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公开(公告)号:US5483846A
公开(公告)日:1996-01-16
申请号:US143882
申请日:1993-11-01
摘要: An impact sensing apparatus includes a container, a weight swingably supported in the container and which is swung by an impact exceeding a predetermined value, an output member rotatably supported in the container and which engages the weight, the output member disengages the weight by the swing movement of the weight. A spring member is disposed between the container and the output member, which biases the output member so as to be rotated, and urges the weight so as not to swing. The weight includes a stopper portion for contacting the container so as to hold the weight at an initial position. The stopper portion is disposed at an outside edge of the weight and spaced from the pivotal axis of the weight so that the spring member presses against the container in an upwardly direction substantially vertical to a surface of the container.
摘要翻译: 冲击感测装置包括容器,可摆动地支撑在容器中并通过超过预定值的冲击摆动的重物;可旋转地支撑在容器中并与重物接合的输出构件,输出构件使重量脱离摆动 运动的重量。 弹簧构件设置在容器和输出构件之间,其偏压输出构件以便旋转,并且促使重物不摆动。 重量包括用于使容器接触以将重量保持在初始位置的止动部分。 止动部分设置在重物的外边缘并且与重物的枢转轴线间隔开,使得弹簧构件在基本垂直于容器表面的向上方向上压靠容器。
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公开(公告)号:US5357816A
公开(公告)日:1994-10-25
申请号:US14248
申请日:1993-02-05
CPC分类号: B60R21/33 , G01P15/036 , Y10T74/11
摘要: An impact sensing apparatus includes a housing having a wall portion which is parallel with the applied direction of an outside shock and a hole which is formed in the wall portion, a weight disposed in the housing and moved by an outside shock which is more than a predetermined value, an output member rotatably disposed in the housing and rotated in response to the movement of the weight and an urging member interposed between the housing and the output member for urging the output member so as to project from the hole. According to this improved impact sensing apparatus, it is possible to lengthen the stroke of the rotational motion of the output member and therefore it is possible to effectively utilize the urging force of the urging member as a kinetic energy of the output member. Thus, it is possible to improve the reliability for igniting the ignition element such as a primer due to a striking operation of the output member.
摘要翻译: 冲击感测装置包括壳体,该壳体具有与外部冲击的施加方向平行的壁部和形成在壁部中的孔,设置在壳体中并由外部冲击移动的重物, 预定值,可旋转地设置在壳体中并且响应于重物的移动而旋转的输出构件和插入壳体和输出构件之间的推动构件,用于推压输出构件以从孔突出。 根据该改进的冲击感测装置,可以延长输出部件的旋转运动的行程,因此能够有效地利用推动部件的作用力作为输出部件的动能。 因此,可以提高由于输出构件的打击操作而引燃诸如底漆的点火元件的可靠性。
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公开(公告)号:US5193407A
公开(公告)日:1993-03-16
申请号:US802530
申请日:1991-12-05
摘要: A hole 13 though which a firing pin 6a of a firing lever 6 is projected outside a housing 1 is formed in a wall 1c of the housing which is in parallel with a direction of an external shock applied to the housing 1. This structure ensures the rotational angle of the firing lever 6 and a biasing force of a spring 9 which urges the firing lever 6 can be used effectively as kinetic energy thereof.
