公开(公告)号：US6141205A

公开(公告)日：2000-10-31

申请号：US103876

申请日：1998-06-24

Applicant: Thomas M. Nutzman ,  Mark D. Breyen ,  William L. Johnson ,  Joseph F. Lessar ,  Anthony W. Rorvick ,  Kurt J. Casby ,  Thomas P. Miltich

Inventor： Thomas M. Nutzman ,  Mark D. Breyen ,  William L. Johnson ,  Joseph F. Lessar ,  Anthony W. Rorvick ,  Kurt J. Casby ,  Thomas P. Miltich

IPC: A61N1/375 ,  A61N1/39 ,  H01G7/00 ,  H01G9/045 ,  H01G9/10 ,  A61N1/301

CPC classification number: A61N1/375 ,  A61N1/3956

Abstract: An implantable medical device such as a defibrillator is described. The device includes an hermetically sealed housing containing a flat electrolytic capacitor and an energy source such as a battery. The battery is connected to the capacitor and provides charge thereto. The capacitor stores the charge at a relatively high voltage. The charge stored in the capacitor is discharged through a defibrillation lead to a site on or in the heart when fibrillation of the heart is detected by the implantable medical device. Methods of making and using the implantable medical device, the capacitor, and their various components are disclosed.

Abstract translation: 描述了诸如除颤器的可植入医疗装置。 该装置包括一个包含平坦的电解电容器和诸如电池的能量源的气密密封的外壳。 电池连接到电容器并提供电荷。 电容器将电荷存储在较高的电压。 存储在电容器中的电荷通过除颤导线排出到心脏上或心脏中的部位，通过可植入医疗装置检测心脏的颤动。 公开了制造和使用可植入医疗装置，电容器及其各种部件的方法。

公开(公告)号：US6090503A

公开(公告)日：2000-07-18

申请号：US61402

申请日：1998-04-16

Applicant: William J. Taylor ,  Joseph F. Lessar ,  Louis E. Halperin ,  Robert E. Kraska

Inventor： William J. Taylor ,  Joseph F. Lessar ,  Louis E. Halperin ,  Robert E. Kraska

IPC: C03C8/24 ,  C03C29/00 ,  H01M2/06 ,  H01M2/08

CPC classification number: C03C29/00 ,  C03C8/24 ,  H01M2/065 ,  H01M2/08

Abstract: A body implanted device including a container having an opening through which extends an electrical feedthrough. The feedthrough includes a terminal of bio-stable material. A glass insulator is positioned around the terminal. The glass insulator is chosen from a CABAL-12 type composition or variation thereof. The terminal is comprised of a material which has thermal expansion characteristics compatible with the glass seal. For glass seals having a thermal expansion in the range of 6.8 to 8.0.times.10.sup.-6 in/in/.degree. C. the terminal is comprised of a thin layer of titanium metallurgically clad over niobium or tantalum. For glass seals having a thermal expansion in the range of 8.0 to 9.0.times.10.sup.-6 in/in/.degree. C. the terminal is comprised of platinum, platinum-iridium or alloys of either, or of pure titanium.

Abstract translation: 一种体植入装置，包括具有开口的容器，所述开口延伸有电馈通孔。 馈通包括生物稳定材料的终端。 玻璃绝缘子位于端子周围。 玻璃绝缘体选自CABAL-12型组合物或其变体。 端子由具有与玻璃密封相容的热膨胀特性的材料构成。 对于热膨胀在6.8至8.0×10 -6 in / in /℃范围内的玻璃密封件，该端子由冶金地覆盖在铌或钽上的钛薄层构成。 对于热膨胀范围为8.0至9.0×10 -6 in / in /℃的玻璃密封件，该端子由铂，铂 - 铱或纯钛的合金组成。

公开(公告)号：US5870272A

公开(公告)日：1999-02-09

申请号：US852198

申请日：1997-05-06

Applicant: Lynn M. Seifried ,  Joseph F. Lessar ,  William D. Wolf ,  Mary A. Fraley ,  Kevin K. Tidemand ,  David B. Engmark ,  Ronald F. Hoch ,  Craig L. Wiklund

Inventor： Lynn M. Seifried ,  Joseph F. Lessar ,  William D. Wolf ,  Mary A. Fraley ,  Kevin K. Tidemand ,  David B. Engmark ,  Ronald F. Hoch ,  Craig L. Wiklund

IPC: A61N1/375 ,  H01G4/35 ,  H01G4/008

CPC classification number: A61N1/3754 ,  A61N1/3718 ,  Y10T29/435

Abstract: A capacitive filter feedthrough assembly and method of making the same are disclosed for shielding an implantable medical device such as pacemaker or defibrillator from electromagnetic interference or noise. A ferrule is adapted for mounting onto a conductive device housing by welding, soldering, brazing or gluing, and supports a terminal pin for feedthrough passage to a housing interior. A capacitive filter is mounted at the inboard side of a device housing, with capacitive filter electrode plate sets coupled respectively to the housing and the terminal pin by an electrically conductive combination of solder and brazing. In one embodiment of the invention, multiple capacitive filters are provided in an array within a common base structure, where each capacitive filter is associated with a respective terminal pin.

