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公开(公告)号：US06979816B2
公开(公告)日：2005-12-27
申请号：US10400356
申请日：2003-03-25
CPC分类号： H01J49/066 , H01J49/107 , H01J49/165
摘要： A method for introducing ions generated in a region of relatively high pressure into a region of relatively low pressure by providing at least two electrospray ion sources, providing at least two capillary inlets configured to direct ions generated by the electrospray sources into and through each of the capillary inlets, providing at least two sets of primary elements having apertures, each set of elements having a receiving end and an emitting end, the primary sets of elements configured to receive a ions from the capillary inlets at the receiving ends, and providing a secondary set of elements having apertures having a receiving end and an emitting end, the secondary set of elements configured to receive said ions from the emitting end of the primary sets of elements and emit said ions from said emitting end of the secondary set of elements. The method may further include the step of providing at least one jet disturber positioned within at least one of the sets of primary elements, providing a voltage, such as a dc voltage, in the jet disturber, thereby adjusting the transmission of ions through at least one of the sets of primary elements.
摘要翻译： 一种通过提供至少两个电喷雾离子源将相对较高压力区域产生的离子引入至少两个电喷雾离子源的方法，提供至少两个毛细管入口，其构造成将由电喷雾源产生的离子引入和穿过每个 毛细管入口，提供具有孔的至少两组主要元件，每组元件具有接收端和发射端，所述主要元件组被配置为在接收端处从毛细管入口接收离子，并且提供次级 具有孔的一组元件具有接收端和发射端，所述次级元件被配置为从所述主要元件组的发射端接收所述离子，并从所述次级元件组的所述发射端发射所述离子。 该方法还可以包括提供位于主要元件组中的至少一个中的至少一个喷射干燥器的步骤，在喷射干燥器中提供诸如直流电压的电压，从而通过至少调节离子的透过率 其中一个主要元素。
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公开(公告)号：US06583408B2
公开(公告)日：2003-06-24
申请号：US09860721
申请日：2001-05-18
申请人： Richard D. Smith , Taeman Kim , Keqi Tang , Harold R. Udseth
发明人： Richard D. Smith , Taeman Kim , Keqi Tang , Harold R. Udseth
IPC分类号： H01J4904
CPC分类号： H01J49/0404 , H01J49/066 , H01J49/165
摘要： A jet disturber used in combination with an ion funnel to focus ions and other charged particles generated at or near atmospheric pressure into a relatively low pressure region, which allows increased conductance of the ions and other charged particles. The jet disturber is positioned within an ion funnel and may be interfaced with a multi-capillary inlet juxtaposed between an ion source and the interior of an instrument maintained at near atmospheric pressure. The invention finds particular advantages when deployed to improve the ion transmission between an electrospray ionization source and the first vacuum stage of a mass spectrometer.
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公开(公告)号：US06787760B2
公开(公告)日：2004-09-07
申请号：US09976505
申请日：2001-10-12
IPC分类号： H01J4900
CPC分类号： H01J49/4215 , H01J49/004
摘要： A method for enhancing the dynamic range of a mass spectrometer by first passing a sample of ions through the mass spectrometer having a quadrupole ion filter, whereupon the intensities of the mass spectrum of the sample are measured. From the mass spectrum, ions within this sample are then identified for subsequent ejection. As further sampling introduces more ions into the mass spectrometer, the appropriate rf voltages are applied to a quadrupole ion filter, thereby selectively ejecting the undesired ions previously identified. In this manner, the desired ions may be collected for longer periods of time in an ion trap, thus allowing better collection and subsequent analysis of the desired ions. The ion trap used for accumulation may be the same ion trap used for mass analysis, in which case the mass analysis is performed directly, or it may be an intermediate trap. In the case where collection is an intermediate trap, the desired ions are accumulated in the intermediate trap, and then transferred to a separate mass analyzer. The present invention finds particular utility where the mass analysis is performed in an ion trap mass spectrometer or a Fourier transform ion cyclotron resonance mass spectrometer.
摘要翻译： 首先使离子样品通过具有四极离子过滤器的质谱仪来提高质谱仪的动态范围的方法，由此测定样品的质谱强度。 从质谱中，然后鉴定该样品内的离子用于随后的喷射。 随着进一步的采样将更多的离子引入质谱仪中，将适当的rf电压施加到四极离子过滤器，从而选择性地排出先前识别的不需要的离子。 以这种方式，期望的离子可以在离子阱中收集较长时间，从而允许更好地收集和随后分析所需的离子。 用于积聚的离子阱可以是用于质量分析的相同的离子阱，在这种情况下，质量分析是直接进行的，或者它可以是中间阱。 在收集是中间阱的情况下，期望的离子积聚在中间阱中，然后转移到单独的质量分析器。 在离子阱质谱仪或傅里叶变换离子回旋共振质谱仪中进行质量分析的本发明具有特殊的用途。
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公开(公告)号：US5073713A
公开(公告)日：1991-12-17
申请号：US530667
申请日：1990-05-29
CPC分类号： H01J49/40 , H01J49/004 , H01J49/32
摘要： Dissociations of multiple-charged ions are detected and analyzed by charge-separation tandem mass spectrometry. Analyte molecules are ionized to form multiple-charged parent ions. A particular charge parent ion state is selected in a first-stage mass spectrometer and its mass-to-charge ratio (M/Z) is detected to determine its mass and charge. The selected parent ions are then dissociated, each into a plurality of fragments including a set of daughter ions each having a mass of at least one molecular weight and a charge of at least one. Sets of daughter ions resulting from the dissociation of one parent ion (sibling ions) vary in number but typically include two to four ions, one or more multiply-charged. A second stage mass spectrometer detects mass-to-charge ratio (m/z) of the daughter ions and a temporal or temporo-spatial relationship among them. This relationship is used to correlate the daughter ions to determine which (m/z) ratios belong to a set of sibling ions. Values of mass and charge of each of the sibling ions are determined simultaneously from their respective (m/z) ratios such that the sibling ion charges are integers and sum to the parent ion charge.
