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公开(公告)号：US20080300232A1
公开(公告)日：2008-12-04
申请号：US10599110
申请日：2005-03-21
申请人： Kay Brickmann , Bryan J. Egner , Fabrizio Giordanetto , Tord Inghardt , Anna Linusson Jonsson , Fritiof Ponten
发明人： Kay Brickmann , Bryan J. Egner , Fabrizio Giordanetto , Tord Inghardt , Anna Linusson Jonsson , Fritiof Ponten
IPC分类号： A61K31/397 , C07D401/02 , A61K31/454 , C07D213/02 , A61P3/04 , A61P3/10 , A61P25/00 , A61K31/4545 , C07D239/24 , A61K31/506
CPC分类号： C07D403/06 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14
摘要： Compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders and to pharmaceutical compositions containing them.
摘要翻译： 式I化合物，制备这些化合物的方法，它们在治疗肥胖，精神障碍，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症中的用途，以及神经障碍如痴呆，多发性硬化，帕金森病，亨廷顿病 舞蹈病和阿尔茨海默病和疼痛相关疾病以及含有它们的药物组合物。
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公开(公告)号：US07723331B2
公开(公告)日：2010-05-25
申请号：US11840382
申请日：2007-08-17
IPC分类号： C07D495/04 , C07D413/14 , A61K31/5355 , A61K31/519 , A61P3/04 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D495/04
摘要： The present invention provides compounds of the class of thienopyrimidines, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, type II diabetes, Metabolic syndrome and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, and pain related disorders, and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供噻吩并嘧啶类化合物，制备这些化合物的方法，其用于治疗肥胖症，精神疾病，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症，II型糖尿病，代谢综合征和神经系统疾病 障碍，例如痴呆，多发性硬化，帕金森病，亨廷顿氏舞蹈病，阿尔茨海默病和疼痛相关疾病，以及含有它们的药物组合物。
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公开(公告)号：US20080306055A1
公开(公告)日：2008-12-11
申请号：US11721767
申请日：2005-12-19
申请人： Bryan Egner , Fabrizio Giordanetto , Tord Inghardt
发明人： Bryan Egner , Fabrizio Giordanetto , Tord Inghardt
IPC分类号： A61K31/541 , A61K31/454 , C07D401/02 , A61K31/4545 , A61P25/00 , A61P3/10 , A61P25/18 , C07D401/14 , C07D417/14
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula I depicted below, pharmaceutical compositions containing them, processes for preparing the compounds, and their use in the treatment of obesity, type II diabetes, metabolic syndrome, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy and related conditions, neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease, and pain related disorders. The compounds are melanin concentrating hormone receptor 1 (MCHr1) antagonists.
摘要翻译： 下面描述的式I化合物，含有它们的药物组合物，制备化合物的方法及其在治疗肥胖症，II型糖尿病，代谢综合征，精神病学，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症中的用途， 神经系统疾病如痴呆，多发性硬化，帕金森病，亨廷顿舞蹈病和阿尔茨海默病，以及疼痛相关疾病。 这些化合物是黑色素浓缩激素受体1（MCHr1）拮抗剂。
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公开(公告)号：US20070185079A1
公开(公告)日：2007-08-09
申请号：US10596994
申请日：2005-01-05
IPC分类号： A61K31/554
CPC分类号： C07D215/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.
摘要翻译： 式（I）化合物，制备这些化合物的方法，它们在治疗肥胖症，精神疾病，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症中的用途，以及神经系统疾病如痴呆，多发性硬化，帕金森病 ，亨廷顿氏舞蹈病和阿尔茨海默病和疼痛相关疾病，以及含有它们的药物组合物。
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公开(公告)号：US20080221107A1
公开(公告)日：2008-09-11
申请号：US11995570
申请日：2006-07-13
IPC分类号： A61K31/53 , C07D513/04 , A61K31/519 , A61K31/5025 , A61P3/10 , A61P3/04 , A61P25/00
CPC分类号： C07D495/04
摘要： Compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders and to pharmaceutical compositions containing them.
摘要翻译： 式（I）化合物，制备这些化合物的方法，它们在治疗肥胖症，精神疾病，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症中的用途，以及神经系统疾病如痴呆，多发性硬化，帕金森病 ，亨廷顿氏舞蹈病和阿尔茨海默病和疼痛相关疾病以及含有它们的药物组合物。
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公开(公告)号：US20080051405A1
公开(公告)日：2008-02-28
申请号：US11840382
申请日：2007-08-17
IPC分类号： C07D495/04 , A61K31/5025 , A61K31/519 , A61P25/00 , A61P3/00
CPC分类号： C07D495/04
摘要： The present invention provides compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, type II diabetes, Metabolic syndrome and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, and pain related disorders, and to pharmaceutical compositions containing them.
