公开(公告)号：US4921855A

公开(公告)日：1990-05-01

申请号：US204549

申请日：1988-06-09

申请人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

发明人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

IPC分类号： A61K31/415 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P43/00 ,  C07C219/18 ,  C07C233/02 ,  C07C271/08 ,  C07C281/02 ,  C07C311/53 ,  C07C313/32 ,  C07D207/16 ,  C07D211/68 ,  C07D213/36 ,  C07D231/14 ,  C07D233/54 ,  C07D233/64 ,  C07D241/08 ,  C07D277/20 ,  C07D277/34 ,  C07D277/44 ,  C07D295/14 ,  C07D295/205 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04

CPC分类号： C07D233/64 ,  C07D295/205 ,  Y02P20/55 ,  Y10S530/86

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula: ##STR2## in which R.sup.5 is hydrogen or acyl and R.sup.6 is hydrogen or lower alkyl; aryl; or amino optionally substituted with substituent(s) selected from the group consisting of lower alkyl and acyl; andR.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with substituent(s) selected from the group consisting of lower alkyl, hydroxy(lower )alkyl, lower alkoxy(lower)alkyl, acyl(lower)alkyl, oxo and acyl;R.sup.3 is hydrogen or lower alkyl; andR.sup.4 is lower alkyl;and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same.

公开(公告)号：US5223489A

公开(公告)日：1993-06-29

申请号：US828193

申请日：1992-01-30

申请人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

发明人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

IPC分类号： C07D233/54 ,  C07D295/205

CPC分类号： C07D233/64 ,  C07D295/205

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted aryl; or amino optionally substituted; andR.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted;R.sup.3 is hydrogen or lower alkyl; andR.sup.4 is lower alkyl;and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same

摘要翻译： 下式的化合物：其中R 1是低级烷基任意取代的芳基; 或氨基任选取代; R2为氢或低级烷基; 或者R1和R2与连接的氮原子一起形成任选取代的杂环基; R3是氢或低级烷基; R4为低级烷基; 及其药学上可接受的盐，其制备方法和包含其的药物组合物

公开(公告)号：US5142048A

公开(公告)日：1992-08-25

申请号：US462117

申请日：1990-01-08

申请人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

发明人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

IPC分类号： A61K31/415 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P43/00 ,  C07C219/18 ,  C07C233/02 ,  C07C271/08 ,  C07C281/02 ,  C07C311/53 ,  C07C313/32 ,  C07D207/16 ,  C07D211/68 ,  C07D213/36 ,  C07D231/14 ,  C07D233/54 ,  C07D233/64 ,  C07D241/08 ,  C07D277/20 ,  C07D277/34 ,  C07D277/44 ,  C07D295/14 ,  C07D295/205 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04

CPC分类号： C07D233/64 ,  C07D295/205 ,  Y02P20/55 ,  Y10S530/86

摘要： The invention relates to novel intermediate compounds for preparation of novel amino acid derivatives having renin inhibiting activity.

摘要翻译： 本发明涉及用于制备具有肾素抑制活性的新型氨基酸衍生物的新型中间体化合物。

公开(公告)号：US5491132A

公开(公告)日：1996-02-13

申请号：US202551

申请日：1994-02-28

申请人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Shinya Watanabe ,  Masashi Hashimoto

发明人： Keiji Hemmi ,  Masahiro Neya ,  Hiroshi Marusawa ,  Shinya Watanabe ,  Masashi Hashimoto

IPC分类号： C07D217/02 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/06 ,  C07C237/22 ,  C07D233/54 ,  C07D233/64 ,  C07D401/12 ,  C07D403/12 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07K5/06078 ,  A61K38/00 ,  Y02P20/55 ,  Y10S530/80

摘要： This invention relates to new amino acid derivatives and pharmaceutically acceptable salts thereof, wherein the amino acid derivatives are useful in the treatment and/or prevention of hypertension, heart failure, renal diseases or glaucoma.

摘要翻译： 本发明涉及新的氨基酸衍生物及其药学上可接受的盐，其中氨基酸衍生物可用于治疗和/或预防高血压，心力衰竭，肾脏疾病或青光眼。

公开(公告)号：US4929639A

公开(公告)日：1990-05-29

申请号：US208665

申请日：1988-06-20

申请人： Hiroyuki Setoi ,  Akio Kuroda ,  Hirokazu Tanaka ,  Hideo Hirai ,  Hiroshi Marusawa ,  Masashi Hashimoto

发明人： Hiroyuki Setoi ,  Akio Kuroda ,  Hirokazu Tanaka ,  Hideo Hirai ,  Hiroshi Marusawa ,  Masashi Hashimoto

IPC分类号： A61K31/357 ,  A61P7/02 ,  C07D309/06 ,  C07D319/06 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07D405/12 ,  C07D309/06 ,  C07D319/06 ,  C07D409/12

摘要： The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl andR.sup.3 is --CH.dbd.N--R.sup.4 in which R.sup.4 is arylureido or arylthioureido andX is --O--,or a pharmaceutically acceptable salt thereof.

