公开(公告)号：US06814995B1

公开(公告)日：2004-11-09

申请号：US10018793

申请日：2001-12-21

申请人： Kazuyoshi Sotoyama ,  Kazuyoshi Doi ,  Teruhiko Mizota ,  Yuzo Asano ,  Kiyotaka Takahashi ,  Tadahiro Abe

发明人： Kazuyoshi Sotoyama ,  Kazuyoshi Doi ,  Teruhiko Mizota ,  Yuzo Asano ,  Kiyotaka Takahashi ,  Tadahiro Abe

IPC分类号： A23C1900

CPC分类号： A23C19/093 ,  A23C19/08 ,  A23C19/082 ,  A23C19/084 ,  A23C20/00

摘要： This invention seeks to provide an all-purpose food material which can be mixed in various kinds of foods, specifically in a cheese-like food in large quantities without limitation. The food material is produced by subjecting a processed cheese-like food to heating and melting treatment at at least 120° C.

公开(公告)号：US06451344B1

公开(公告)日：2002-09-17

申请号：US09674247

申请日：2000-10-30

申请人： Kazuyoshi Sotoyama ,  Teruhiko Mizota ,  Yuzo Asano ,  Tetsushi Mori ,  Yuriko Iiyama

发明人： Kazuyoshi Sotoyama ,  Teruhiko Mizota ,  Yuzo Asano ,  Tetsushi Mori ,  Yuriko Iiyama

IPC分类号： A61K936

CPC分类号： A61K9/2826

摘要： This invention is a sugar coated tablet which has anticariogenic properties, containing no sucrose but a mixture of lactulose and raffinose with various physiological effects, as a sugar coat base, and these tablets comprises a core tablet and a sugar base coating the same, the sugar base contains the above mixture as the active ingredient.

摘要翻译： 本发明是一种糖衣片剂，其具有抗糖尿病性质，不含蔗糖，但是具有各种生理作用的乳果糖和棉子糖的混合物作为糖衣基质，并且这些片剂包含芯片和包衣它的糖基，糖 碱含有上述混合物作为活性成分。

公开(公告)号：US07032893B2

公开(公告)日：2006-04-25

申请号：US10433576

申请日：2001-11-15

申请人： Kazuyoshi Sotoyama ,  Keiji Iwatsuki ,  Teruhiko Mizota ,  Yuzo Asano ,  Masayuki Akiyama ,  Yuriko Iiyama

发明人： Kazuyoshi Sotoyama ,  Keiji Iwatsuki ,  Teruhiko Mizota ,  Yuzo Asano ,  Masayuki Akiyama ,  Yuriko Iiyama

IPC分类号： B01F3/04

CPC分类号： B01J19/1887 ,  A23C7/04 ,  A23F5/505 ,  A23L5/23 ,  A23L27/10 ,  B01D3/30 ,  B01F3/04035 ,  B01F3/04496 ,  B01J10/02 ,  B01J19/006 ,  B01J19/0066 ,  B01J2219/00779

摘要： Vapor-liquid contacting equipment includes a contact column in which a test liquid flows from top to bottom and a vapor flows from bottom to top, a rotary shaft which is inserted vertically in the contact column, rotors which are provided at different heights on the shaft, and which convert the test liquid into a thin film by centrifugal force and then discharge the test liquid from the outer periphery thereof, and trays which receive the test liquid discharged from an upper rotor and guide the test liquid to the center of a lower rotor. The rotors have furrows, which the test liquid flows over when the filmy test liquid flows out from the center of the rotor towards the outer periphery.

摘要翻译： 气液接触设备包括接触柱，其中测试液体从顶部向底部流动并且蒸汽从底部流向顶部，垂直地插入接触柱中的旋转轴，设置在轴上的不同高度的转子 并且通过离心力将测试液体转化为薄膜，然后从其外周排出测试液体，以及托盘，其接收从上转子排出的测试液体并将测试液体引导到下转子的中心 。 转子具有凹槽，当薄膜测试液体从转子的中心向外周边流出时，测试液体流过。

公开(公告)号：US06673311B1

公开(公告)日：2004-01-06

申请号：US09529956

申请日：2000-06-26

申请人： Kazuyoshi Sotoyama ,  Keiji Iwatsuki ,  Teruhiko Mizota ,  Yuzo Asano ,  Yasutatsu Mizota ,  Hiroaki Matsui ,  Tetsushi Mori

发明人： Kazuyoshi Sotoyama ,  Keiji Iwatsuki ,  Teruhiko Mizota ,  Yuzo Asano ,  Yasutatsu Mizota ,  Hiroaki Matsui ,  Tetsushi Mori

