公开(公告)号：US07632303B1

公开(公告)日：2009-12-15

申请号：US10152150

申请日：2002-05-21

申请人： Kent C. B. Stalker ,  Masoud Molaei ,  John F. Boylan ,  Matthew J. Gillick

发明人： Kent C. B. Stalker ,  Masoud Molaei ,  John F. Boylan ,  Matthew J. Gillick

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61F2/95 ,  A61F2002/9665 ,  A61F2250/0018

摘要： A medical device has a structure differentiated in terms of its stiffness or elasticity. Such stiffness differentiation is achieved through the use of superelastic or shape-memory materials which transition between a relatively malleable phase to a stiffer phase at a transition temperature which is adjustable by heat treatment. A differentiation of the stiffness of the structure forming the medical device is achieved by differentially adjusting the transition temperature of select portions of the medical device before the medical device is placed in its operational mode, usually implanted in a body at body temperature.

摘要翻译： 医疗器械具有在其刚性或弹性方面不同的结构。 这种刚度分化是通过使用超弹性或形状记忆材料来实现的，该材料在可通过热处理可调节的转变温度下在相对可延展的相到较硬相之间转变。 形成医疗装置的结构的刚度的差异通过在将医疗装置置于其操作模式之前差异调节医疗装置的选择部分的转变温度来实现，通常在体温下植入体内。

公开(公告)号：US20110039013A1

公开(公告)日：2011-02-17

申请号：US12540302

申请日：2009-08-12

申请人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

发明人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

IPC分类号： B05D3/04 ,  B05C5/00 ,  B05C13/02 ,  B05C11/00

CPC分类号： F26B9/06 ,  A61F2/82 ,  A61F2310/00389 ,  A61L2420/02 ,  B05B13/0221 ,  B05B13/0228 ,  B05B13/041 ,  B05B16/20 ,  B05B16/60 ,  B05B16/90 ,  B05D1/002 ,  B05D1/02 ,  B05D3/0413 ,  B05D3/0493 ,  B05D7/584

摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.

摘要翻译： 一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。 两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。 随着另一组移出并进入干燥区域，一组移入喷雾区域。 此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。 交替过程可以重复任意次数。 喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

公开(公告)号：US06383206B1

公开(公告)日：2002-05-07

申请号：US09475599

申请日：1999-12-30

申请人： Matthew J. Gillick ,  Scott J. Huter ,  Kent C. B. Stalker ,  Benjamin C. Huter ,  Anuja Patel

发明人： Matthew J. Gillick ,  Scott J. Huter ,  Kent C. B. Stalker ,  Benjamin C. Huter ,  Anuja Patel

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2230/0093

摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The system includes filtering elements which are capable of occluding a blood vessel distal to an interventional procedure site, while enabling the blood to flow past the occlusion and filtering the blood to capture embolic material which may be released into the blood during a therapeutic interventional procedure. The filtering elements include an expandable member which is capable of being expanded distal to the area of treatment at the interventional procedure site for occluding the blood vessel and for enabling the blood to pass therethrough while preventing emboli from passing therethrough. The system also includes a sheath movable distally and proximally to enable the filtering elements to expand into position distal to the interventional procedure site for capturing embolic material and to collapse the filtering elements to retain the captured embolic material therein.

摘要翻译： 当在狭窄或闭塞区域进行介入手术以捕获在手术期间可能产生和释放到血流中的任何栓塞物质时，在血管中使用的系统。 该系统包括能够封闭介入手术部位远端的血管的过滤元件，同时使血液能够流过闭塞并过滤血液以捕获在治疗介入手术过程中可释放到血液中的栓塞物质。 过滤元件包括可扩张构件，该可膨胀构件能够在介入手术部位处远离扩张区域扩张，用于阻塞血管并使血液能够通过，同时防止栓塞通过。 该系统还包括可向远侧和近侧移动的护套，以使得过滤元件能够扩展到介入手术部位的远端位置，用于捕获栓塞材料并使过滤元件折叠以将捕获的栓塞材料保持在其中。

公开(公告)号：US08567340B2

公开(公告)日：2013-10-29

申请号：US12540302

申请日：2009-08-12

申请人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

发明人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

IPC分类号： B05C5/02

CPC分类号： F26B9/06 ,  A61F2/82 ,  A61F2310/00389 ,  A61L2420/02 ,  B05B13/0221 ,  B05B13/0228 ,  B05B13/041 ,  B05B16/20 ,  B05B16/60 ,  B05B16/90 ,  B05D1/002 ,  B05D1/02 ,  B05D3/0413 ,  B05D3/0493 ,  B05D7/584

摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.

摘要翻译： 一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。 两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。 随着另一组移出并进入干燥区域，一组移入喷雾区域。 此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。 交替过程可以重复任意次数。 喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

公开(公告)号：US06755854B2

公开(公告)日：2004-06-29

申请号：US09919491

申请日：2001-07-31

申请人： Matthew J. Gillick ,  Kent C. B. Stalker

发明人： Matthew J. Gillick ,  Kent C. B. Stalker

IPC分类号： A61F206

CPC分类号： A61F2/95 ,  A61F2002/9517 ,  A61M2025/0681

摘要： A control device and mechanism for deploying a self-expanding medical device includes an actuating mechanism which allows the user to retract a restraining sheath from the self-expanding medical device by using a motion that is in angle to the line of motion of the restraining sheath, which helps prevent movement of the catheter portion of the control device within the patient. The control mechanism allows the physician to obtain a longer retracting stroke to the restraining sheath with a shorter actuating motion reducing the amount of manual actuation needed to be performed by the physician when retracting the sheath. The control mechanism can also reduce the amount of actuating force needed to retract the restraining sheath by utilizing springs or biasing members in connection with the actuating mechanism which combines with the actuating force supplied by the physician to cause the retraction of the restraining sheath.