公开(公告)号：US4916152A

公开(公告)日：1990-04-10

申请号：US187240

申请日：1988-04-28

申请人： Hiroyuki Setoi ,  Hideo Hirai ,  Hiroshi Marusawa ,  Akio Kuroda ,  Hirokazu Tanaka ,  Masashi Hashimoto

发明人： Hiroyuki Setoi ,  Hideo Hirai ,  Hiroshi Marusawa ,  Akio Kuroda ,  Hirokazu Tanaka ,  Masashi Hashimoto

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/66 ,  A61P7/00 ,  A61P7/02 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D409/12 ,  C07F9/572

CPC分类号： C07D207/16 ,  C07D207/12 ,  C07D207/14

摘要： The invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkoxycarbonyl, phenylsulfonyl, phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, nitro, lower alkoxy, mono (or di or tri)halo(lower)alkyl and lower alkyl, phenylcarbamoyl, lower alkylsulfonyl, benzoyl or thienylsulfonyl;R.sup.2 is phenylsulfonyl or phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl,R.sup.3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and 1 to 3 halogen atom(s), esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylsulfonylcarbamoyl(lower)alkyl, phenylsulfonylcarbamoyl(lower)alkyl, carboxyphenyl, esterified carboxyphenyl, carboxy, esterified carboxy, hydroxy(lower)alkyl, sulfino(lower)alkyl, phosphono(lower)alkyl, di(lower)alkoxyphosphoryl(lower)alkyl or halo(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is ##STR2## in which R.sup.8 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, useful as therapeutic agents for thrombosis, asthma and nephritis.

公开(公告)号：US06624713B2

公开(公告)日：2003-09-23

申请号：US09931495

申请日：2001-08-16

申请人： Tatsuya Matsunaga ,  Hiroshi Marusawa

发明人： Tatsuya Matsunaga ,  Hiroshi Marusawa

IPC分类号： H01P1383

CPC分类号： H01F1/346 ,  C04B35/2675

摘要： As a magnetic material for high frequencies provided in a high-frequency circuit component used as a high-frequency nonreciprocal circuit device, for example, a circulator and an isolator, a magnetic material which can be densely sintered at a relatively low temperature and has a reduced ferromagnetic resonance half width is provided. The magnetic material for high frequencies is primarily composed of yttrium iron-based garnet in which Ca substitutes for a part of Y site, and V substitutes for a part of Fe site, and does not substantially contain tetravalent nor pentavalent elements, other than V, or contains about 0.5% by weight or less of oxide of this element, and the ratio of Ca atoms to V atoms, Ca/V, falls within the range of 2.0

公开(公告)号：US5356897A

公开(公告)日：1994-10-18

申请号：US931093

申请日：1992-08-17

申请人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Marusawa ,  Hitoshi Yamazaki ,  Yoshito Abe ,  Hirokazu Tanaka

发明人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Marusawa ,  Hitoshi Yamazaki ,  Yoshito Abe ,  Hirokazu Tanaka

IPC分类号： A61K31/415 ,  A61K31/505 ,  A61K31/53 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： This invention relates to heterocyclic derivatives useful for inhibiting the production of Interleukin-1 (IL-1) and tumor necrosis factor (TNF) and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.

摘要翻译： 本发明涉及可用于抑制白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）等的产生的杂环衍生物，其可以由下式表示：（I） 它们的生产，涉及含有该组合物的药物组合物及其用途。

公开(公告)号：US06803130B1

公开(公告)日：2004-10-12

申请号：US09697542

申请日：2000-10-26

申请人： Kunisaburo Tomono ,  Takashi Toda ,  Takashi Ohsawa ,  Mitsuhiro Fukushima ,  Hiroshi Marusawa

发明人： Kunisaburo Tomono ,  Takashi Toda ,  Takashi Ohsawa ,  Mitsuhiro Fukushima ,  Hiroshi Marusawa

IPC分类号： B32B900

CPC分类号： H01F1/37 ,  H01F1/344 ,  H01F17/04 ,  Y10T428/115 ,  Y10T428/32

摘要： A composite magnetic material comprises a ferrite powder and a resin in which the powder comprises a spinel type ferrite including at least Ni and Co.

摘要翻译： 复合磁性材料包括铁氧体粉末和其中粉末包括至少包括Ni和Co的尖晶石型铁氧体的树脂

公开(公告)号：US5976679A

公开(公告)日：1999-11-02

申请号：US794468

申请日：1997-02-04

申请人： Kunisaburo Tomono ,  Hiroshi Marusawa

发明人： Kunisaburo Tomono ,  Hiroshi Marusawa

IPC分类号： H01F17/00 ,  H01P1/36 ,  H01P1/383 ,  H01P1/387 ,  H01P11/00 ,  B32B15/16 ,  H01P1/38

CPC分类号： H01P11/00 ,  H01P1/387 ,  Y10S428/90 ,  Y10T428/24917

摘要： A high-frequency circuit element which can be formed by firing simultaneously a microwave magnetic body and a hard magnetic body plate in the form of a laminate. The microwave magnetic body is made of calcium-vadium-iron and the hard magnetic body plate is made of strontium-iron, so that they have approximately the same firing temperature. They are separated by a screening film of palladium or platinum, which prevents the diffusion of strontium ions from the hard magnetic body plate to the microwave magnetic body. This constitution permits the simultaneous firing of the two components. The high-frequency circuit element is useful as a small, high-precision circulator, isolator, or inductor.

摘要翻译： 一种高频电路元件，其可以通过同时焙烧微波磁体和层叠体形式的硬磁体板形成。 微波磁体由钙 - 铁制成，硬磁体板由锶铁制成，因此具有大致相同的烧成温度。 它们由钯或铂的筛选膜分离，这防止锶离子从硬磁体板扩散到微波磁体。 这种结构允许同时烧制两个部件。 高频电路元件可用作小型高精度循环器，隔离器或电感器。