公开(公告)号：US08253098B2

公开(公告)日：2012-08-28

申请号：US13001330

申请日：2009-06-04

申请人： Kenzo Hiraoka ,  Lee Chuin Chen

发明人： Kenzo Hiraoka ,  Lee Chuin Chen

IPC分类号： H01J49/10

CPC分类号： H01J49/142 ,  H01J49/165 ,  H05H1/2406 ,  H05H2001/2443

摘要： An ionization apparatus comprises a first electrode provided on the outer periphery of a dielectric cylindrical body and a second cylindrical electrode placed inside at a center of the cylindrical body. When an AC high voltage is impressed across the first electrode and the second cylindrical electrode, a barrier discharge occurs within the cylindrical body. A distal end portion of the second cylindrical electrode projects outwardly from the distal end of the cylindrical body, a thermal equilibrium plasma P having a low electron temperature is generated outwardly from the distal end of the cylindrical body without a plasma jet ascribable to the barrier discharge emerging outwardly from the distal end of the cylindrical body. By exposing a sample S to the thermal equilibrium plasma P, particles (atoms, molecules) desorbed from the sample S undergo soft ionization without being decomposed or polymerized.

摘要翻译： 电离装置包括设置在电介质圆柱体的外周上的第一电极和位于圆柱体的中心的第二圆柱形电极。 当跨越第一电极和第二圆柱形电极施加AC高电压时，在圆柱体内发生阻挡放电。 第二圆柱形电极的远端部分从圆柱形主体的远端向外突出，具有低电子温度的热平衡等离子体P从圆筒体的远端向外产生，而不产生等离子体射流，其属于阻挡放电 从圆柱体的远端向外露出。 通过将样品S暴露于热平衡等离子体P，从样品S解吸的颗粒（原子，分子）经历软电离而不分解或聚合。

公开(公告)号：US20080054176A1

公开(公告)日：2008-03-06

申请号：US10594837

申请日：2004-03-30

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： H01J49/10

CPC分类号： H01J49/164

摘要： A laser spray method exhibiting a high detection sensitivity when applied to mass analysis has its sensitivity raised further. In a laser spray method of ionizing a liquid sample by irradiating, with a laser beam, the end of a capillary into which the sample has been introduced, use is made of an infrared laser as the laser beam, at least the end of the capillary is formed of a substance that does not readily absorb the laser beam used, and either the capillary is formed of a conductor and a high voltage is applied thereto, or the capillary is formed of an insulator, a conductive wire is placed inside a small cavity of the capillary and a high voltage is applied to the conductive wire.

摘要翻译： 当应用于质量分析时表现出高检测灵敏度的激光喷射方法具有进一步的灵敏度。 在通过用激光束照射样品已经被引入的毛细管的端部的电离液体样品的激光喷射方法中，使用作为激光束的红外激光器，至少毛细管的末端 由不容易吸收所使用的激光束的物质形成，并且毛细管由导体形成，并且施加高电压，或者毛细管由绝缘体形成，导线放置在小腔内 并且高电压被施加到导线上。

公开(公告)号：US08871522B2

公开(公告)日：2014-10-28

申请号：US13210166

申请日：2011-08-15

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： G01N33/00 ,  H01J27/02 ,  H01J49/14

CPC分类号： H01J27/028 ,  G01N33/0036 ,  H01J27/026 ,  H01J49/145 ,  Y10T436/206664 ,  Y10T436/24

摘要： The presence of hydrogen peroxide vapor is detected with high sensitivity. Oxygen molecules in the air are ionized by electrons generated by a discharge plasma, thereby producing an oxygen molecule negative ion O2−. The oxygen molecule negative ion O2− produced is supplied to a space in which a hydrogen peroxide molecule H2O2 is to be detected. If a hydrogen peroxide molecule H2O2 is present, a cluster ion O2−(H2O2) of the oxygen molecule negative ion O2− and hydrogen peroxide molecule H2O2 is produced. The hydrogen peroxide molecule H2O2, therefore, can be detected by mass spectrometry. Other gas-phase negative ions such as chloride ion Cl− can be used besides the oxygen molecule negative ion O2−.