IPC分类号： A61L200

CPC分类号： A23L3/0155 ,  A23L3/16 ,  A23L3/18 ,  A23L3/22 ,  A61L2/04

摘要： A method for continuous heat sterilization of liquid includes a continuous pre-heating step of preheating the liquid, a final heating step of heating the preheated liquid to reach a predetermined sterilizing temperature, a holding step of holding the liquid which has reached the predetermined sterilizing temperature for a predetermined period of time, and a cooling step of cooling the held liquid. The final heating step comprises the following steps (a) and (b): (a) a step of continuously pressurizing the liquid by a high pressure pump; and (b) a step of releasing the liquid continuously to a normal pressure within a time period of less than 10 seconds after the pressurizing step to thereby make the liquid reach the predetermined sterilizing temperature. An apparatus for automatically carrying out the method is provided. According to the continuous heat sterilization method and apparatus, scorch during the final heating step is dispensed with and accordingly, a long period of continuous operation is feasible. Furthermore, denaturation of liquid caused by heating is inconsiderable, investment cost and running cost become inexpensive, and a large amount of liquid can be processed.

摘要翻译： 一种液体的连续加热灭菌方法，包括对液体进行预热的连续预热工序，对预热液进行加热达到规定的灭菌温度的最终加热工序，保持达预定灭菌温度的液体的保持步骤 预定时间段，以及冷却保持液体的冷却步骤。 最终加热步骤包括以下步骤（a）和（b）：（a）通过高压泵连续加压液体的步骤; 和（b）在加压步骤后的10秒以内的时间内将液体连续地释放到常压的步骤，使液体达到规定的灭菌温度。 提供一种用于自动执行该方法的装置。 根据连续加热灭菌方法和装置，省去了最终加热步骤期间的焦烧，因此长时间的连续操作是可行的。 此外，由加热引起的液体的变性是不可忽视的，因此投资成本和运行成本便宜，并且可以处理大量的液体。

公开(公告)号：US20050166911A1

公开(公告)日：2005-08-04

申请号：US10516362

申请日：2003-05-28

申请人： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

发明人： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

IPC分类号： C13B50/00 ,  A23K1/16 ,  A23L1/30 ,  A23P1/06 ,  A61K31/7016 ,  A61P1/00 ,  C13B20/16 ,  C13K13/00 ,  C13K5/00

CPC分类号： A61K31/7016 ,  A23K20/163 ,  A23V2002/00 ,  A23V2250/614 ,  A23V2250/54246 ,  A23V2250/1582 ,  A23V2250/54252 ,  A23V2250/5488

摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.

摘要翻译： 通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份 乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

公开(公告)号：US07037377B2

公开(公告)日：2006-05-02

申请号：US10516362

申请日：2003-05-28

申请人： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

发明人： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

IPC分类号： C13F3/00 ,  C13D3/16

CPC分类号： A61K31/7016 ,  A23K20/163 ,  A23V2002/00 ,  A23V2250/614 ,  A23V2250/54246 ,  A23V2250/1582 ,  A23V2250/54252 ,  A23V2250/5488

摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.

摘要翻译： 通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份 乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

公开(公告)号：US5644050A

公开(公告)日：1997-07-01

申请号：US500858

申请日：1995-09-01

申请人： Seiichi Shimamura ,  Yoshitaka Tamura ,  Teruhiko Mizota ,  Itsuko Suzawa ,  Nobuo Seki

发明人： Seiichi Shimamura ,  Yoshitaka Tamura ,  Teruhiko Mizota ,  Itsuko Suzawa ,  Nobuo Seki

IPC分类号： A61K31/70 ,  A61K31/7016 ,  A61P1/16 ,  C07H1/00 ,  C07H3/04 ,  C13K13/00

CPC分类号： C07H3/04

摘要： The present invention provides a method for manufacturing lactulose anhydride, which comprises drying lactulose trihydrate at a temperature within a range of from 45.degree. to 75.degree. C. and a degree of vacuum within a range of from 25 to 100 Torr to remove water of crystallization.The method of the present invention permits manufacture of lactulose anhydride through a simple process, at a high yield and at a low cost, and is therefore suitable for mass production of lactulose anhydride in an industrial scale.

