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    PRODUCTION METHOD OF POROUS SPHERICAL PARTICLES OF VINYL POLYMER
    1.
    发明申请
    PRODUCTION METHOD OF POROUS SPHERICAL PARTICLES OF VINYL POLYMER 有权
    乙烯聚合物多孔球形体的制备方法

    公开(公告)号：US20050272890A1

    公开(公告)日：2005-12-08

    申请号：US11143384

    申请日：2005-06-02

    申请人： Tatsuya Konishi ,  Takeo Matsumura ,  Kenjiro Mori

    发明人： Tatsuya Konishi ,  Takeo Matsumura ,  Kenjiro Mori

    IPC分类号： C08F2/20 ,  C08F12/00 ,  C08F112/08 ,  C08F112/36 ,  C08F212/08 ,  C08F212/36 ,  C08F20/44

    CPC分类号： C08F2/20 ,  C08F112/08 ,  C08F112/36 ,  Y10S526/909 ,  C08F2/44

    摘要： The present invention provides a method of producing porous spherical particles, which includes suspension polymerization of a multifunctional monomer having two or more vinyl groups and a vinyl monomer having one vinyl group in an aqueous medium in the presence of a porogen and a distribution stabilizer, wherein the distribution stabilizer is polyvinyl alcohol having a saponification degree of 75 to 85 mol %. According to the method of the present invention, generation of particle agglomerates and large particles can be suppressed and porous spherical particles having a desired average particle size and a narrow particle size distribution can be conveniently produced.

    摘要翻译： 本发明提供一种制造多孔球形颗粒的方法，其包括在致孔剂和分布稳定剂的存在下，在含水介质中具有两个或多个乙烯基的多官能单体和具有一个乙烯基的乙烯基单体的悬浮聚合，其中 分散稳定剂是皂化度为75〜85摩尔％的聚乙烯醇。 根据本发明的方法，可以抑制颗粒附聚物和大颗粒的产生，并且可以方便地制备具有期望的平均粒度和窄的粒度分布的多孔球形颗粒。

    Production method of porous spherical particles of vinyl polymer
    2.
    发明授权
    Production method of porous spherical particles of vinyl polymer 有权
    乙烯基聚合物多孔球形颗粒的生产方法

    公开(公告)号：US07122582B2

    公开(公告)日：2006-10-17

    申请号：US11143384

    申请日：2005-06-02

    申请人： Tatsuya Konishi ,  Takeo Matsumura ,  Kenjiro Mori

    发明人： Tatsuya Konishi ,  Takeo Matsumura ,  Kenjiro Mori

    IPC分类号： C08F2/20

    CPC分类号： C08F2/20 ,  C08F112/08 ,  C08F112/36 ,  Y10S526/909 ,  C08F2/44

    摘要： The present invention provides a method of producing porous spherical particles, which includes suspension polymerization of a multifunctional monomer having two or more vinyl groups and a vinyl monomer having one vinyl group in an aqueous medium in the presence of a porogen and a distribution stabilizer, wherein the distribution stabilizer is polyvinyl alcohol having a saponification degree of 75 to 85 mol %. According to the method of the present invention, generation of particle agglomerates and large particles can be suppressed and porous spherical particles having a desired average particle size and a narrow particle size distribution can be conveniently produced.

    摘要翻译： 本发明提供一种制造多孔球形颗粒的方法，其包括在致孔剂和分布稳定剂的存在下，在含水介质中具有两个或多个乙烯基的多官能单体和具有一个乙烯基的乙烯基单体的悬浮聚合，其中 分散稳定剂是皂化度为75〜85摩尔％的聚乙烯醇。 根据本发明的方法，可以抑制颗粒附聚物和大颗粒的产生，并且可以方便地制备具有期望的平均粒度和窄的粒度分布的多孔球形颗粒。

    Porous resin particle having hydroxy group or primary amino group and production method thereof
    3.
    发明授权
    Porous resin particle having hydroxy group or primary amino group and production method thereof 有权
    具有羟基或伯氨基的多孔树脂颗粒及其制备方法

