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公开(公告)号：US07901457B2
公开(公告)日：2011-03-08
申请号：US10438883
申请日：2003-05-16
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30062 , A61F2002/30136 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30299 , A61F2002/30327 , A61F2002/30764 , A61F2002/30785 , A61F2210/0004 , A61F2230/0004 , A61F2230/0069 , A61F2230/0093 , A61F2250/0014 , A61F2250/0039 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3852 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
摘要翻译： 本发明涉及一种软骨修复组件，其包括软骨下骨的成形同种异体移植结构，其具有整体的上覆软骨帽，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和铣碎的同种异体移植软骨。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得成形骨或软骨盖以过盈配合接合钻孔的侧壁并与研磨的软骨和生物相容性载体混合物接触 允许细胞转移到整个缺陷区域。 还公开了将成形的同种异体移植物结构插入软骨缺损区域的方法。
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公开(公告)号：US20090069901A1
公开(公告)日：2009-03-12
申请号：US12179034
申请日：2008-07-24
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30062 , A61F2002/30136 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30299 , A61F2002/30327 , A61F2002/30764 , A61F2002/30785 , A61F2210/0004 , A61F2230/0004 , A61F2230/0069 , A61F2230/0093 , A61F2250/0014 , A61F2250/0039 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3852 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
摘要翻译： 本发明涉及一种软骨修复组件，其包括软骨下骨的成形同种异体移植结构，其具有整体的上覆软骨帽，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和铣碎的同种异体移植软骨。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得成形骨或软骨盖以过盈配合接合钻孔的侧壁并与研磨的软骨和生物相容性载体混合物接触 允许细胞转移到整个缺陷区域。 还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。
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3.发明申请公开(公告)号：US20110196508A1
公开(公告)日：2011-08-11
申请号：US13025722
申请日：2011-02-11
IPC分类号： A61F2/02
CPC分类号： A61F2/28 , A61B17/00491 , A61F2/30744 , A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2002/2817 , A61F2002/2867 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30759 , A61F2002/30764 , A61F2210/0004 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61K35/28 , A61K35/32 , A61K38/18 , A61K38/28 , A61L27/20 , A61L27/24 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3852 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/06 , A61K2300/00 , C08L5/08
摘要： The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.
摘要翻译： 本发明涉及一种无菌软骨缺损植入物材料，其包含在生物可吸收载体中的尺寸范围为0.01mm至1.0mm的经研磨的冻干同种异体移植软骨片，其取自透明质酸钠，透明质酸及其衍生物，明胶，胶原，壳聚糖 ，藻酸盐，缓冲PBS，葡聚糖或以2.5×10 5至2.5×10 7的量加入同种异体移植软骨细胞的混合聚合物。
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公开(公告)号：USRE42208E1
公开(公告)日：2011-03-08
申请号：US12147042
申请日：2008-06-26
IPC分类号： A61K35/32
CPC分类号： A61F2/28 , A61B17/00491 , A61F2/30744 , A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2002/2817 , A61F2002/2867 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30759 , A61F2002/30764 , A61F2210/0004 , A61F2230/0069 , A61F2310/00365 , A61F2310/00383 , A61K35/28 , A61K35/32 , A61K38/18 , A61K38/28 , A61L27/20 , A61L27/24 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3852 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/06 , A61K2300/00 , C08L5/08
摘要： The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.