摘要翻译: 在外壳1的壁1c上形成有与外壳1的外部冲击方向平行的孔13,通过该孔13将击发杆6的击发销6a突出到外壳1的外侧。 击发杆6的旋转角度和推动击发杆6的弹簧9的作用力能够被有效地用作其动能。
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公开(公告)号:US5769471A
公开(公告)日:1998-06-23
申请号:US706939
申请日:1996-09-03
申请人: Yasuaki Suzuki , Naofumi Fujie , Toshimitsu Oka , Kazunori Sakamoto , Kouji Aoki , Osamu Fujimoto , Yutaka Kondoh , Masahiro Miyaji
发明人: Yasuaki Suzuki , Naofumi Fujie , Toshimitsu Oka , Kazunori Sakamoto , Kouji Aoki , Osamu Fujimoto , Yutaka Kondoh , Masahiro Miyaji
CPC分类号: E05B77/12 , E05B85/13 , Y10S292/22 , Y10T292/1047 , Y10T292/57
摘要: An apparatus for unlocking a door lock for a vehicle, comprising a plurality of door locks for being mounted on doors of the vehicle, a collision direction detecting device for detecting a direction of an impact applied to a vehicle; and an unlocking mechanism for unlocking a door lock located on a side opposite to a collision side based on the direction detected by the collision direction detecting device.
摘要翻译: 一种用于解锁用于车辆的门锁的装置,包括用于安装在车门上的多个门锁,用于检测施加到车辆的冲击方向的碰撞方向检测装置; 以及解锁机构,用于基于由碰撞方向检测装置检测到的方向来解锁位于与碰撞侧相反的一侧的门锁。
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公开(公告)号:US5454322A
公开(公告)日:1995-10-03
申请号:US17299
申请日:1993-02-12
申请人: Kazunori Sakamoto , Masanobu Ishikawa , Koji Ito , Yutaka Kondoh
发明人: Kazunori Sakamoto , Masanobu Ishikawa , Koji Ito , Yutaka Kondoh
CPC分类号: B60R21/33
摘要: A shock detecting device includes a housing, a weight disposed in the housing and moved by a shock which is more than a predetermined value from outside, an output member rotatably disposed in the housing and rotated in response to the movement of the weight so as to be projected from the housing and a safety mechanism being provided with a stopper pin which is formed on the weight and which contacts with the housing in an initial condition in order to maintain the weight in the initial condition, a rock lever which is rotatably supported on the housing and which being able to engage or disengage with or from the stopper pin and a first urging device which is disposed between the rock lever and the housing always for urging the rock lever so as to be engaged the rock lever with the stopper pin. According to this improved shock detecting device, it is able to maintain the high reliability of the safety mechanism with a simple structure.
摘要翻译: 一种冲击检测装置,包括壳体,设置在壳体中并且受到来自外部的超过预定值的冲击而移动的重物,可旋转地设置在壳体中并响应于重物的运动而旋转的输出构件, 从壳体突出并设置有安全机构,该止动销形成在重物上并且在初始状态下与壳体接触以便将重量保持在初始状态,摇杆被可旋转地支撑在 所述壳体能够与所述止动销接合或脱离,以及设置在所述摇杆和所述壳体之间的第一推动装置,其总是用于推动所述摇杆,以使所述摇杆与所述止动销接合。 根据这种改进的冲击检测装置,能够以简单的结构保持安全机构的高可靠性。
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公开(公告)号:US20120184521A1
公开(公告)日:2012-07-19
申请号:US13498159
申请日:2010-09-24
申请人: Eiji Kawaminami , Tatsuhisa Takahashi , Takatoshi Kanayama , Yuta Fukuda , Hiroyuki Kaizawa , Yutaka Kondoh , Ryushi Seo , Kazuyuki Kuramoto , Kazuhiko Take , Kazuyuki Sakamoto
发明人: Eiji Kawaminami , Tatsuhisa Takahashi , Takatoshi Kanayama , Yuta Fukuda , Hiroyuki Kaizawa , Yutaka Kondoh , Ryushi Seo , Kazuyuki Kuramoto , Kazuhiko Take , Kazuyuki Sakamoto
IPC分类号: A61K31/426 , C07D417/12 , A61K31/427 , A61K31/496 , A61P43/00 , A61K31/513 , A61K31/538 , A61K31/454 , A61K31/541 , C07D277/56 , A61K31/4439
CPC分类号: A61K31/426 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/415 , A61K31/42 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/4965 , C07D207/34 , C07D213/81 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D417/12
摘要: A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.