摘要翻译： 以高灵敏度检测过氧化氢蒸气的存在。 空气中的氧分子被放电等离子体产生的电子电离，从而产生氧分子负离子O2-。 所产生的氧分子负离子O 2 - 被供给到要检测过氧化氢分子H 2 O 2的空间。 如果存在过氧化氢分子H 2 O 2，则产生氧分子负离子O 2 - 和过氧化氢分子H 2 O 2的簇离子O 2 - （H 2 O 2）。 因此，过氧化氢分子H 2 O 2可以通过质谱法检测。 除了氧分子负离子O2-之外，还可以使用其他气相负离子如氯离子Cl-。

公开(公告)号：US08450682B2

公开(公告)日：2013-05-28

申请号：US13125437

申请日：2009-10-19

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： H01J49/10

CPC分类号： H01J49/0459 ,  H01J49/165

摘要： The tip of an electrically conductive probe 11 is brought into contact with a sample and captures the sample S under atmospheric pressure, a high voltage for electrospray is applied to the probe 11 while a solvent is supplied to the tip of the probe 11 that has captured the sample, and molecules of the sample S at the probe tip are ionized. A miniscule amount of a fine solvent droplet is supplied to the probe tip and slow electrospray is implemented. As a result, the size of the electrically charged droplet can be made extremely small and components within the sample can be analyzed extensively without selectivity. Further, in imaging over an extended period of time, electrospray is possible even in the event that the sample dries.

摘要翻译： 导电探针11的尖端与样品接触并在大气压下捕获样品S，在将溶剂供应到已经捕获的探针11的尖端的情况下，将电喷雾的高电压施加到探针11 探针尖端的样品和样品S的分子被离子化。 将微量的细溶剂液滴供应到探针尖端，并实施慢速电喷雾。 结果，电荷液滴的尺寸可以非常小，并且可以广泛地分析样品中的组分而没有选择性。 此外，在长时间的成像中，即使在样品干燥的情况下也可以进行电喷雾。

公开(公告)号：US20060208741A1

公开(公告)日：2006-09-21

申请号：US10567382

申请日：2004-02-27

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： G01N27/62

CPC分类号： H01J49/142 ,  H01J49/165

摘要： Biological molecules such as protein molecules are ionized without being damaged. Massive cluster ions of a water/methanol mixture (to which acetic acid or ammonia, etc., has been added) (in the vicinity of dry ice—acetone temperature) are generated in a charged-droplet generating chamber 31 by a cold electrospray 32, and the ions are accelerated in an evacuated acceleration chamber 41 by a high-voltage electric field on the order of 10 KV, thereby bombarding a biological sample thin film, which has been applied to a cooled specimen substrate, and achieving ionization of large biomolecules.

摘要翻译： 生物分子如蛋白质分子被电离而不被损坏。 通过冷电喷雾32在带电液滴产生室31中产生水/甲醇混合物（加入了乙酸或氨等）（在干冰 - 丙酮温度附近）的大量离子 ，离子通过10KV的高压电场在真空加速室41中加速，从而轰击已经施加到冷却的样品基板上的生物样品薄膜，并实现大的生物分子的电离 。

公开(公告)号：US07091493B2

公开(公告)日：2006-08-15

申请号：US10843596

申请日：2004-05-12

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： G01N21/01 ,  G01N21/51 ,  G01N23/10 ,  G01N23/12

CPC分类号： H01J49/145

摘要： Ionization efficiency is improved in Penning ionization capable of selective ionization. A metastable excited species of a rare gas is produced by introducing the rare gas into an ionization space and inducing an electrical discharge, a sample gas is introduced into the ionization space and Penning ionization is produced owing to collision between the sample gas and the metastable excited species of the rare gas. Electrons released from atoms or molecules positively ionized by Penning ionization are captured by applying a positive potential to an electron-capture electrode placed in the ionization space, and the atoms or molecules positively ionized are guided to a mass analyzer.

摘要翻译： 在能够选择性电离的Penning电离中，电离效率得到改善。 通过将稀有气体引入电离空间并引起放电，产生亚稳态的稀有气体，样品气体被引入电离空间，由于样品气体与亚稳激发态之间的碰撞而产生Penning电离 稀有气体种类。 通过对通过Penning电离正离子化的原子或分子释放的电子通过对放置在电离空间中的电子捕获电极施加正电位而被捕获，并将正离子化的原子或分子引导到质量分析器。

公开(公告)号：US20050001161A1

公开(公告)日：2005-01-06

申请号：US10843596

申请日：2004-05-12

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： G01N27/68 ,  G01N27/62 ,  H01J49/10 ,  H01J49/14 ,  H01J49/26

CPC分类号： H01J49/145

摘要： Ionization efficiency is improved in Penning ionization capable of selective ionization. A metastable excited species of a rare gas is produced by introducing the rare gas into an ionization space and inducing an electrical discharge, a sample gas is introduced into the ionization space and Penning ionization is produced owing to collision between the sample gas and the metastable excited species of the rare gas. Electrons released from atoms or molecules positively ionized by Penning ionization are captured by applying a positive potential to an electron-capture electrode placed in the ionization space, and the atoms or molecules positively ionized are guided to a mass analyzer.

