利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.04 秒)

    Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents
    4.
    发明授权
    Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents 失效
    喹诺酮类化合物和包含其的药物组合物，可用作抗溃疡和抗过敏剂

    公开(公告)号：US4650804A

    公开(公告)日：1987-03-17

    申请号：US712435

    申请日：1985-03-18

    申请人： Yoshihiko Kitaura ,  Teruo Oku ,  Hideo Hirai ,  Tosiyuki Yamamoto ,  Masashi Hashimoto

    发明人： Yoshihiko Kitaura ,  Teruo Oku ,  Hideo Hirai ,  Tosiyuki Yamamoto ,  Masashi Hashimoto

    IPC分类号： A61K31/435 ,  A61K31/47 ,  A61P1/04 ,  A61P37/08 ,  A61P43/00 ,  C07D455/00 ,  C07D455/02 ,  C07D455/03 ,  C07D455/04 ,  C07D455/06 ,  C07F7/18 ,  C07D221/06 ,  C07D239/02

    CPC分类号： C07D455/00 ,  C07D455/02 ,  C07D455/04 ,  C07D455/06 ,  C07F7/1856 ,  Y02P20/55

    摘要： The invention relates to novel quinolizinone compounds having inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is tetrazolylcarbamoyl;R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy;R.sup.3 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkenyloxy, phenyl, napthyl, biphenylyl, phenyl having one or more substituent(s) selected from halogen, lower alkyl and lower alkoxy, arylthio selected from phenylthio, tolylthio, xylylthio, cumenylthio, naphthylthio and biphenylthio, aroyl selected from benzoyl, toluoyl and naphthoyl, ar(lower)alkyl selected from phenyl(lower)alkyl, tolyl(lower)alkyl, xylyl(lower)alkyl, cumenyl(lower)alkyl, naphthyl(lower)alkyl and biphenylyl(lower)alkyl, arenesulfonyl selected from benzenesulfonyl and p-toluenesulfonyl, arylamino selected from phenylamino, naphthylamino, biphenylylamino, phenylamino having lower alkyl on the nitrogen atom or aryloxy selected from phenoxy and tolyloxy;or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及具有下式的过敏和溃疡抑制活性的新型喹嗪酮化合物：其中R1是四唑基氨基甲酰基; R7是氢或选自苯基，甲苯基，二甲苯基，枯烯基，萘基和联苯基的芳基; R2是氢，羟基，低级烷基或低级烷氧基; R3是氢，羟基，低级烷基，低级烷氧基，低级烯氧基，苯基，萘基，联苯基，具有一个或多个选自卤素，低级烷基和低级烷氧基的取代基的苯基，选自苯硫基，甲苯硫基，二甲苯硫基， ，萘基硫基和联苯硫基，选自苯甲酰基，甲苯酰基和萘甲酰基的芳酰基，选自苯基（低级）烷基，甲苯基（低级）烷基，二甲苯基（低级）烷基，枯烯基（低级）烷基，萘基 和选自苯磺酰基和对甲苯磺酰基的联苯基（低级）烷基，芳基磺酰基，选自苯基氨基，萘基氨基，联苯基氨基，在氮原子上具有低级烷基的苯基氨基或选自苯氧基和甲酰基氧基的芳氧基; 或其药学上可接受的盐。

    Isochroman compounds and their production process
    5.
    发明授权
    Isochroman compounds and their production process 失效
    异色素化合物及其制备方法

    公开(公告)号：US06177458B1

    公开(公告)日：2001-01-23

    申请号：US09468770

    申请日：1999-12-21

    申请人： Hideo Hirai ,  Toshio Ichiba ,  Hiroko Tonai

    发明人： Hideo Hirai ,  Toshio Ichiba ,  Hiroko Tonai

    IPC分类号： A61K3135

    CPC分类号： C12R1/80 ,  C07D311/76 ,  C12P17/06

    摘要： This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.

