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1.发明授权公开(公告)号：US08263004B2
公开(公告)日：2012-09-11
申请号：US10545429
申请日：2004-02-13
申请人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
发明人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
IPC分类号： A61L2/00 , A61L101/00
CPC分类号： A61L2/0011 , A61L2/14 , A61L9/22
摘要： The present invention relates to a method of deactivating an antigenic substance by causing positive and negative ions to act on the antigenic substance, and the positive and negative ions are caused to act in an atmosphere in which each of positive ion concentration and negative ion concentration is at least about 50,000/cm3, and more preferably, at least about 100,000/cm3.
摘要翻译： 本发明涉及通过使正离子和负离子作用于抗原性物质而使抗原性物质失活的方法，使正离子和负离子在其中正离子浓度和负离子浓度分别为 至少约50,000 / cm3，更优选至少约100,000 / cm3。
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2.发明授权公开(公告)号：US08420326B2
公开(公告)日：2013-04-16
申请号：US10545239
申请日：2004-02-13
申请人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
发明人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
IPC分类号： G01N33/53
CPC分类号： G01N33/53
摘要： A method of evaluating performance of an activation gas deactivating an antigenic substance including the steps of causing the antigenic substance and the activation gas to react with each other, to obtain a processed antigenic substance, and causing an antibody against the antigenic substance with the processed antigenic substance to measure binding activity of the processed antigenic substance with the antibody is provided, whereby an evaluation method that can accurately and easily evaluate performance of an activation gas deactivating an antigenic substance is provided.
摘要翻译： 一种评估活化气体的活性气体的性能的方法，包括使所述抗原物质和活化气体彼此反应的步骤，以获得加工过的抗原物质，并使所述抗原物质的抗体与经处理的抗原性 提供了测定加工抗原物质与抗体的结合活性的物质，由此提供了能够准确且容易地评价使抗原性物质失活的活化气体的性能的评价方法。
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3.发明申请公开(公告)号：US20070199815A1
公开(公告)日：2007-08-30
申请号：US10545429
申请日：2004-02-13
申请人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
发明人： Kazuo Nishikawa , Hideo Nojima , Tetsuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
IPC分类号： B01D49/00
CPC分类号： A61L2/0011 , A61L2/14 , A61L9/22
摘要： The present invention relates to a method of deactivating an antigenic substance by causing positive and negative ions to act on the antigenic substance, and the positive and negative ions are caused to act in an atmosphere in which each of positive ion concentration and negative ion concentration is at least about 50,000/cm3, and more preferably, at least about 100,000/cm3.
摘要翻译： 本发明涉及通过使正离子和负离子作用于抗原性物质而使抗原性物质失活的方法，使正离子和负离子在其中正离子浓度和负离子浓度分别为 至少约50,000 / cm 3，更优选至少约100,000 / cm 3。
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4.发明申请公开(公告)号：US20070264192A1
公开(公告)日：2007-11-15
申请号：US10545239
申请日：2004-02-13
申请人： Kazuo Nishikawa , Hideo Nojima , Tesuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
发明人： Kazuo Nishikawa , Hideo Nojima , Tesuya Yoneda , Kazuhisa Ono , Seiko Shigeta , Masatoshi Oshita
CPC分类号： G01N33/53
摘要： A method of evaluating performance of an activation gas deactivating an antigenic substance including the steps of causing the antigenic substance and the activation gas to react with each other, to obtain a processed antigenic substance, and causing an antibody against the antigenic substance with the processed antigenic substance to measure binding activity of the processed antigenic substance with the antibody is provided, whereby an evaluation method that can accurately and easily evaluate performance of an activation gas deactivating an antigenic substance is provided.