    公开(公告)号：US08076383B2

    公开(公告)日：2011-12-13

    申请号：US12265270

    申请日：2008-11-05

    申请人： Tatsuya Konishi ,  Kenjiro Mori

    发明人： Tatsuya Konishi ,  Kenjiro Mori

    IPC分类号： C08J9/28

    CPC分类号： C08F2/38 ,  C07K1/042 ,  C08K5/3725 ,  Y10T428/2987 ,  C08F212/08 ,  C08F212/36 ,  C08F214/14

    摘要： The present invention relates to a method for producing a porous resin particle having a functional group X, the method including: dissolving a radical polymerizable aromatic monovinyl monomer and a radical polymerizable aromatic divinyl monomer together with a polymerization initiator in an organic solvent to prepare a monomer solution, dispersing the monomer solution in water in the presence of a dispersion stabilizer to obtain a suspension polymerization reaction mixture, and performing a suspension copolymerization while adding, when 0 to 80% of the entire polymerization time of the suspension copolymerization is passed, a mercapto compound represented by the formula (I): HS—R—X  (I) in which R represents an alkylene group having a carbon number of 2 to 12, and the functional group X represents a functional group selected from a hydroxy group and a primary amino group, to the suspension polymerization reaction mixture; and the porous resin particle obtained by the method.

    摘要翻译： 本发明涉及一种具有官能团X的多孔树脂颗粒的制造方法，该方法包括：将可自由基聚合的芳族单乙烯基单体和可自由基聚合的芳族二乙烯基单体与聚合引发剂一起溶解在有机溶剂中以制备单体 溶液，在分散稳定剂的存在下将单体溶液分散在水中，得到悬浮聚合反应混合物，进行悬浮共聚，同时加入悬浮聚合的全部聚合时间的0〜80％时，将巯基 由式（I）表示的化合物：其中R表示碳数为2〜12的亚烷基的HS-R-X（I），官能团X表示选自羟基和伯 氨基，悬浮聚合反应混合物; 和通过该方法获得的多孔树脂颗粒。

    Method of producing a nucleic acid
    4.
    发明授权
    Method of producing a nucleic acid 有权
    生产核酸的方法

    公开(公告)号：US08093371B2

    公开(公告)日：2012-01-10

    申请号：US12488971

    申请日：2009-06-22

    申请人： Eri Maeta ,  Kenjiro Mori ,  Tatsuya Konishi

    发明人： Eri Maeta ,  Kenjiro Mori ,  Tatsuya Konishi

    IPC分类号： C07H21/00 ,  C12Q1/68 ,  C12P19/34

    CPC分类号： C07H21/00

    摘要： The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction lots. A nucleic acid synthesis reaction is carried out on a first solid phase carrier capable of supporting nucleic acid synthesis contained in a solid phase carrier mixture comprising the first solid phase carrier and a second solid phase carrier that does not support nucleic acid synthesis.

    摘要翻译： 本发明提供了以高反应效率和高再现性生产核酸的方法，其中不同反应批次中产率和纯度的变化减小。 核酸合成反应在能够支持含有第一固相载体和不支持核酸合成的第二固相载体的固相载体混合物中的核酸合成的第一固相载体上进行。

    Support for solid-phase synthesis and process for producing the same
    5.
    发明授权
    Support for solid-phase synthesis and process for producing the same 有权
    支持固相合成及其制备方法

    公开(公告)号：US07872084B2

    公开(公告)日：2011-01-18

    申请号：US11834132

    申请日：2007-08-06

    申请人： Tatsuya Konishi ,  Kenjiro Mori

    发明人： Tatsuya Konishi ,  Kenjiro Mori

    IPC分类号： C08F20/44 ,  C08F20/06 ,  B65D39/00 ,  B32B5/16

    CPC分类号： C08F220/44 ,  C08F212/10 ,  C08F212/14 ,  C08F212/36 ,  C08F220/06 ,  Y10T428/1376 ,  Y10T428/254 ,  Y10T428/2993

    摘要： The present invention relates to a support for solid-phase synthesis, which contains a porous copolymer particle, the copolymer particle containing 25 to 60% by weight of an aromatic-vinyl structural unit, 20 to 55% by weight of a vinyl cyamide structural unit, 5 to 18% by weight of an ethylenically-unsaturated-carboxylic-acid structural unit, and 2 to 15% by weight of an aromatic-divinyl structural unit. The support according to the invention fluctuates little in the degree of swelling depending on the kind of the organic solvent in contact therewith.