摘要翻译： 用于展开自扩张医疗装置的控制装置和机构包括致动机构，该致动机构允许使用者通过使用与限制鞘的运动线成一定角度的运动从自扩张医疗装置缩回约束护套 ，其有助于防止控制装置在患者体内的导管部分的移动。 控制机构允许医师以较短的致动运动获得对约束护套的更长的缩回行程，从而减少当缩回护套时医师执行的手动致动量。 控制机构还可以通过利用与致动机构相结合的弹簧或偏压构件来减少约束护套缩回所需的致动力的量，该致动机构与由医师提供的致动力结合以引起约束护套的缩回。

公开(公告)号：US06702834B1

公开(公告)日：2004-03-09

申请号：US09727102

申请日：2000-11-28

申请人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

发明人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US08442656B2

公开(公告)日：2013-05-14

申请号：US11422014

申请日：2006-06-02

申请人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

发明人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573 ,  A61N2001/0585

摘要： A cardiac lead adapted for fixation at least partially within a cardiac vessel. The lead includes, in one embodiment, an elongate lead body defining a proximal region and a distal region including a distal end region having at least one electrode and a distal tip. The distal end region is configured such that the electrode and the distal tip can be implanted in the cardiac vessel. Stiffening structures in the distal region of the lead are adapted to stiffen selected portions of the lead for fixation of the electrode within the cardiac vessel. In some embodiments, the stiffening structures include an implantable member adapted to be implanted in a lumen of the lead. In other embodiments, the stiffening structures include a sheath adapted to be deployed over the lead body. In still other embodiments, the stiffening structures are integral to the lead and/or the lead body.

摘要翻译： 适于至少部分地固定在心脏血管内的心脏引线。 在一个实施例中，引线包括限定近端区域的细长引线体和包括具有至少一个电极和远端尖端的远端区域的远侧区域。 远端区域被构造成使得电极和远端尖端可以植入心脏血管。 铅的远端区域中的加强结构适于加强导线的选定部分，以将电极固定在心脏血管内。 在一些实施例中，加强结构包括适于植入在引导管腔中的可植入部件。 在其他实施例中，加强结构包括适于部署在引线主体上的护套。 在其他实施例中，加强结构与引线和/或引线主体成一体。

公开(公告)号：US20070282413A1

公开(公告)日：2007-12-06

申请号：US11422012

申请日：2006-06-02

申请人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D' aquanni ,  Paul E. Zarembo

发明人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D' aquanni ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N2001/0585

摘要： A cardiac lead adapted for fixation at least partially within a cardiac vessel. The lead includes, in one embodiment, an elongate lead body defining a proximal region and a distal region including a distal end region having at least one electrode and a distal tip. The distal end region is configured such that the electrode and the distal tip can be implanted in the cardiac vessel. Stiffening structures in the distal region of the lead are adapted to stiffen selected portions of the lead for fixation of the electrode within the cardiac vessel. In some embodiments, the stiffening structures include an implantable member adapted to be implanted in a lumen of the lead. In other embodiments, the stiffening structures include a sheath adapted to be deployed over the lead body. In still other embodiments, the stiffening structures are integral to the lead and/or the lead body.

摘要翻译： 适于至少部分地固定在心脏血管内的心脏引线。 在一个实施例中，引线包括限定近端区域的细长引线体和包括具有至少一个电极和远端尖端的远端区域的远侧区域。 远端区域被构造成使得电极和远端尖端可以植入心脏血管。 铅的远端区域中的加强结构适于加强导线的选定部分，以将电极固定在心脏血管内。 在一些实施例中，加强结构包括适于植入在引导管腔中的可植入部件。 在其他实施例中，加强结构包括适于部署在引线主体上的护套。 在其他实施例中，加强结构与引线和/或引线主体成一体。

公开(公告)号：US07252675B2

公开(公告)日：2007-08-07

申请号：US10260710

申请日：2002-09-30

申请人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

发明人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

摘要翻译： 用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架 第二控制臂通过部分回路。 部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。 可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。 此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。 此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

公开(公告)号：US06652576B1

公开(公告)日：2003-11-25

申请号：US09590307

申请日：2000-06-07

申请人： Kent C. B. Stalker

发明人： Kent C. B. Stalker

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0018

摘要： A stent having a structure differentiated in terms of its stiffness. Such differentiation is achieved with the use of a superelastic material that transitions between a relatively soft and malleable phase to a stiffer phase at a transition temperature that is adjustable. By differentially adjusting the transition temperature of different portions of the stent, a differentiation of the stiffness of the structure is achieved upon the stent being subjected to body temperature.

摘要翻译： 具有在其刚度方面不同的结构的支架。 这种分化是通过使用在可调节的转变温度下在相对柔软和可延展的相之间转变成更硬相的超弹性材料来实现的。 通过差异调节支架的不同部分的转变温度，在支架经受体温后实现结构刚度的分化。