Abstract translation: 公开了电容式滤波器馈通组件及其制造方法，用于屏蔽诸如起搏器或除颤器之类的可植入医疗装置免受电磁干扰或噪声。 套圈适于通过焊接，焊接，钎焊或胶合来安装到导电装置壳体上，并且将用于穿通通道的端子销支撑到壳体内部。 电容滤波器安装在器件壳体的内侧，电容滤波器电极板组通过焊料和钎焊的导电组合分别耦合到壳体和端子销。 在本发明的一个实施例中，多个电容滤波器以公共基底结构的阵列提供，其中每个电容滤波器与相应的端子引脚相关联。

公开(公告)号：US5175067A

公开(公告)日：1992-12-29

申请号：US611902

申请日：1990-11-09

Applicant: William J. Taylor ,  Joseph F. Lessar

Inventor： William J. Taylor ,  Joseph F. Lessar

IPC: C03C8/24 ,  C03C29/00 ,  H01B17/30 ,  H01M2/06 ,  H01M2/08

CPC classification number: C03C8/24 ,  C03C29/00 ,  H01B17/305 ,  H01M2/065 ,  H01M2/08

Abstract: Use of molydenum-containing alloys to induce wetting by TA-23 glass in metallic feedthroughs.

Abstract translation: 使用含钼合金在金属馈通中诱导TA-23玻璃的润湿。

公开(公告)号：US07138582B2

公开(公告)日：2006-11-21

申请号：US10601472

申请日：2003-06-24

Applicant: Joseph F. Lessar ,  Kenenth E. Cobian ,  Peter B. McIntyre ,  David W. Mayer

Inventor： Joseph F. Lessar ,  Kenenth E. Cobian ,  Peter B. McIntyre ,  David W. Mayer

IPC: H01B5/00

CPC classification number: A61N1/056

Abstract: A medical electrical lead having an elongated conductor including one or more wires made of a modified MP35N alloy. The modified MP35N alloy is formed from a melt composition modified to reduce an amount of titanium-based inclusion forming elements.

Abstract translation: 一种具有细长导体的医用电线，包括由改良的MP35N合金制成的一根或多根线。 改性MP35N合金由改性的熔体组合物形成，以减少钛基夹杂物形成元素的量。

公开(公告)号：US06622046B2

公开(公告)日：2003-09-16

申请号：US09850331

申请日：2001-05-07

Applicant: Mary A. Fraley ,  Ronald F. Hoch ,  George Johnstone ,  Joseph F. Lessar ,  Lynn M. Seifried ,  James Strom

Inventor： Mary A. Fraley ,  Ronald F. Hoch ,  George Johnstone ,  Joseph F. Lessar ,  Lynn M. Seifried ,  James Strom

IPC: A61N105

CPC classification number: A61N1/378 ,  A61N1/3754 ,  A61N1/3756 ,  H01M2/1066 ,  H01M2/20

Abstract: Structures and methods relating to electrodes for incorporation into a feedthrough with a profile adapted for subcutaneous sensing of physiologic and cardiac signals. Electrode assemblies are adapted for integration with feedthrough to enable maximal electrode spacing, minimal myopotential electrical noise and provide reliable insulation from the IMD housing. Various structures and manufacturing processes are implemented to provide a large sensing surface with a low profile. The subcutaneous sensing electrode assembly provides a leadless sensing system and further enhances installation and follow-up procedures.

公开(公告)号：US6076017A

公开(公告)日：2000-06-13

申请号：US22321

申请日：1998-02-11

Applicant: William J. Taylor ,  John D. Wright ,  Joseph F. Lessar ,  Gary F. LaBree

Inventor： William J. Taylor ,  John D. Wright ,  Joseph F. Lessar ,  Gary F. LaBree

IPC: A61N1/375 ,  H01M2/06 ,  H01M2/10 ,  H01M2/30 ,  H01M6/16

CPC classification number: H01M2/065 ,  A61N1/3752 ,  H01M6/16 ,  H01M2/1022 ,  H01M2/1066 ,  H01M2/30

Abstract: A centerless grinding method of finishing feedthrough pins and corresponding devices for use in implantable medical devices and for components such as batteries in implantable medical devices is disclosed. The method provides certain advantages, including the elimination of longitudinal anomalies in drawn wire to thereby improve the hermeticity of implantable medical devices. In one of the preferred methods, the surface of an over-size medical grade wire having a known anomaly depth is centerless ground using an abrasive wheel and suitable coolant to a layer past which those anomalies disappear.

