00 ,  A01K67/00

CPC分类号： C12Q1/6883 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  C07K14/705 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090077680A1

公开(公告)日：2009-03-19

申请号：US12099465

申请日：2008-04-08

申请人： Alejandro Abuin ,  Joel Edwards ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Teresa Gail Townsend ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Peter Vogel ,  Brian Zambrowicz

发明人： Alejandro Abuin ,  Joel Edwards ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Teresa Gail Townsend ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： A01K67/027 ,  C12N5/06 ,  C07K16/18

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N15/8509 ,  C12N2840/44

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。