    摘要翻译： 本发明涉及式（I）的异苯并二氢吡喃化合物及其药学上可接受的盐，其可用作淀粉样聚集抑制剂并用于治疗阿尔茨海默氏病。 本发明还涉及异苯并二氢吡喃化合物的制备方法，该方法包括培养简单微生物FERM BP-6357的青霉菌，然后从发酵液中分离异色素化合物。 本发明还涉及包含异色满化合物的药物组合物。

    NUCLEAR REACTOR BUILDING AND CONSTRUCTION METHOD THEREOF
    7.
    发明申请
    NUCLEAR REACTOR BUILDING AND CONSTRUCTION METHOD THEREOF 有权
    核反应堆建筑及其施工方法

    公开(公告)号：US20100177859A1

    公开(公告)日：2010-07-15

    申请号：US12652976

    申请日：2010-01-06

    申请人： Shigeki Yokoyama ,  Makoto Ukai ,  Munetaka Takahashi ,  Hideo Hirai ,  Takuya Miyagawa ,  Masashi Tanabe

    发明人： Shigeki Yokoyama ,  Makoto Ukai ,  Munetaka Takahashi ,  Hideo Hirai ,  Takuya Miyagawa ,  Masashi Tanabe

    IPC分类号： G21C13/00 ,  E04B1/00

    CPC分类号： G21C13/02 ,  Y02E30/40

    摘要： In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.

    摘要翻译： 在钢板混凝土结构的核反应堆建筑物中，其容纳形成有贯穿其外围的压力容器的多个穿透口的压力容器，并且包括设置在压力容器外部的生物屏蔽壁。 压力容器垂直地分成多个块，使得每个块具有设置在同一水平面上的一个或多个压力容器渗透口，并且包括生物屏蔽壁的反应堆建筑物被分成多个模块 由水平面。

    Belt tensioner
    8.
    发明授权
    Belt tensioner 失效
    皮带张力器

    公开(公告)号：US5083983A

    公开(公告)日：1992-01-28

    申请号：US601313

    申请日：1990-10-19

    申请人： Hideo Hirai ,  Yasuhiro Hashimoto ,  Norikazu Tanaka

    发明人： Hideo Hirai ,  Yasuhiro Hashimoto ,  Norikazu Tanaka

    IPC分类号： F16H7/08 ,  F16H7/12

    CPC分类号： F16H7/1218 ,  F02B2275/06 ,  F16H2007/081

    摘要： An apparatus for tensioning a drive belt and having a tensioner arm with structure thereon for engaging a surface of the drive belt, structure for mounting the tensioner arm to a support for pivoting movement about a first axis in first and second opposite directions relative to the support including a roller bearing for guiding relative movement between the tensioner arm and support, and structure for normally biasing the belt in one of the first and second opposite directions relative to the support.

    Speed-shifting pulley with clutch mechanism
    10.
    发明授权
    Speed-shifting pulley with clutch mechanism 失效
    带离合器机构的换档滑轮

    公开(公告)号：US4568315A

    公开(公告)日：1986-02-04

    申请号：US575027

    申请日：1984-01-30

    申请人： Takashi Tomiyori ,  Hideo Hirai

    发明人： Takashi Tomiyori ,  Hideo Hirai

    IPC分类号： F16H9/12 ,  F16H7/08 ,  F16H55/56 ,  F16H11/06

    CPC分类号： F16H55/56 ,  F16H7/0827

    摘要： A variable speed pulley mounted to a torque transmission shaft having an idler structure arranged to maintain the power transmission belt centered between the pulley sheaves when the sheaves are spaced apart sufficiently to permit the belt to ride on the idler as in a stopped or idling condition of the pulley system. A tension roller may be utilized in the system for urging the belt against the outer surface of the idler, which, in the illustrated embodiment, is crowned. Structure is provided for affording facilitated adjustable movement of the adjustable sheave on the shaft, and in one embodiment, provision is made for providing lubrication therebetween.

    摘要翻译： 一种安装在转矩传动轴上的变速传动轴，其具有惰轮结构，其布置成当滑轮间隔开时将动力传递带保持在滑轮滑轮之间的中心位置，以允许皮带骑行在惰轮上，如在停止或空转状态 滑轮系统。 可以在系统中使用张紧辊来将带子推压到惰轮的外表面，在所示的实施例中，凸轮被加冠。 提供了用于提供可调节滑轮在轴上的便利的可调节运动的结构，并且在一个实施例中，提供用于在它们之间提供润滑。