摘要翻译： 在能够选择性电离的Penning电离中，电离效率得到改善。 通过将稀有气体引入电离空间并引起放电，产生亚稳态的稀有气体，样品气体被引入电离空间，由于样品气体与亚稳激发态之间的碰撞而产生Penning电离 稀有气体种类。 通过对通过Penning电离正离子化的原子或分子释放的电子通过对放置在电离空间中的电子捕获电极施加正电位而被捕获，并将正离子化的原子或分子引导到质量分析器。

公开(公告)号：US06472299B2

公开(公告)日：2002-10-29

申请号：US09811785

申请日：2001-03-20

申请人： Kenzo Hiraoka ,  Chiharu Miyata ,  Toshiyuki Takamatsu

发明人： Kenzo Hiraoka ,  Chiharu Miyata ,  Toshiyuki Takamatsu

IPC分类号： H01L2120

CPC分类号： C23C16/452 ,  Y10T117/1016

摘要： A substrate M having a thin film on its surface is supported on a support 4. A gas discharge opening 12A of hydrogen radicals which faces the thin film on the substrate is provided. A semiconductor thin film is deposited on the substrate M by supplying the thin film with hydrogen radicals H from the gas discharge opening 12A while the substrate M is cooled via to 40 K or less through heat conduction via the support 4 by means of refrigerator 3.

摘要翻译： 在其表面上具有薄膜的基板M被支撑在支撑件4上。提供了与基板上的薄膜相对的氢自由基气体排出口12A。 通过借助于冰箱3经由支撑件4通过热传导将衬底M冷却至40K以下，从气体排出口12A向薄膜供给氢原子H，从而将半导体薄膜沉积在衬底M上。

公开(公告)号：US09111739B2

公开(公告)日：2015-08-18

申请号：US13491331

申请日：2012-06-07

申请人： Kenzo Hiraoka

发明人： Kenzo Hiraoka

IPC分类号： H01J49/26 ,  H01J49/16 ,  G01N30/72 ,  G01N1/38

CPC分类号： H01J49/165 ,  G01N1/38 ,  G01N30/7266 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167

摘要： It is arranged so that living tissue that has not been pretreated can be adopted as a sample of interest. A sample is introduced into at least a tip portion of a hollow insulated sample holder 11 having a small hole 11a in the tip portion. A slender metal wire 12, which has been inserted into the sample holder 11 from the rear, is projected outwardly from the sample holder 11 through the hole 11a while being brought into contact with the sample. A high voltage is applied to the slender metal wire 12 at least in a portion of a time period in which the tip of the slender metal wire 12 is being projected outwardly from the hole 11a, thereby ionizing, by electrospray, the sample adhering to the tip of the slender metal wire 12. The ions are introduced into an analyzing apparatus and are analyzed.

摘要翻译： 可以采用未经预处理的活体组织作为感兴趣的样本。 至少在尖端部分具有小孔11a的中空绝缘样品保持器11的尖端部分中引入样品。 已经从后方插入到样品保持器11中的细长金属线12在与样品接触的同时通过孔11a从样品保持器11向外突出。 至少在细长金属线12的前端从孔11a向外突出的时间段的至少一部分时间内对细长的金属线12施加高电压，从而通过电喷雾使附着在 细长金属线12的尖端。将离子引入分析装置并进行分析。

公开(公告)号：US20120292526A1

公开(公告)日：2012-11-22

申请号：US13566463

申请日：2012-08-03

申请人： Kenzo Hiraoka ,  Lee Chuin Chen

发明人： Kenzo Hiraoka ,  Lee Chuin Chen

IPC分类号： H01J27/02

CPC分类号： G01N27/68 ,  H01J49/105 ,  H01J49/145 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/2443

摘要： A sampling nozzle 21, an ion supply tube 31 leading to an analysis apparatus 50 and a barrier discharge tube 11 are connected to first, second and third ends, respectively, of a T-shaped tube 41 having three connecting ports, and the central portion of the T-shaped tube is an ionization chamber SP. The ionization chamber SP is a closed space, and ions generated therein are introduced to the analysis apparatus 50 through the ion supply tube 31. As a result, almost all of the ions are introduced into the interior of the analysis apparatus.

摘要翻译： 通过分析装置50和阻挡放电管11的取样喷嘴21，分离装置50和离子供给管31分别与具有三个连接口的T形管41的第一，第二，第三端连接，中央部 的T形管是电离室SP。 电离室SP是封闭空间，其中产生的离子通过离子供给管31被引入分析装置50.结果，几乎所有的离子被引入到分析装置的内部。