摘要翻译： 通过电荷分离串联质谱法检测和分析多电荷离子的离解。 分析物分子被电离以形成多电荷的母体离子。 在第一级质谱仪中选择特定的电荷亲本离子状态，并检测其质荷比（M / Z）以确定其质量和电荷。 然后将所选择的母体离子解离，每个分离成多个片段，包括一组子离子，每个子离子具有至少一个分子量的质量和至少一个的电荷。 由一个亲本离子（同胞离子）的解离产生的子离子集在数量上变化，但通常包括两个至四个离子，一个或多个多次充电。 第二级质谱仪检测子离子的质荷比（m / z）和它们之间的时间或空间 - 空间关系。 这种关系用于关联子离子以确定哪个（m / z）比属于一组同胞离子。 每个同胞离子的质量和电荷的值由它们各自的（m / z）比同时测定，使得同胞离子电荷是整数，并且与母离子电荷相加。
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5.发明授权公开(公告)号：US06803565B2
公开(公告)日：2004-10-12
申请号：US09860727
申请日：2001-05-18
申请人： Richard D. Smith , Taeman Kim , Harold R. Udseth
发明人： Richard D. Smith , Taeman Kim , Harold R. Udseth
IPC分类号： H01J4904
CPC分类号： H01J49/0404 , H01J49/066 , H01J49/165
摘要： A multi-capillary inlet to focus ions and other charged particles generated at or near atmospheric pressure into a relatively low pressure region, which allows increased conductance of ions and other charged particles. The multi-capillary inlet is juxtaposed between an ion source and the interior of an instrument maintained at near atmospheric pressure, it finds particular advantages when deployed to improve the ion transmission between an electrospray ionization source and the first vacuum stage of a mass spectrometer, and finds its greatest advantages when deployed in conjunction with an electrodynamic (RF) ion funnel deployed within the interior of the mass spectrometer, particularly an ion funnel equipped with a jet disturber.
摘要翻译： 将多个毛细管入口聚焦在大气压下或接近大气压下产生的离子和其他带电粒子到相对较低的压力区域，这样可以增加离子和其他带电粒子的电导率。 多毛细管入口与离子源和维持在接近大气压的仪器的内部并置，当部署以改善电喷雾离子源和质谱仪的第一真空级之间的离子传递时，它具有特别的优点，以及 与部署在质谱仪内部的电动（RF）离子漏斗配合使用时，具有最大的优势，特别是配备有喷射干燥器的离子漏斗。
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公开(公告)号：US5423964A
公开(公告)日：1995-06-13
申请号：US100882
申请日：1993-08-02
IPC分类号： G01N27/447 , G01N30/72 , H01J49/04 , G01N27/26
CPC分类号： H01J49/167 , G01N27/44717 , G01N30/726
摘要： An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.
摘要翻译： 用于分析组合物样品的分子组分的系统和方法的改进，其包括用于与质谱仪和其他检测装置连接的电喷雾离子源的改进。 该改进包括建立独特的电路图案和喷嘴配置，金属涂层和锥形毛细管出口，与毛细管的尺寸相结合以获得最大的灵敏度。
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公开(公告)号：USRE34757E
公开(公告)日：1994-10-18
申请号：US803145
申请日：1991-12-04
IPC分类号： G01N27/447 , H01J49/04 , G01N27/26 , H01J27/02 , H01J49/02
CPC分类号： H01J49/165 , G01N27/4473
摘要： A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., .+-.2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.
摘要翻译： 用于分析组合物样品的分子成分的系统和方法包括：形成样品溶液，通过毛细管电泳将溶液分离成根据其相对电泳迁移率纵向分离的成分的洗脱液，电喷雾洗脱液以形成带电喷雾 其分子成分具有时间分布; 以及根据喷雾中的时间分布来检测或收集分离的成分。 将第一高电压（例如，5-100KVDC）施加到溶液。 通过在毛细管出口处的洗脱液和在出口前方隔开的阴极施加第二高电压（例如，+/- 2-8KVDC）来对喷雾进行充电。 完整的电路由在毛细管出口处直接接触洗脱液的导体或通过围绕毛细管出口以环形护套流动排出的护套电极的导体形成。
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公开(公告)号：US4885076A
公开(公告)日：1989-12-05
申请号：US178046
申请日：1988-04-05
CPC分类号： G01N27/4473 , H01J49/165
摘要： A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., .+-.2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.
摘要翻译： 用于分析组合物样品的分子成分的系统和方法包括：形成样品溶液，通过毛细管电泳将溶液分离成根据其相对电泳迁移率纵向分离的成分的洗脱液，电喷雾洗脱液以形成带电喷雾 其分子成分具有时间分布; 以及根据喷雾中的时间分布来检测或收集分离的成分。 将第一高电压（例如，5-100KVDC）施加到溶液。 通过在毛细管出口处的洗脱液和在出口前方隔开的阴极施加第二高电压（例如，+/- 2-8KVDC）来对喷雾进行充电。 完整的电路由在毛细管出口处直接接触洗脱液的导体或通过围绕毛细管出口以环形护套流动排出的护套电极的导体形成。
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