Abstract translation: 公开了一种用于可植入医疗装置和诸如可植入医疗装置中的电池的部件的整流穿通销和相应装置的无心磨削方法。 该方法提供了一些优点，包括消除拉丝中的纵向异常，从而提高可植入医疗装置的气密性。 在优选的方法之一中，具有已知异常深度的超大尺寸医用级线材的表面是使用砂轮和适当的冷却剂进行无心磨削，通过这些异常消失的层。

公开(公告)号：US5411545A

公开(公告)日：1995-05-02

申请号：US212476

申请日：1994-03-14

Applicant: Mark D. Breyen ,  Naim S. Istephanous ,  Robert E. Kraska ,  Joseph F. Lessar ,  Jennifer P. Miller

Inventor： Mark D. Breyen ,  Naim S. Istephanous ,  Robert E. Kraska ,  Joseph F. Lessar ,  Jennifer P. Miller

IPC: A61N1/05

CPC classification number: A61N1/056

Abstract: A medical electrical lead of the type which includes an electrode at a distal end of the lead a connector at a proximal end of the lead and an elongated electrical conductor extending between the electrode and the connector. The conductor is comprised of a wire wound in a coil configuration with the wire comprised of a duplex stainless steel having a composition of at least 22% chromium, 3% molybdenum and 5% nickel. Material of such composition has been found to have suitable conductivity for use with implantable pulse generators and suitable fatigue strength when used in endocardial lead placement. Moreover, such material has been found to pass tests intended to detect metal ion oxidation (MIO) in polymeric materials.

Abstract translation: 一种医用电引线，其包括在引线的远端处的电极，在引线的近端处的连接器和在电极和连接器之间延伸的细长电导体。 该导体由卷绕成线圈构造的线组成，线由具有至少22％铬，3％钼和5％镍组成的双相不锈钢组成。 已经发现，这种组合物的材料具有适合的导电性，用于可植入的脉冲发生器，并且当用于心内膜引导放置时具有合适的疲劳强度。 此外，已经发现这种材料通过用于检测聚合物材料中的金属离子氧化（MIO）的测试。

公开(公告)号：US5294241A

公开(公告)日：1994-03-15

申请号：US019946

申请日：1993-02-19

Applicant: William J. Taylor ,  Joseph F. Lessar ,  Weiss J. Douglas ,  Charles N. Wilson

Inventor： William J. Taylor ,  Joseph F. Lessar ,  Weiss J. Douglas ,  Charles N. Wilson

IPC: C03C27/04

CPC classification number: C03C27/044 ,  Y10S228/903

Abstract: A method for making a seal between a sealing glass and titanium by forming a nitride layer on the titanium and then sealing the glass to the nitrided titanium. The formation of the nitride layer can be accomplished by the steps of placing the titanium in a substantially oxygen-free atmosphere comprising a major amount of an inert gas and a minor amount of nitrogen and heating the titanium in that atmosphere to a temperature of at least 300.degree. C. The method allows for the formation of the nitride layer and the glass seal in a single operation. The method works well in the manufacture of feedthroughs with conventional processing equipment.

Abstract translation: 一种通过在钛上形成氮化物层然后将玻璃密封到氮化钛上而在密封玻璃和钛之间进行密封的方法。 可以通过以下步骤来实现氮化物层的形成：将钛置于包含大量惰性气体和少量氮气的基本上无氧的气氛中，并将该气氛中的钛加热到至少 该方法允许在单次操作中形成氮化物层和玻璃密封件。 该方法在具有常规加工设备的馈通制造中工作良好。

公开(公告)号：US4860446A

公开(公告)日：1989-08-29

申请号：US156145

申请日：1988-02-16

Applicant: Joseph F. Lessar ,  Duane L. Rosenberg ,  Robert E. Kraska ,  James M. Speckien ,  James E. Upton

Inventor： Joseph F. Lessar ,  Duane L. Rosenberg ,  Robert E. Kraska ,  James M. Speckien ,  James E. Upton

IPC: A61N1/05 ,  C23C14/20 ,  H01B7/00 ,  H01B7/04

CPC classification number: C23C14/20 ,  A61N1/056 ,  H01B7/0009 ,  Y10T29/49176

Abstract: A medical electrical lead having a polyurethane outer sheath and one or more coiled metal conductors. The metal conductors are optimized for use in conjunction with a polyurethane sheath and are provided with a barrier coating of a biocompatible metal. The conductors may additionally be provided with an outer, insulative coating.