摘要翻译: 取代的酰胺化合物可用作药物组合物的活性成分,特别是用于治疗由溶血磷脂酸(LPA)引起的疾病的药物组合物。 该化合物具有下式:在该式中,A是任选取代的芳基等; B是任选取代的5元芳族杂环基团; X是单键或 - (CRX1RX2)n-; n为1,2,3或4; RX1和RX2是氢等; Y1〜Y5分别为CRY或N; 每个RY是氢等; R1和R2是氢等; m为1,2或3; R3是氢等; 并且R 4是任选取代的低级烷基等。
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公开(公告)号:US20100099658A1
公开(公告)日:2010-04-22
申请号:US12448759
申请日:2008-07-04
申请人: Yutaka Kondoh , Kazuhiko Iikubo , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani , Itsuro Shimada , Takahiro Matsuya , Kazuo Kurosawa , Akio Kamikawa , Hiroyuki Mano
发明人: Yutaka Kondoh , Kazuhiko Iikubo , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani , Itsuro Shimada , Takahiro Matsuya , Kazuo Kurosawa , Akio Kamikawa , Hiroyuki Mano
IPC分类号: A61K31/397 , C07D239/72 , A61K31/497 , A61K31/517 , C07D413/02 , A61K31/5377 , C07D403/02 , A61K31/53 , C07D279/12 , A61K31/541 , A61P35/00
CPC分类号: A61K31/551 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D239/95 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/70 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/113 , C07D498/10
摘要: The present invention provides a compound which is useful as an inhibitor against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins.As a result of extensive and intensive studies on compounds having an inhibitory effect against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins, the inventors of the present invention have found that the di(arylamino)aryl compound of the present invention has inhibitory activity against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. This finding led to the completion of the present invention. The compound of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, lung cancer, non-small cell lung cancer, small cell lung cancer, EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive cancer, EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive lung cancer, or EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive non-small cell lung cancer, etc.
摘要翻译: 本发明提供了可用作抑制EML4-ALK融合蛋白和突变型EGFR蛋白的激酶活性的化合物。 作为对具有对EML4-ALK融合蛋白和突变型EGFR蛋白的激酶活性具有抑制作用的化合物的广泛和深入研究的结果,本发明的发明人已经发现本发明的二(芳基氨基)芳基化合物具有 对EML4-ALK融合蛋白和突变型EGFR蛋白激酶活性的抑制活性。 这一发现导致了本发明的完成。 本发明的化合物可以用作预防和/或治疗癌症,肺癌,非小细胞肺癌,小细胞肺癌,EML4-ALK融合多核苷酸阳性和/或突变型EGFR多核苷酸的药物组合物, 阳性癌症,EML4-ALK融合多核苷酸阳性和/或突变型EGFR多核苷酸阳性肺癌或EML4-ALK融合多核苷酸阳性和/或突变型EGFR多核苷酸阳性非小细胞肺癌等。
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公开(公告)号:US20120040968A1
公开(公告)日:2012-02-16
申请号:US13266164
申请日:2010-05-06
申请人: Itsuro Shimada , Kazuo Kurosawa , Takahiro Matsuya , Kazuhiko Iikubo , Yutaka Kondoh , Akio Kamikawa , Hiroshi Tomiyama , Yoshinori Iwai
发明人: Itsuro Shimada , Kazuo Kurosawa , Takahiro Matsuya , Kazuhiko Iikubo , Yutaka Kondoh , Akio Kamikawa , Hiroshi Tomiyama , Yoshinori Iwai
IPC分类号: A61K31/497 , C07D405/14 , C07D401/14 , C07D491/113 , C07D403/12 , A61K31/551 , A61K31/538 , C07D409/14 , C07D417/12 , A61K31/55 , A61K31/541 , C07D471/08 , C07D241/28 , C07D401/12 , A61K31/513 , C07D239/48 , A61P35/00 , A61K31/5377
CPC分类号: C07D239/48 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D491/113
摘要: Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein.As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.