摘要翻译： 一种评估活化气体的活性气体的性能的方法，包括使所述抗原物质和活化气体彼此反应的步骤，以获得加工过的抗原物质，并使所述抗原物质的抗体与经处理的抗原性 提供了测定加工抗原物质与抗体的结合活性的物质，由此提供了能够准确且容易地评价使抗原性物质失活的活化气体的性能的评价方法。
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5.发明申请公开(公告)号：US20100196384A1
公开(公告)日：2010-08-05
申请号：US12762649
申请日：2010-04-19
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
IPC分类号： A61K39/395 , C07K16/18 , C12N5/07 , G01N33/53 , A61P37/06
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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6.发明授权Method for producing highly unsaturated fatty acids and lipid containing same 有权生产高度不饱和脂肪酸的方法和含有它的脂质公开(公告)号：US06958229B2
公开(公告)日：2005-10-25
申请号：US09389318
申请日：1999-09-03
申请人： Osamu Suzuki , Kazuhisa Ono , Seiko Shigeta , Tsunehiro Aki , Kengo Akimoto
发明人： Osamu Suzuki , Kazuhisa Ono , Seiko Shigeta , Tsunehiro Aki , Kengo Akimoto
CPC分类号： C12P7/6427 , A23K10/16 , A23K20/158 , C12P7/6472
摘要： A method for producing highly unsaturated fatty acids comprising culturing a microorganism, belonging to the genus Mortierella and having resistance to a carbon source, in a medium having a carbon source concentration of at least 4% by weight, and collecting highly unsaturated fatty acids from the cultured products. Culturing the microorganism for about a week gives at least about 7 g/L of highly unsaturated fatty acids.
摘要翻译： 一种生产高度不饱和脂肪酸的方法，包括在碳源浓度至少为4％（重量）的培养基中培养属于被孢霉属（Mortierella）的微生物并具有耐碳源性的微生物，并从 培养产品。 将微生物培养约一周，得到至少约7g / L的高度不饱和脂肪酸。
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7.发明授权Anti-histone H1 monoclonal antibody and hybridoma for the production thereof 有权抗组蛋白H1单克隆抗体和用于其生产的杂交瘤公开(公告)号：US08187602B2
公开(公告)日：2012-05-29
申请号：US12762649
申请日：2010-04-19
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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公开(公告)号：US07964554B2
公开(公告)日：2011-06-21
申请号：US11661763
申请日：2005-09-05
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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9.发明申请公开(公告)号：US20080287352A1
公开(公告)日：2008-11-20
申请号：US11661763
申请日：2005-09-05
申请人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
发明人： Takeshi Goto , Shuji Sato , Kazuhisa Ono , Seiko Shigeta , Seiji Kawamoto , Shigeru Goto
CPC分类号： C07K16/18 , C07K7/08 , C07K14/47 , Y10S530/808 , Y10S530/809
摘要： The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
摘要翻译： 本发明公开了用于抑制，预测或诊断器官移植移植排斥反应的抗组蛋白H1单克隆抗体，其生产用杂交瘤和多肽。
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公开(公告)号：US5747047A
公开(公告)日：1998-05-05
申请号：US293605
申请日：1994-08-22
申请人： Satoru Oka , Kazuhisa Ono , Seiko Shigeta , Takeshi Wada
发明人： Satoru Oka , Kazuhisa Ono , Seiko Shigeta , Takeshi Wada
IPC分类号： A61K39/35 , A61K38/00 , A61K49/00 , A61P37/08 , C07K14/00 , C07K14/435 , G01N33/48 , G01N33/53 , A61K39/36 , C07K1/00 , C07K16/00
CPC分类号： C07K14/43531 , A61K38/00
摘要： The present invention is directed to novel purified and isolated mite allergens possessing mite allergen activity with a molecular weight of about 94,000, about 40,000, about 16,000 or about 14,000 as determined by SDS-PAGE, which can be isolated from extracts of mite, and to a process for producing such mite allergens. The purified and isolated mites allergens of the present invention are useful as a pharmaceutical and a diagnostic composition for mite allergic diseases.
摘要翻译： 本发明涉及具有螨过敏原活性的新型纯化和分离的螨变应原，其分子量约为94,000，约40,000，约16,000或约14,000，通过SDS-PAGE测定，其可以从螨的提取物中分离，并且 一种生产这种螨变应原的方法。 本发明的纯化和分离的螨过敏原可用作螨过敏性疾病的药物和诊断组合物。
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