利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

100 条记录 (耗时 0.03 秒)

    Process for producing cinnamaldehyde derivatives, use thereof and the like
    1.
    发明申请
    Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
    制备肉桂醛衍生物的方法及其用途等

    公开(公告)号：US20050245759A1

    公开(公告)日：2005-11-03

    申请号：US11154658

    申请日：2005-06-17

    申请人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    发明人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    IPC分类号： A23L27/30 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/072 ,  C07K5/075 ,  C07K5/04 ,  C07C45/90

    CPC分类号： C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/06113 ,  C07C47/27

    摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propyl]-L-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

    摘要翻译： 方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应 的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。 由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。 此外，通过如此制备的化合物与天冬甜素的还原烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-天冬氨酰基] - 作为具有高甜味效力的甜味剂可用的L-苯丙氨酸1-甲酯可以在工业上有效地生产。 还提供了其工艺。

    Process for producing cinnamaldehyde derivatives, use thereof and the like
    2.
    发明授权
    Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
    制备肉桂醛衍生物的方法及其用途等

    公开(公告)号：US07141263B2

    公开(公告)日：2006-11-28

    申请号：US11154658

    申请日：2005-06-17

    申请人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    发明人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    IPC分类号： A23L1/236 ,  C07C229/00

    CPC分类号： C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/06113 ,  C07C47/27

    摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propyl]-L-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

    摘要翻译： 方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应 的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。 由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。 此外，通过如此制备的化合物与天冬甜素的还原烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-天冬氨酰基] - 作为具有高甜味效力的甜味剂可用的L-苯丙氨酸1-甲酯可以在工业上有效地生产。 还提供了其工艺。

    Process for producing cinnamaldehyde derivatives, use thereof and the like
    3.
    发明授权
    Process for producing cinnamaldehyde derivatives, use thereof and the like 有权
    制备肉桂醛衍生物的方法及其用途等

    公开(公告)号：US06965055B2

    公开(公告)日：2005-11-15

    申请号：US10295997

    申请日：2002-11-18

    申请人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    发明人： Kenichi Mori ,  Shinji Fujita ,  Nao Funakoshi ,  Tadashi Takemoto

    IPC分类号： A23L27/30 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/072 ,  C07K5/075 ,  C07C45/72

    CPC分类号： C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C47/277 ,  C07K5/06113 ,  C07C47/27

    摘要： A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

    摘要翻译： 方便有效地制备高纯度肉桂醛衍生物的方法，例如（2E） - （3-羟基-4-甲氧基）肉桂醛，其包括使苯甲醛衍生物如异喹啉腈等与乙醛在存在下反应 的碱，特别优选在低温下在水溶液中逐滴滴加乙醛进行反应。 由此得到的肉桂醛衍生物被选择性地还原以产生3-（3-羟基-4-取代的（与甲氧基等）苯基）丙醛。 此外，通过如此制备的化合物与天冬甜素的还原性烷基化反应，N- [N- [3-（3-羟基-4-取代的（与甲氧基等）苯基）丙基] -L-α-天冬氨酰基 ] -L-苯丙氨酸1-甲酯，其可用作具有高甜味效力的甜味剂，可以在工业上有效地制备。 还提供了其工艺。