摘要翻译： 本发明提供了式I化合物，其制备方法，用于治疗肥胖症，精神疾病，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症，II型糖尿病，代谢综合征和神经障碍 作为痴呆，多发性硬化，帕金森病，亨廷顿氏舞蹈病，阿尔茨海默病和疼痛相关疾病，以及含有它们的药物组合物。
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公开(公告)号：US07803954B2
公开(公告)日：2010-09-28
申请号：US11520063
申请日：2006-09-13
申请人： Tord Inghardt
发明人： Tord Inghardt
IPC分类号： C07D205/00
CPC分类号： C07D401/12 , A61K31/397 , C07C37/055 , C07C41/16 , C07C41/26 , C07C41/30 , C07C45/004 , C07C45/29 , C07C45/45 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C49/84 , C07C59/50 , C07C59/56 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/738 , C07C205/59 , C07D205/04 , C07D207/16 , C07D263/58 , C07D403/12 , C07C43/23 , C07C43/225 , C07C39/27
摘要： There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.
摘要翻译： 提供式（I）化合物，其中R a，R 1，R 2，Y和R 3具有本说明书中给出的含义及其药学上可接受的衍生物（包括前药）），该化合物和衍生物可用作或可用作前药 的胰蛋白酶样蛋白酶（例如凝血酶）的竞争性抑制剂，因此特别是在治疗需要凝血酶抑制（例如血栓形成）或作为抗凝剂的条件下。
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公开(公告)号：US07645751B2
公开(公告)日：2010-01-12
申请号：US11797656
申请日：2007-05-04
申请人： Tord Inghardt
发明人： Tord Inghardt
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D401/12 , A61K31/397 , C07C37/055 , C07C41/16 , C07C41/26 , C07C41/30 , C07C45/004 , C07C45/29 , C07C45/45 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C49/84 , C07C59/50 , C07C59/56 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/738 , C07C205/59 , C07D205/04 , C07D207/16 , C07D263/58 , C07D403/12 , C07C43/23 , C07C43/225 , C07C39/27
摘要： There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.
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9.发明申请公开(公告)号：US20070099962A1
公开(公告)日：2007-05-03
申请号：US10596506
申请日：2004-12-15
申请人： Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo
发明人： Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo
IPC分类号： C07D401/02 , C07D213/63 , C07D213/84 , A61K31/4439 , A61K31/4412
CPC分类号： C07D211/98
摘要： There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as trombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of trombin is required or desired, and/or conditions whereas anticoagulant therapy is indicated).
摘要翻译： 提供了式（I）的化合物，其中R 1，R 2，R 2，R 2b，R 3a， R 3b，R 4，R 5，R 6，A，G和L具有以下含义： 描述，哪些化合物可用作或可用作胰蛋白酶样蛋白酶的竞争性抑制剂诸如凝血酶的前药，因此特别是在治疗凝血酶抑制有益的条件（例如条件，例如 作为血栓栓塞，其中需要或期望凝血酶的抑制，和/或表示抗凝治疗的条件）。
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公开(公告)号：US06630600B1
公开(公告)日：2003-10-07
申请号：US09341931
申请日：1999-07-20
申请人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Lindstedt Alstermark
发明人： Kjell Andersson , Maria Boije , Johan Gottfries , Tord Inghardt , Lanna Li , Eva-Lotte Lindstedt Alstermark
IPC分类号： C07C6976
CPC分类号： C07C233/25 , C07B2200/07 , C07C217/76 , C07C233/29 , C07C233/75 , C07C235/42 , C07C255/54 , C07C271/28 , C07C271/38 , C07C271/44 , C07C271/58 , C07C275/34 , C07C309/65 , C07C309/66 , C07C309/73 , C07C311/08 , C07C311/13 , C07C311/16 , C07C317/22 , C07C317/28 , C07C323/19 , C07C323/44 , C07C323/56 , C07C335/18 , C07C2601/14
摘要： Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.
摘要翻译： 新型3-芳基丙酸衍生物及其类似物，其制备方法和中间体，含有它们的药物制剂以及该化合物在与胰岛素抵抗相关的临床病症中的用途。
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