摘要翻译: 提供了可用作抑制EML4-ALK融合蛋白的激酶活性的化合物。 作为对具有针对EML4-ALK融合蛋白的激酶活性的抑制活性的化合物进行了深入和广泛的研究的结果,本发明人发现本发明的二氨基杂环羧酰胺化合物对EML4-ALK融合体的激酶活性具有抑制活性 蛋白。 通过这一发现,完成了本发明。 本发明的化合物可以用作预防和/或治疗癌症的药物组合物,例如肺癌,非小细胞肺癌和小细胞肺癌。
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公开(公告)号:US5541182A
公开(公告)日:1996-07-30
申请号:US391835
申请日:1995-02-16
申请人: Masato Satoh , Yutaka Kondoh , Yoshinori Okamoto , Akito Nishida , Kazuo Honda , Masayuki Saito
发明人: Masato Satoh , Yutaka Kondoh , Yoshinori Okamoto , Akito Nishida , Kazuo Honda , Masayuki Saito
IPC分类号: A61K31/55 , B65D25/52 , B65D83/08 , B65H35/10 , C07D243/24 , C07D243/26 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/06
CPC分类号: C07D401/06 , B65D83/0847 , B65H35/10 , C07D243/24 , C07D403/04 , C07D409/06 , B65H2701/11231
摘要: This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted), to medicinal compositions comprising the same, and to a process for producing the same. The compounds of formula (I) shown above exhibit antagonism for the CCK-B receptor and the action of depressing the gastric acid secretion caused by the stimulus of pentagastrin, and are therefore useful as a drug for the relief of diseases related to the CCK-B receptor and the gastrin receptor.
摘要翻译: 本发明涉及由以下通式(I)表示的新型苯并二氮杂衍生物或其药学上可接受的盐,其中R 1为芳基或5元单环,6元环的芳族杂环基 单环或5-和6-元双环结构,其可任选被取代;和R 2是可任选被取代的芳基),包含它们的药用组合物及其制备方法。 上述式(I)的化合物对CCK-B受体表现出拮抗作用,并且抑制由五肽胃泌素刺激引起的胃酸分泌的作用,因此可用作缓解与CCK- B受体和胃泌素受体。
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公开(公告)号:US20130197009A1
公开(公告)日:2013-08-01
申请号:US13877358
申请日:2011-10-21
申请人: Yukitaka Ideyama , Sadao Kuromitsu , Takashi Furutani , Masayoshi Takeda , Satoshi Konagai , Tomohiro Yamada , Nobuaki Taniguchi , Yutaka Kondoh , Masaaki Hirano , Kazushi Watanabe , Takashi Sugane , Akio Kakefuda
发明人: Yukitaka Ideyama , Sadao Kuromitsu , Takashi Furutani , Masayoshi Takeda , Satoshi Konagai , Tomohiro Yamada , Nobuaki Taniguchi , Yutaka Kondoh , Masaaki Hirano , Kazushi Watanabe , Takashi Sugane , Akio Kakefuda
IPC分类号: C07D401/02 , C07D401/14 , C07D403/02
CPC分类号: C07D401/02 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/12
摘要: [Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation[Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.
摘要翻译: 本发明的目的在于提供一种可用于治疗伴随雄激素受体突变的前列腺癌的新型抗癌药物。本发明人进行了关于雄激素相关疾病的全面研究, 雄激素药物变得无效。 结果发现,作为本发明的药物组合物的活性成分的化合物在人突变型雄激素受体(AR)中表现出对转录活化的抑制作用,并且在人体中具有优异的抗肿瘤作用 前列腺癌的小鼠,从而完成本发明。 因此,作为本发明的药物组合物的活性成分的化合物可用于一系列与前列腺癌有关的雄激素受体相关疾病。
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