摘要翻译： PCT No.PCT / JP93 / 00841 Sec。 371 1995年9月1日 102（e）1995年9月1日PCT PCT日期：1993年6月22日PCT公布。 公开号WO94 / 18213 日本1994年8月18日本发明提供了一种制造乳果糖酐的方法，其包括在45-75℃的温度范围内干燥乳果糖三水合物，并且在25至100托的范围内的真空度 去除结晶水。 本发明的方法允许通过简单的方法以高产率和低成本制造乳果糖酐，因此适合于大规模生产工业规模的乳果糖酐。

公开(公告)号：US5266202A

公开(公告)日：1993-11-30

申请号：US655199

申请日：1991-02-14

申请人： Shigeo Okonogi ,  Mamoru Tomita ,  Yasuo Fukuwatari ,  Koichi Matsumoto ,  Yoshitaka Tamura ,  Teruhiko Mizota ,  Atsushi Nakajima ,  Haruo Endo ,  Norio Sato ,  Koji Inagaki

发明人： Shigeo Okonogi ,  Mamoru Tomita ,  Yasuo Fukuwatari ,  Koichi Matsumoto ,  Yoshitaka Tamura ,  Teruhiko Mizota ,  Atsushi Nakajima ,  Haruo Endo ,  Norio Sato ,  Koji Inagaki

IPC分类号： A23C9/142 ,  B01D61/02 ,  B01D61/12 ,  B21D61/12

CPC分类号： B01D61/12 ,  A23C9/1427 ,  B01D61/022

摘要： This invention relates to a reverse osmosis treatment process, particularly a stable reverse osmosis treatment process which prevents a lowering in throughput capacity by carrying out treatment while keeping the permeate flux of a reverse osmosis membrane constant through the time of use of a module. The process of this invention can keep the throughput capacity constant, can prevent adhesion and pollution onto membrane surfaces and fouling thereon, and moreover can maintain stable operation in a continuous run.

摘要翻译： 本发明涉及一种反渗透处理方法，特别是一种稳定的反渗透处理方法，其通过在使用模块时保持反渗透膜的渗透通量不变的同时进行处理，防止通过量下降。 本发明的方法可以保持生产能力恒定，可以防止膜表面的粘附和污染，并在其上污染，而且可以在连续运行中保持稳定的操作。

公开(公告)号：US4791193A

公开(公告)日：1988-12-13

申请号：US74034

申请日：1987-07-16

申请人： Shigeo Okonogi ,  Mamoru Tomita ,  Toshio Tomimura ,  Yoshitaka Tamura ,  Teruhiko Mizota

发明人： Shigeo Okonogi ,  Mamoru Tomita ,  Toshio Tomimura ,  Yoshitaka Tamura ,  Teruhiko Mizota

IPC分类号： C07K14/00 ,  A23J1/20

CPC分类号： A23J1/20 ,  Y10S530/832 ,  Y10S530/833

摘要： A process for producing bovine lactoferrin in high purity form raw milk-materials containing skim milk or whey originated form cow's milk which comprises: adsoption step wherein said raw materials are contacted, at a temperature between 0.degree.-60.degree. C., with weakly acidic cation-exchanger which includes carboxymethyl groups as ion exchanging groups and has haemoglobin adsorption property more than 3.5 g/100 ml; rinsing step wherein said exchanger is washed with water to remove substances other than those adsorbed to said exchanger; and desorption step wherein the substances adsorbed to said exchanger are desorbed therefrom with a solution of one or more of salts to thereby yield highly purified bovine lactoferrin without deterirating raw milk materials. Said desorption step can be carried out in a single stage to produce lactoferrin more than 80% purity to total proteins recovered, and in two stage to attain more than 98% purity.

公开(公告)号：US4142916A

公开(公告)日：1979-03-06

申请号：US902752

申请日：1978-05-03

申请人： Katsuhiro Ogasa ,  Mamoru Tomita ,  Teruhiko Mizota

发明人： Katsuhiro Ogasa ,  Mamoru Tomita ,  Teruhiko Mizota

IPC分类号： C07H3/04 ,  C13K13/00 ,  C13F1/14

CPC分类号： C13K13/005

摘要： Method for manufacturing a lactulose powder with a low hygroscopicity by mixing ethyl alcohol to a highly hygroscopic lactulose-containing powder followed by allowing the resulting mixture to stand or stirring it for at least 1 hour, separating the lactulose-containing material insoluble in ethyl alcohol from the mixture and removing ethyl alcohol from the material separated.

摘要翻译： 通过将乙醇与高吸湿性含乳果糖的粉末混合，然后使所得混合物静置或搅拌至少1小时，将不溶于乙醇的含有乳果糖的材料分离出来，制造具有低吸湿性的乳果糖粉末的方法 混合物并从分离的物质中除去乙醇。