摘要翻译： 本发明涉及一种无菌软骨缺损植入物材料，其包含在生物可吸收载体中的尺寸范围为0.01mm至1.0mm的经研磨的冻干同种异体移植软骨片，其取自透明质酸钠，透明质酸及其衍生物，明胶，胶原，壳聚糖 ，藻酸盐，缓冲的PBS，葡聚糖或具有同种异体软骨细胞或骨髓细胞的聚合物，其数量超过透明软骨中自然发生的量，并加入细胞生长添加剂。
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公开(公告)号：US08221500B2
公开(公告)日：2012-07-17
申请号：US12179034
申请日：2008-07-24
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30062 , A61F2002/30136 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30299 , A61F2002/30327 , A61F2002/30764 , A61F2002/30785 , A61F2210/0004 , A61F2230/0004 , A61F2230/0069 , A61F2230/0093 , A61F2250/0014 , A61F2250/0039 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3821 , A61L27/3852 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
摘要翻译： 本发明涉及一种软骨修复组件，其包括软骨下骨的成形同种异体移植结构，其具有整体的上覆软骨帽，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和铣碎的同种异体移植软骨。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得成形骨或软骨盖以过盈配合接合钻孔的侧壁并与研磨的软骨和生物相容性载体混合物接触 允许细胞转移到整个缺陷区域。 还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。
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公开(公告)号：US20110060412A1
公开(公告)日：2011-03-10
申请号：US12875829
申请日：2010-09-03
申请人： Eric J. Semler , Arthur A. Gertzman , Yen-Chen Huang , Judith Yannariello-Brown , Katherine Gomes Truncale
发明人： Eric J. Semler , Arthur A. Gertzman , Yen-Chen Huang , Judith Yannariello-Brown , Katherine Gomes Truncale
CPC分类号： A61L27/3616 , A61F2/30756 , A61F2/3872 , A61F2002/30762 , A61K35/32 , A61K38/1841 , A61L27/225 , A61L27/3612 , A61L27/3654 , A61L27/38 , A61L27/3817 , A61L27/48 , A61L2430/06 , A61K2300/00
摘要： A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.
摘要翻译： 提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。 当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。 修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。
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公开(公告)号：US08883210B1
公开(公告)日：2014-11-11
申请号：US13108856
申请日：2011-05-16
申请人： Katherine Gomes Truncale , Arthur A. Gertzman , Yen-Chen Huang , Eric Semler , Evangelia Chnari , Anouska Dasgupta , Judith Yannariello-Brown , Terri Riley
发明人： Katherine Gomes Truncale , Arthur A. Gertzman , Yen-Chen Huang , Eric Semler , Evangelia Chnari , Anouska Dasgupta , Judith Yannariello-Brown , Terri Riley
CPC分类号： C12N5/0654 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/19 , C12N5/0605 , C12N5/0653 , C12N5/0667 , C12N5/0668 , C12N2501/155 , C12N2533/90 , A61K2300/00
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.
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公开(公告)号：US20110059178A1
公开(公告)日：2011-03-10
申请号：US12875733
申请日：2010-09-03
申请人： Eric J. Semler , Arthur A. Gertzman , Yen-Chen Huang , Judith Yannariello-Brown , Katherine Gomes Truncale
发明人： Eric J. Semler , Arthur A. Gertzman , Yen-Chen Huang , Judith Yannariello-Brown , Katherine Gomes Truncale
CPC分类号： A61L27/3654 , A61F2/3872 , A61K35/32 , A61K35/34 , A61L27/3612 , A61L27/3834 , A61L27/48 , A61L2430/06
摘要： A meniscus repair composition for application to a meniscus defect site to promote growth of new tissue at the meniscus defect site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 μm to about 500 μm; a carrier selected from the group consisting of sodium hyaluronate, gelatin, collagen, polyethylene glycol, glycerin, carboxymethylcellulose, dextrose, blood derivatives, aqueous solutions thereof, and mixtures thereof; and a curing agent. The curing agent may be the carrier where the carrier is cross-linkable. When introduced to a defect site in a meniscus and cured, the composition will not flow away from the defect site, and the composition is non-adhering to the defect site after it is cured.
摘要翻译： 提供了一种应用于弯液面缺陷部位以促进新生组织在弯液面缺陷部位生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 选自透明质酸钠，明胶，胶原，聚乙二醇，甘油，羧甲基纤维素，葡萄糖，血液衍生物，其水溶液及其混合物的载体; 和固化剂。 固化剂可以是载体可交联的载体。 当引入弯液面中的缺陷部位并固化时，组合物不会从缺陷部位流出，并且组合物在固化后不粘附到缺陷部位。
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9.发明授权公开(公告)号：US08435551B2
公开(公告)日：2013-05-07
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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10.发明申请公开(公告)号：US20100015202A1
公开(公告)日：2010-01-21
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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