    摘要翻译： 本发明涉及固相合成用载体，其含有多孔共聚物粒子，该共聚物粒子含有25〜60重量％的芳香族 - 乙烯基结构单元，20〜55重量％的乙烯基芳香胺结构单元 ，5〜18重量％的烯键式不饱和羧酸结构单元和2〜15重量％的芳香族 - 二乙烯基结构单元。 根据本发明的载体根据与其接触的有机溶剂的种类，几乎不发生溶胀度。

    Porous resin bead production method
    7.
    发明授权
    Porous resin bead production method 有权
    多孔树脂珠生产方法

    公开(公告)号：US07153890B2

    公开(公告)日：2006-12-26

    申请号：US10928831

    申请日：2004-08-27

    申请人： Kenjiro Mori ,  Tatsuya Konishi ,  Ayako Matsunawa

    发明人： Kenjiro Mori ,  Tatsuya Konishi ,  Ayako Matsunawa

    IPC分类号： C08F8/12

    CPC分类号： C08J9/16 ,  C08F8/12 ,  C08F212/14 ,  C08J2325/08 ,  C08F212/08 ,  C08F212/36

    摘要： The present invention provides, as a resin bead which can be developed for use completely different from the use of conventional polystyrene resin beads, a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contain a hydroxyl group in an amount of 10–1000 μmol/g, and further, a production method of a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contains suspension copolymerization of a styrene monomer, an acyloxystyrene monomer and a divinylbenzene monomer using an organic solvent (containing at least hydrocarbon and alcohol) and water, followed by hydrolysis reaction.

    摘要翻译： 本发明提供作为可以与常规聚苯乙烯树脂珠粒完全不同的开发用树脂珠，由含有羟基的苯乙烯 - 羟基苯乙烯 - 二乙烯基苯共聚物制成的多孔树脂珠粒的量为10 -1000mumol / g，此外，由苯乙烯 - 羟基苯乙烯 - 二乙烯基苯共聚物制成的多孔树脂珠粒的制造方法，其使用有机溶剂（包含苯乙烯 - 羟基苯乙烯 - 二乙烯基苯共聚物）包含苯乙烯单体，酰氧基苯乙烯单体和二乙烯基苯单体的悬浮共聚 最少的烃和醇）和水，然后进行水解反应。

    Production method of porous resin particle having hydroxyl group
    10.
    发明授权
    Production method of porous resin particle having hydroxyl group 有权
    具有羟基的多孔树脂颗粒的制造方法

    公开(公告)号：US08487013B2

    公开(公告)日：2013-07-16

    申请号：US12265015

    申请日：2008-11-05

    申请人： Kenjiro Mori ,  Tatsuya Konishi

    发明人： Kenjiro Mori ,  Tatsuya Konishi

    IPC分类号： C08J9/28

    CPC分类号： C08F2/20 ,  C08F212/08 ,  C08F212/36 ,  C08F2220/281 ,  C08F2220/302 ,  C08F212/14

    摘要： The present invention relates to a method for producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an aromatic divinyl compound and a (meth)acrylic acid ester having one hydroxyl group within the molecule thereof, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; and performing a suspension copolymerization. The method of the invention is capable of easily producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, that is used as a support for solid phase synthesis and enables efficient nucleic acid synthesis.

    摘要翻译： 本发明涉及含有具有羟基的芳香族乙烯基化合物 - 芳香族二乙烯基化合物共聚物的多孔性树脂粒子的制造方法，该方法包括：将含有芳族乙烯基化合物，芳族二乙烯基化合物和（甲基） ）丙烯酸酯和分子内具有一个羟基的聚合引发剂，得到含有单体混合物和聚合引发剂的溶液; 在分散稳定剂的存在下将溶液悬浮在水中; 并进行悬浮共聚。 本发明的方法能够容易地制备含有具有羟基的芳族乙烯基化合物 - 芳族二乙烯基化合物共聚物的多孔树脂颗粒，其用作固相合成的载体并能够有效地进行核酸合成。