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13 条记录 (耗时 0.022 秒)

    Latex particles and process for producing the same
    3.
    发明申请
    Latex particles and process for producing the same 审中-公开
    乳胶颗粒及其制造方法

    公开(公告)号：US20060100367A1

    公开(公告)日：2006-05-11

    申请号：US10539732

    申请日：2003-12-19

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Tadahito Takahashi ,  Hidenori Otsuka ,  Noriyuki Ito ,  Kouichiro Ishigaki

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Tadahito Takahashi ,  Hidenori Otsuka ,  Noriyuki Ito ,  Kouichiro Ishigaki

    IPC分类号： C08K5/5333 ,  C08F218/08

    CPC分类号： C08F220/28 ,  C08F283/06 ,  C08F290/00

    摘要： This invention provides latex particles wherein non-specific adsorption or binding of undesired impurities which usually accompanies the use of latex particles is inhibited, and a process to produce such latex particles. This invention also provides diagnostic agent which contains said particles. In another embodiment, this invention provides latex particles comprising both a ligand group-holding site which has a ligand group on the one terminal and is bound, on the other terminal, to latex particles, and which has a long chain of polyoxyethylene; and a non-specific adsorption-inhibiting site which is bound, at one terminal, to latex particles, and which has a short chain of polyoxyethylene. In this embodiment, this invention also provides a process to produce said particles.

    摘要翻译： 本发明提供胶乳颗粒，其中通常伴随使用胶乳颗粒的非特异性吸附或不希望的杂质的结合被抑制，以及制备这种胶乳颗粒的方法。 本发明还提供含有所述颗粒的诊断剂。 在另一个实施方案中，本发明提供了胶乳颗粒，其包含在一个末端具有配体基团并且在另一个末端上结合的配体基团保持位点与胶乳颗粒并且具有长链聚氧乙烯的胶乳颗粒; 和非特异性吸附抑制位点，其在一个末端与胶乳颗粒结合，并具有短链的聚氧乙烯。 在该实施方案中，本发明还提供了生产所述颗粒的方法。

    Method of high-speed detection for biological analyte
    4.
    发明申请
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US20070059843A1

    公开(公告)日：2007-03-15

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。

    Method of high-speed detection for biological analyte
    7.
    发明授权
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US07732158B2

    公开(公告)日：2010-06-08

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/53 ,  G01N33/553 ,  G01N33/544 ,  G01N33/547 ,  G01N33/537

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。