摘要:
The present invention provides, as a resin bead which can be developed for use completely different from the use of conventional polystyrene resin beads, a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contain a hydroxyl group in an amount of 10–1000 μmol/g, and further, a production method of a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contains suspension copolymerization of a styrene monomer, an acyloxystyrene monomer and a divinylbenzene monomer using an organic solvent (containing at least hydrocarbon and alcohol) and water, followed by hydrolysis reaction.
摘要:
The present invention provides, as a resin bead which can be developed for use completely different from the use of conventional polystyrene resin beads, a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contain a hydroxyl group in an amount of 10-1000 μmol/g, and further, a production method of a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contains suspension copolymerization of a styrene monomer, an acyloxystyrene monomer and a divinylbenzene monomer using an organic solvent (containing at least hydrocarbon and alcohol) and water, followed by hydrolysis reaction.
摘要:
The present invention relates to a support for solid-phase synthesis, which contains a porous copolymer particle, the copolymer particle containing 25 to 60% by weight of an aromatic-vinyl structural unit, 20 to 55% by weight of a vinyl cyamide structural unit, 5 to 18% by weight of an ethylenically-unsaturated-carboxylic-acid structural unit, and 2 to 15% by weight of an aromatic-divinyl structural unit. The support according to the invention fluctuates little in the degree of swelling depending on the kind of the organic solvent in contact therewith.
摘要:
The present invention relates to a method for producing a porous resin particle having a functional group X, the method including: dissolving a radical polymerizable aromatic monovinyl monomer and a radical polymerizable aromatic divinyl monomer together with a polymerization initiator in an organic solvent to prepare a monomer solution, dispersing the monomer solution in water in the presence of a dispersion stabilizer to obtain a suspension polymerization reaction mixture, and performing a suspension copolymerization while adding, when 0 to 80% of the entire polymerization time of the suspension copolymerization is passed, a mercapto compound represented by the formula (I): HS—R—X (I) in which R represents an alkylene group having a carbon number of 2 to 12, and the functional group X represents a functional group selected from a hydroxy group and a primary amino group, to the suspension polymerization reaction mixture; and the porous resin particle obtained by the method.
摘要:
The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction lots. A nucleic acid synthesis reaction is carried out on a first solid phase carrier capable of supporting nucleic acid synthesis contained in a solid phase carrier mixture comprising the first solid phase carrier and a second solid phase carrier that does not support nucleic acid synthesis.
摘要:
The present invention relates to a support for solid-phase synthesis, which contains a porous copolymer particle, the copolymer particle containing 25 to 60% by weight of an aromatic-vinyl structural unit, 20 to 55% by weight of a vinyl cyamide structural unit, 5 to 18% by weight of an ethylenically-unsaturated-carboxylic-acid structural unit, and 2 to 15% by weight of an aromatic-divinyl structural unit. The support according to the invention fluctuates little in the degree of swelling depending on the kind of the organic solvent in contact therewith.
摘要:
The present invention provides porous resin beads containing an aromatic monovinyl compound-divinyl compound-(meth)acrylamide derivative copolymer. Preferably, the copolymer further contains as a structural unit a second aromatic monovinyl compound having a functional group capable of binding to a carboxyl group by a dehydrating condensation reaction.
摘要:
The present invention provides a method of producing porous spherical particles, which includes suspension polymerization of a multifunctional monomer having two or more vinyl groups and a vinyl monomer having one vinyl group in an aqueous medium in the presence of a porogen and a distribution stabilizer, wherein the distribution stabilizer is polyvinyl alcohol having a saponification degree of 75 to 85 mol %. According to the method of the present invention, generation of particle agglomerates and large particles can be suppressed and porous spherical particles having a desired average particle size and a narrow particle size distribution can be conveniently produced.
摘要:
The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae wherein each symbol is as defined in the specification.
摘要:
The present invention provides porous resin beads containing an aromatic monovinyl compound-divinyl compound-(meth)acrylamide derivative copolymer. Preferably, the copolymer further contains as a structural unit a second aromatic monovinyl compound having a functional group capable of binding to a carboxyl group by a dehydrating condensation reaction.